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Synthesis of 2-alkyl-3-vinyloxaziridines as potential antitumor agents (1990)

Said, Samy B. ; Młochowski, Jacek ; Skarżewski, Jacek

Weinheim : Wiley-Blackwell

Liebigs Annalen 1990 (1990), S. 461-464

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ISSN: 0170-2041

Keywords: Antitumor agents ; Oxaziridines ; Aldimines, unsaturated ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: A convenient method for the synthesis of previously unknown oxaziridines having unsaturated substituents at the 3-position (3a-k) is based on the selective oxidation of the imino group of α,β-unsaturated aldimines 2 with m-chloroperbenzoic acid. The title compounds and 2-tert-butyl-3-(phenylethynyl)oxaziridine (3k) exhibit potent activity against experimental tumor cells in vitro.

Additional Material: 4 Tab.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/jlac.199019900187

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