ISSN:
1573-7217
Keywords:
breast cancer
;
cell proliferation
;
core needle biopsy
;
ploidy
;
thymidine labeling index
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The evaluability and reliability of proliferative activity (expressed as3H-thymidine labeling index,3H-TdR LI) and ploidy determinations on core needle biopsies were compared with those obtained on surgical material from the same breast cancers. The evaluability of3H-TdR LI on core needle biopsies was markedly lower than that on surgical material (53% vs 100%), and the association between3H-TdR LI values in the 16 cases with both evaluable determinations was poor (rs=0.45). Conversely, determinations of ploidy on core needle biopsy and surgical material provided superimposable results, in terms of evaluability (91% vs 100%) and reliability (rs=0.99). Further efforts are needed to improve sampling procedures for a reliable assessment of biological markers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01975202
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