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  • 1
    Electronic Resource
    Electronic Resource
    CD56-positive (nasal-type T/NK cell) lymphoma arising on the skin (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 24 (1997), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Several authors have reported cases of patients with malignant lymphoma with unique characteristics, designated nasal-type T/NK cell lymphoma, which expresses the natural killer (NK) cell marker and shows frequent extra-nodal involvement and poor prognosis. We report 2 cases of this type of lymphoma which were CD56-positive and showed a histopathologically angiocentric pattern with cutaneous and subcutaneous tumorous lesions. Patient 1 had extensive invasion of skin, underlying skeletal muscle, spleen and bone marrow, and died of sepsis 34 months after onset. Patient 2 had multiple subcutaneous nodules and invasion to mammary gland, lung, lymph node and spleen at the time of her first visit. She died of a rapid invasion of lymphoma cells to the liver 5 months after onset. Both patients showed similar immunophenotypes of tumor cells (CD2+, CD3−, CD4−, CD8−, CD20−, CD56+) and germ line configuration of the heavy chain of immunoglobulin (JH), T-cell receptor C beta-1 subunit DNA and T-cell receptor J gamma subunit DNA. Epstein-Barr virus early regions RNA was demonstrated in the nuclei of tumor cells of both patients with in situ hybridization. The histopathological examination of the skin lesions of both patients revealed the features of angiocentric lymphoma. The detection of CD56 in the tumor cells of cutaneous lymphomas should be routinely performed for the early diagnosis of this type of lymphoma with extremely poor prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1997.tb01320.x
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  • 2
    Electronic Resource
    Electronic Resource
    Five-year survivor with liver metastasis from gastric cancer successfully treated with systemic chemotherapy (2000)
    Springer
    Gastric cancer 3 (2000), S. 106-109 
    Details
    ISSN: 1436-3305
    Keywords: Key words Five-year survivor ; Gastric cancer ; Alpha feto-protein ; Liver metastasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a patient with liver metastasis from gastric cancer who has achieved a 5-year survival after systemic chemotherapy. The patient was diagnosed with advanced gastric cancer and received a total gastrectomy in August 1991, followed by adjuvant chemotherapy. Liver and lymph node metastases were detected in April 1994, and systemic chemotherapy with a combination of etoposide, doxorubicin, and cisplatin was initiated. Although the liver metastasis completely disappeared, lymph node metastasis at the falciform ligament of the liver and around the portal fissure remained after six courses of this therapy. A second type of chemotherapy, a combination of 5-fluorouracil and methotrexate, was then administered, 12 times, from December 1994 to May 1995, during which time no disease progression was observed. After surgery for the metastatic lymph nodes in August 1995, no progression was observed until December 1998, when a tumor thrombus was detected in the portal vein. Combination chemotherapy of irinotecan and cisplatin was initiated in January 1999. Although tumor regression was achieved after two courses of this, the disease continued to progress after five courses. In July 1999, a fourth type of chemotherapy, using 1 M tegafur-0.4 M gimestat-1 M otastat potassium (S-1), was initiated, and size reduction of the tumor thrombus was achieved; this therapy has continued to the time of submission of this report.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00011694
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis and property of soluble poly(1,1′-dialkyl-3,3′-ferrocenylenevinylene)s via titanium-induced dicarbonyl-coupling reaction of 1,1′-dialkylferrocene-3,3′-dicarbaldehydes (1995)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 33 (1995), S. 1589-1596 
    Details
    ISSN: 0887-624X
    Keywords: dicarbonyl-coupling reaction ; ferrocene ; soluble poly(1,1′-dialkyl-3,3′-ferro-cenylenevinylene) ; third-order nonlinear optical property ; electrical conductivity ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1,1′-Dialkylferrocene-3,3′-dicarbaldehydes (1a-c) with long alkyl chains such as ethyl, hexyl, and dodecyl groups were prepared in 13-25% yield via three-step reactions. The titanium-induced dicarbonyl-coupling reaction of 1a-c gave poly(1,1′-dialkyl-3,3′-ferrocenylenevi-nylene)s (2a-c) in quantitative yields, which were the molecular weights of 3000-10,000 and highly soluble in chloroform, benzene, and hexane. The electrical conductivity and the third-order nonlinear optical susceptibility for poly(1,1′-dihexyl-3,3′-ferrocenylenevinylene) (2b) were estimated to be 1 × 10-2 S/cm on doping with iodine and 1-4 × 10-12 esu at a wavelength of 1-2.4 μm, respectively. © 1995 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1995.080331005
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