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  • 1
    Electronic Resource
    Electronic Resource
    On the aging dynamics in an immune network model (2003)
    Springer
    The European physical journal 34 (2003), S. 119-129 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract. Recently we have used a cellular automata model which describes the dynamics of a multi-connected network to reproduce the refractory behavior and aging effects obtained in immunization experiments performed with mice when subjected to multiple perturbations. In this paper we investigate the similarities between the aging dynamics observed in this multi-connected network and the one observed in glassy systems, by using the usual tools applied to analyze the latter. An interesting feature we show here, is that the model reproduces the biological aspects observed in the experiments during the long transient time it takes to reach the stationary state. Depending on the initial conditions, and without any perturbation, the system may reach one of a family of long-period attractors. The perturbations may drive the system from its natural attractor to other attractors of the same family. We discuss the different roles played by the small random perturbations ("noise") and by the large periodic perturbations ("immunizations").
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1140/epjb/e2003-00203-7
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of scorpion toxin (tityustoxin, TsTx) on the salivary gland of the rat, in vivo and in vitro (1978)
    Springer
    Inflammation research 8 (1978), S. 119-124 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intravenous injection of purified scorpion toxin (tityustoxin, TsTX) brings about the appearance of salivary flow and of kallikrein and amylase secretion in the saliva of rats. In experiments performed in vitro, using slices of parotid gland, a dose-response curve correlating tityustoxin concentration with kallikrein and amylase activities was obtained. The secretion of kallikrein is slower and smaller than that of amylase after up to 60 min of incubation. Experiments in which propranolol, phenoxybenzamine or atropine were injected into rats or added to parotid gland slices showed that the release of kallikrein is more dependent on cholinergic mechanisms, whereas the release of amylase is mainly related to adrenergic effects. Pre-treatment of the animals with reserpine confirms these results. The actions of tityustoxin on the kallikrein and amylase secretions, per min, are more effective than those by pilocarpine and isoproterenol, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972413
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Differential distribution of a second type of tyrosine hydroxylase immunoreactive amacrine cell in the chick retina (1998)
    Springer
    Journal of neurocytology 27 (1998), S. 33-43 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A second population of tyrosine hydroxylase-immunoreactive amacrine cells was demonstrated in embryonic and adult chicken retinas by immunohistochemistry techniques in whole flat-mount preparations. The populations were differentiated on a basis of different immunostaining intensities, levels of stratification in the inner plexiform layer, and topographical distributions. Cells of one type were similar to the previously described dopaminergic amacrine cells, denoted here as tyrosine hydroxylase type 1 cells. Immunoreactive neurons of the second type observed in the present work had relatively smaller somata size, and weaker immunostaining than type 1 cells, and were located preferentially in the ventral retina. These tyrosine hydroxylase type 2 cells could be visualized from embryonic day 14 to 21 days after hatching animals. The distribution of the second population was coincident with that of the targets of centrifugal fibres and with cells involved in long proprioretinal connections. We propose that the tyrosine hydroxylase type 2 amacrine cells found in the ventral retina could mediate an important pathway to the upper half of the visual field so as to aid in the detection of predators.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006934919616
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    Paper (German National Licenses)
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