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  • 1
    Electronic Resource
    Electronic Resource
    Alveolar bone destruction in the immunosuppressed rat (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 17 (1982), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The placement of a ligature around the second maxillary molar of the conventional rat caused osteoclastic bone resorption and simultaneously, alveolar bone formation. The number of peripheral mononuclear cells in the blood and lymphoblastic transformation of spleen cells in response to concanavalin A increased. Cyclophosphamide (CY), an immunosuppressive agent, given shortly after placing the ligature suppressed the lymphoid reactions, spleen size, and bone formation and enhanced bone destruction. CY given in higher doses also suppressed the number of PMN cells. Septicemia developed in several of these animals. Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli were isolated from the blood and/or ligature. Antibiotics prevented bone destruction. Without placing a ligature, the high dose of CY did not result in bone loss.These findings suggest that 1) bone destruction of the ligature-treated rat is of bacterial origin, 2) CY suppresses proliferation of osteoblasts but does not seem to interfere with the activity of osteoclasts, and 3) suppression of the host defenses greatly facilitates bone destruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1982.tb01153.x
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  • 2
    Electronic Resource
    Electronic Resource
    Immunofluorescent studies on circulating lymphocytes in oral mucosal diseases (1971)
    Springer
    Archives of dermatological research 241 (1971), S. 15-21 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden Untersuchungen mit der direkten Immunfluorescenzmethode bei Kranken mit rezidivierenden herpetischen, aphthösen und anderen Mundschleimhautkrankheiten mit Antiherpes- und Antiadenoviruskonjugaten durchgeführt. Sowohl bei den Patienten wie bei den Personen mit intakter Mundschleimhaut wurde eine spezifische Fluorescenz beobachtet. Erhöhte Adenopositivität wurde bei Patienten mit rezidivierenden, besonders mit ständig rezidivierenden Aphthen, erhöhte Herpespositivität bei Kranken mit Erythema multiforme beobachtet. Die mögliche pathologische Rolle der virusantigen-haltenden Lymphocyten wurde angenommen.
    Notes: Summary Circulating lymphocytes of patients with recurrent herpetic, aphthous and other oral mucosal diseases, as well as of persons with intact oral mucosa were examined with direct immunofluorescence method using HVH and adenovirus hyperimmune conjugated sera. Some of the circulating lymphocytes showed a specific fluorescence both in patients and in persons with intact oral mucosa. Increased herpes-positivity was observed only in erythema exsudativum multiforme and increased adeno-positivity in patients with recurrent aphthous stomatitis, especially in cases with constantly recurring aphthae. The possible pathologic role of the circulating virus-antigen-carrier lymphocytes is presumed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00604132
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Human lymphocyte transformation with virus antigens (1971)
    Springer
    Annals of hematology 22 (1971), S. 211-215 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Patienten mit rekurrenter Aphthae und an Kontrollpersonen wurden Versuche über Lymphozytentransformation durchgeführt unter Verwendung von hitzebehandelten Herpes-Virus-hominis- und Adenovirusantigenen verschiedener Typen. Von diesen Virusantigenen riefen nur diejenigen von Herpes-Virus hominis und von Adenovirus Typ I blastogene Transformation in höherem Maße in den Lymphozytenkulturen aphthöser Patienten hervor, während die Kulturen der Kontrollpersonen unverändert blieben. Bei einigen Adenovirustypen wurde Plasmazellreaktion beobachtet. In den Lymphozytenkulturen bestimmter Versuchspersonen wurde neben Lymphoblasten die Wahrscheinlichkeit von polynuklearen Riesenzellen in Erwägung gezogen.
    Notes: Summary Lymphocyte transformation tests were carried out in patients with recurrent aphthae and control persons, using heat treated Herpesvirus hominis and adenovirus antigens of different types. From the virus antigens examined, only the Herpesvirus hominis and adenovirus type 1 antigens caused blastogenic transformation in higher rate in the lymphocyte cultures of aphthous patients, than in those of the control persons. Plasma cell reaction was observed with some adenovirus types, and the appearance of polynuclear giant cells was detected besides the lymphoblasts in the lymphocyte cultures of certain individuals examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01633616
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    Paper (German National Licenses)
    Fulltext
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