ISSN:
1432-1335
Keywords:
Creatine kinase BB
;
Breast cancer
;
Estrogens
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The brain-type (BB) isoenzyme of creatine kinase (CK) has recently been shown to be estrogenregulated in human breast cancer cells in vitro. In this study we have correlated the presence of CK-BB, evaluated by immunoperoxidase procedures, with the estrogen receptor (ER) content in 35 primary breast cancers. Of 35 tumors examined, 66% revealed moderate to strong CK-BB immunoreactivity. Staining was exclusively located in the cytoplasm of neoplastic cells. A positive relationship was observed between CK-BB positivity and ER content with ER-rich tumors (〉50 fmoles/mg protein) showing a more intense immunoreactivity than ER-poor ones. The results indicate that CK-BB is estrogen-regulated in human breast cancer and suggest that evaluation of this enzyme may be of potential value for the detection of hormone responsive tumors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00390493
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