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  • 1
    Electronic Resource
    Electronic Resource
    Is lithium able to reverse neurological damage induced by vinca alkaloids? (1999)
    Springer
    Journal of neural transmission 106 (1999), S. 569-575 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: Chemotherapy ; lithium ; neurotoxicity ; vinca alkaloids.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. Lithium (Li) actively antagonises the inhibiting action of vinca alkaloids on human leukocyte chemotaxis; it proved to be related to the activation of microtubular system, possibly mediated by its inhibiting effect on cyclic AMP. Vinca alkaloids induce peripheral neuropathy and muscle damage. The molecular basis of this neurotoxicity has not been fully explained, but a possible role of neurofibrillary degeneration has been reported. We studied both in animals and in humans, whether Li is able to antagonise vinca alkaloid neurotoxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050180
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  • 2
    Electronic Resource
    Electronic Resource
    Plaque surface and microembolic signals in moderate carotid stenosis (1999)
    Springer
    Italian journal of neurological sciences 20 (1999), S. 179-182 
    Details
    ISSN: 1126-5442
    Keywords: Key words Angiography ; Carotid plaque ; Microembolism ; Transcramial Doppler
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed Transcranial Doppler Monitoring to detect microembolic signals (MES) in 47 patients with moderate (30%–69%) carotid stenosis proven by selective angiography. We compared the occurence of MES with the clinical characteristics of stenosis (symptomatic or asymtpomatic) and the angiographic plaque features (nonulcerated, deep ulceration, superficial ulceration, ulceration with flap, or ulceration without flap). For these cases there was no indication for endarterectomy, nevertheless we thought it would be useful to identify risk subgroups that might benefit from surgical treatment. MES were detected in 17.9% of the stenoses with a prevalence (p 〈 .01) in symptomatic cases (25%) compared to asymptomatic cases (14.3%). There was a significant correlation of MES with plaque ulceration (p 〈 .01) and particularly with ulceration without flap (p 〈 .01). No difference between deep and superficial ulceration was observed. The availability of prospective data on this topic might be useful to select subgroups of patients with moderate carotid stenosis at risk for embolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100720050029
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  • 3
    Electronic Resource
    Electronic Resource
    R1 responses of the trigeminofacial reflex in lesions extrinsic to the brain stem (1984)
    Springer
    Neurological sciences 5 (1984), S. 41-44 
    Details
    ISSN: 1590-3478
    Keywords: Trigeminofacial reflex ; early response ; lesions extrinsic to the brain stem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Una compromissione isolata o prevalente delle risposte R 1 del riflesso trigemino facciale (rtf) è stata descritta sia nelle lesioni intrinseche del tronco dell'encefalo, che nelle estrinseche. Una giustificazione a tale reperto, in corso di lesioni estrinseche, non è tuttavia riportata in letteratura. Vengono qui riferiti i dati relativi ad una serie di soggetti con lesioni estrinseche del tronco encefalico, associate a compromissione esclusiva o prevalente di R 1.Tale reperto può essere giustificato alla luce della particolare situazione anatomica delle varie fibre nervose sensitive componenti la radice del trigemino.
    Notes: Abstract Isolated or prevalent impairment of the trigeminofacial reflex (tfr) has been described both in pontine lesions and in lesions extrinsic to the brain stem. No satisfactory explanation of this finding in extrinsic lesions has ever been put forward. In a series of patients with lesions outside the brain stem together with selective or prevalent R 1 impairment reported here this finding can be explained by the peculiar anatomy of the various nerve fibers in the trigeminal sensory root.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02043968
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  • 4
    Electronic Resource
    Electronic Resource
    Multimodality evoked potentials in myotonic dystrophy (1989)
    Springer
    Neurological sciences 10 (1989), S. 61-67 
    Details
    ISSN: 1590-3478
    Keywords: Myotonic dystrophy ; evoked potentials ; central nervous system involvement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario I potenziali evocati multimodali sono stati effettuati in 18 pazienti (8 maschi e 10 femmine), affetti da distrofia miotonica. Lo scopo era di effettuare una valutazione elettrofisiologica dell'interessamento del sistema nervoso centrale in questa malattia. I potenziali evocati del tronco, somatosensitivi e visivi sono risultati abnormi rispettivamente nel 53%, 62.5% e 71.4% dei casi, senza apparente relazione con la gravità della malattia. I risultati da noi ottenuti forniscono un'ulteriore conferma dell'interessamento del SNC nella distrofia miotonica che è possibile in varie combinazioni, suggerendo un aspecifico interessamento a diversi livelli, che riflette il carattere multisistemico della malattia.
    Notes: Abstract Multimodality evoked potentials were performed in 18 patients affected by myotonic dystrophy (8 males and 10 females); the aim was to make an electrophysiological evaluation of the central nervous system involvement in this disease. We observed brainstem, somatosensory and visual evoked potential abnormalities respectively in 53%, 62.5% and 71.4% of cases, with no apparent relationship to the severity of the disease. Our abnormal findings provide further confirmation of CNS involvement in myotonic dystrophy and occur in various combinations suggesting an aspecific involvement at different levels, reflecting the multisystemic character of this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02333873
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  • 5
    Electronic Resource
    Electronic Resource
    Repetitive nerve stimulation in the differential diagnosis of congenital myotonia (1984)
    Springer
    Neurological sciences 5 (1984), S. 385-390 
    Details
    ISSN: 1590-3478
    Keywords: Dominant congenital myotonia ; recessive congenital myotonia ; repetitive nerve stimulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Sono stati studiati 9 pazienti affetti da miotonia congenita, tre con forma dominante e 6 con forma recessiva, mediante stimolazione ripetitiva a 5 Hz del nervo ulnare. A tale frequenza di stimolo il comportamento della risposta motoria appare differenziarsi nettamente tra le due forme. Tutti i pazienti con forma recessiva, contrariamente alle forme dominanti, mostrano un netto decremento alla stimolazione ripetitiva. L'entità ed il decorso di tale decremento appaiono quantitativamente legati alla paresi muscolare. Nella serie è compreso un caso con miotonia congenita dominante di tipo II [4], il cut comportamento alla stimolazione ripetitiva non differisce rispetto agli altri casi con forma classica di Thomsen. Tale metodica elettrofisiologica pertanto sembra un sicuro mezzo per la diagnosi differenziale nei casi sporadici tra forme recessive e dominanti di miotonia congenita.
    Notes: Abstract Repetitive stimulation of the ulnar nerve at 5 Hz was performed in 9 patients with congenital myotonia, 3 with dominant and 6 with recessive transmission. At this frequency the motor response differed markedly, all the patients with the recessive form presenting a clear decremental response to repeated stimulation. The size and time course of the decrease seem to be related to the degree of muscular paresis. The series includes one case of dominant congenital myotonia type II, whose response to repetitive stimulation, reported for the first time, did not differ from that of the other cases with the classic Thomsen form. Electromyography would thus seem to be a sure means of differentiating recessive from dominant forms of congenital myotonia in sporadic cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02042621
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  • 6
    Electronic Resource
    Electronic Resource
    Clinical and electrophysiological findings in two cases of Miller Fisher syndrome (1990)
    Springer
    Neurological sciences 11 (1990), S. 387-390 
    Details
    ISSN: 1590-3478
    Keywords: Miller Fisher syndrome ; clinical and electrophysiological findings ; brainstem auditory evoked potentials ; trigeminofacial reflex ; pathogenetic mechanims
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Sono riportati i dati clinici, radiologici ed elettrofisiologici di due pazienti con sindrome di Miller Fisher (SMF), caratterizzata da atassia, oftalmoplegia ed areflessia. Di tutte le indagini eseguite solo quelle elettrofisiologiche trofisiologiche hanno fornito indizi sulla sede anatomica delle lesioni e sulle strutture coinvolte, evidenziando un quadro significativo di alterazioni del troncoencefalo. Gli autori discutono il ruolo delle teorie centrale e periferica alla base di questi dati e sottolineano che le informazioni elettrofisiologiche avvalorano la prima delle due ed indicano la necessità di riconoscere nella SMF una entità clinica distinta.
    Notes: Abstract Clinical, radiological and electrophysiological data in two patients with ‘Miller Fisher syndrome’ (MFS), characterized by ataxia, ophthalmoplegia and areflexia are reported. Of the many tests performed only the electrophysiological findings provided any clue to the site of the lesions and the structure involved, showing a significant pattern of brainstem dysfunction. The authors discuss the role of central and peripheral lesion theory in the light of these data and stress that electrophysiological findings lend considerable weight to the former and support the hypothesis that MFS should be recognize as a distinct clinical entity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02335942
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