ISSN:
1573-9171
Keywords:
2-ethoxycarbonyl-5,6,7,8-tetrafluorochromone, 2-carboxy-5,6,7,8-tetrafluorochromone
;
primary and secondary amines, ethylenediamine
;
nucleophilic replacement
;
α,β-unsaturated ketones
;
nucleophilic addition at activated double bond
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The direction of reactions of 2-ethoxycarbonyl-5,6,7,8-tetrafluoro- and 2-carboxy-5,6,7,8-tetrafluorochromones with ammonia, methylamine, hexylamine, and aniline depends on the inductive effect of the substituent at position C-2 of the chromone and on the basicity of the amine. Nucleophilic aromatic substitution of a fluorine atom takes place in the interaction of 2-ethoxycarbonyl-5,6,7,8-tetrafluorochromone with secondary amines (morpholine,N-methylpiperazine) and ethylenediamine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00717353
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