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  • 1
    Electronic Resource
    Electronic Resource
    Parathyroid gland function in secondary hyperparathyroidism (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 359-363 
    Details
    ISSN: 1432-198X
    Keywords: Secondary hyperparathyroidism ; Parathyroid hormone ; 1,25-Dihydroxyvitamin D ; Parathyroid gland function ; Dialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The parathyroid glands play a critical role in the maintenance of calcium homeostasis. It has been suggested that the set-point for calcium-regulated parathyroid hormone (PTH) release is higher in uremic patients than normal subjects. However, these assessments of parathyroid gland function have been performed using methods that differed from the original four-parameter model. Dynamic testing of the parathyroid glands has been performed with standardized infusions of calcium gluconate and sodium citrate in dialysis patients with secondary hyperparathyroidism and in normal volunteers. In addition, similar studies have been carried out before and after 4 months of intermittent calcitriol therapy. The derived values for the set-point were 1.21+0.04 mmol/l and 1.24+0.06 mmol/l, respectively in control and dialyzed patients (NS). Furthermore, the values for set-point were 1.21+0.01 and 1.22+0.01 mmol/l (NS), before and after calcitriol therapy. In addition, when subjects were grouped according to the severity of secondary hyperparathyroidism, the set-point calcium-regulated PTH release did not differ between the groups. Calcitriol therapy alters the secretory capacity of the parathyroid glands during hypocalcemia. The degree of parathyroid enlargement and the type of cell proliferation may be more important determinants of the severity of secondary hyperparathyroidism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866785
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Psychological distress and treatment adherence among children on dialysis (1997)
    Springer
    Pediatric nephrology 11 (1997), S. 604-606 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Dialysis ; Depression ; Adherence ; Compliance ; Psychological well-being ; Continuous ambulatory peritoneal dialysis ; Continuous cycling peritoneal dialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Among 23 pediatric renal dialysis patients, we obtained self-reported assessments of psychological adjustment and biochemical and subjective ratings of adherence. Findings indicate elevated levels of depressive symptoms and substantial nonadherence. Depressive symptoms were associated with higher levels of hopelessness, more negative self-perceptions, and more depressogenic attributional style. The psychological adjustment measures did not significantly correlate with adherence. Nonsignificant associations among different measures of adherence underscore its multifaceted nature. Implications for monitoring the adjustment of children on dialysis, assessing adherence, and future research are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050346
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Experience with continuous cycling peritoneal dialysis during the first year of life (1987)
    Springer
    Pediatric nephrology 1 (1987), S. 172-175 
    Details
    ISSN: 1432-198X
    Keywords: Infancy ; Renal failure ; Dialysis ; Continuous cycling peritoneal dialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical experience in eight infants aged 5.8±2.3 (SD) months at the initiation of continuous cycling peritoneal dialysis (CCPD) is described. BUN, creatinine, albumin, calcium, phosphorus and alkaline phosphatase measurements were performed serially and no changes were seen throughout the follow-up period. Mean total energy and protein intake were 94±8% and 79±9% of the recommended. The initial and final standard deviation scores (SDS) for height were −1.42±1.32 and −2.47±1.36 (P〈0.001), respectively. The SDS for body weight and head circumference were −1.67±0.71 and −1.67±1.04, respectively, at the beginning of the study and −1.83±0.98 and −1.88±1.52, respectively, at the end of the period of observation. The incidence of peritonitis was one episode every 11.6 patient months; six patients developed nine hernias. The present study demonstrates that CCPD is an acceptable dialytic modality, with minimal morbidity, for the management of infants awaiting renal transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00849290
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Acquired cystic kidney disease in children undergoing long-term dialysis (1988)
    Springer
    Pediatric nephrology 2 (1988), S. 8-11 
    Details
    ISSN: 1432-198X
    Keywords: Acquired cystic kidney disease ; Magnetic resonance imaging ; Ultrasonography ; Children ; Peritoneal dialysis ; Hemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acquired cystic kidney disease (ACKD) occurs in adult patients undergoing long-term dialysis. Early detection is important because clinically significant hematuria and malignancies are associated with ACKD. We evaluated by magnetic resonance imaging (MRI) and ultrasonography (US) the incidence of ACKD in 15 patients aged 7.3–21.6 years (mean 15.9 years) with non-cystic primary renal disease. Nine patients had been treated with peritoneal dialysis only, and 6 with both hemodialysis and peritoneal dialysis for 24–73 months (mean 37 months). Three patients (20%) had no cysts. In 5 patients (33%) with bilateral multiple cysts, the diagnosis of ACKD was made by MRI and US. In another 5 patients, solitary cysts were localized to one kidney by MRI, and in 2 patients solitary cysts were seen in both kidneys. This study documents that ACKD is not limited to older patients with end-stage renal disease. Early detection of these cysts can be accomplished by MRI and is warranted since 1 patient developed neoplastic tubular changes which can precede tumor formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870371
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Improved cadaveric renal transplant outcome in children (1991)
    Springer
    Pediatric nephrology 5 (1991), S. 137-142 
    Details
    ISSN: 1432-198X
    Keywords: Renal transplantation ; Sequential immunosuppression ; Graft survival ; Immunosuppression ; Cyclosporine ; Medication noncompliance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We analyzed the results of 165 pediatric cadaver renal transplants performed at the University of California at Los Angeles to identify the factors which are linked to improved allograft survival. Both univariate life-table analysis and the Cox proportional hazard model were used. The use of a sequential immunosuppressive regimen (P〈0.001) and kidneys from of more than 6 years of age (P〈0.001) were found to be the factors having the most influence on primary graft survival. The sequential regimen was the only factor favorably influencing retransplants. With sequential therapy 1- and 2-year actuarial graft survival rates were 94% and 91% in primary transplants, and 82% and 70% in retransplants. Medication noncompliance exerted a large negative effect on transplant outcome. Of 70 recipients who had been on cyclosporine for at least 6 months, 50% evidenced noncompliance. Sixty-four percent of adolescents were noncompliant. Thirteen percent of the recipients lost their graft because of noncompliance. We conclude that good results can be obtained with cadaver renal transplants in children with a sequential immunosuppressive regimen and the use of kidneys from adolescent and adult donors. Noncompliance is a great barrier to long-term success in pediatric transplantation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00852871
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Disodium ethylenediaminetetraacetate: adverse effects in dialyzed children (1993)
    Springer
    Pediatric nephrology 7 (1993), S. 182-184 
    Details
    ISSN: 1432-198X
    Keywords: End-stage renal disease ; Hypocalcemia ; Parathyroid hormone stimulation ; Dialysis ; Sodium citrate ; Ethylenediaminetetraacetate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present report describes untoward effects of disodium ethylenediaminetetraacetate (EDTA) in three of six pediatric patients treated with continuous cycling peritoneal dialysis, in whom this agent was infused intravenously to lower serum ionized calcium levels during dynamic testing of parathyroid gland function. Patients developed an influenza-like syndrome characterized by fever rhinorrhea, cough, sneezing, and lacrimation. All symptoms disappeared within 24 h. A similar degree of hypocalcemia was induced with sodium citrate, an alternative hypocalcemic agent, in the same patients without side effects. Sodium citrate, rather than EDTA, should be used to induce hypocalcemia when assessing parathyroid gland dynamics in children with end-stage renal disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00864391
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    The management of renal osteodystrophy (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 651-653 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Renal osteodystrophy ; Management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004670050183
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Parathyroid gland function in secondary hyperparathyroidism (1996)
    Springer
    Pediatric nephrology 10 (1996), S. 359-363 
    Details
    ISSN: 1432-198X
    Keywords: Key words: Secondary hyperparathyroidism   ;   Parathyroid hormone   ;   1 ; 25-Dihydroxyvitamin D   ;   Parathyroid gland function   ;   Dialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The parathyroid glands play a critical role in the maintenance of calcium homeostasis. It has been suggested that the set-point for calcium-regulated parathyroid hormone (PTH) release is higher in uremic patients than normal subjects. However, these assessments of parathyroid gland function have been performed using methods that differed from the original four-parameter model. Dynamic testing of the parathyroid glands has been performed with standardized infusions of calcium gluconate and sodium citrate in dialysis patients with secondary hyperparathyroidism and in normal volunteers. In addition, similar studies have been carried out before and after 4 months of intermittent calcitriol therapy. The derived values for the set-point were 1.21 + 0.04 mmol/l and 1.24 + 0.06 mmol/l, respectively in control and dialyzed patients (NS). Furthermore, the values for set-point were 1.21 + 0.01 and 1.22 + 0.01 mmol/l (NS), before and after calcitriol therapy. In addition, when subjects were grouped according to the severity of secondary hyperparathyroidism, the set-point calcium-regulated PTH release did not differ between the groups. Calcitriol therapy alters the secretory capacity of the parathyroid glands during hypocalcemia. The degree of parathyroid enlargement and the type of cell proliferation may be more important determinants of the severity of secondary hyperparathyroidism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00866785
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Alport's syndrome and achalasia (1988)
    Springer
    Pediatric nephrology 2 (1988), S. 312-314 
    Details
    ISSN: 1432-198X
    Keywords: Alport's syndrome ; Hereditary nephritis ; Achalasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 7-year-old boy presented with a history of postprandial vomiting, failure to thrive, hematuria, proteinuria and decreased renal function. Electron microscopy of a renal biopsy specimen demonstrated the typical glomerular basement membrane changes associated with Alport's syndrome. Audiometry revealed a moderate bilateral high-tone sensorineural hearing loss. Bilateral anterior lenticonus and a unilateral cataract were also diagnosed. Achalasia diagnosed radiologically and confirmed by biopsy was corrected by surgery. Evaluations of the parents and three siblings were negative. The patient subsequently developed end-stage renal failure. This case report and a review of the literature suggest that achalasia may be part of Alport's syndrome in some patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00858684
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Treatment of severe hypercalcemia with peritoneal dialysis in an infant with end-stage renal disease (1988)
    Springer
    Pediatric nephrology 2 (1988), S. 323-325 
    Details
    ISSN: 1432-198X
    Keywords: Hypercalcemia ; Calcitriol ; Calcium carbonate ; Peritoneal dialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recurrent and unusually severe hypercalcemia was observed in an infant undergoing continuous cyling peritoneal dialysis and receiving oral calcitriol and calcium carbonate. Rapid correction was achieved with peritoneal dialysis using a calcium-free dialysis solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00858688
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    Paper (German National Licenses)
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