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  • 1
    ISSN: 1435-2451
    Keywords: Key words Appendectomy ; Laparoscopy ; Meta-analysis ; Randomized controlled trials
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aim: To compare the effectiveness and safety of laparoscopic and conventional “open” appendectomy in the treatment of acute appendicitis. Methods: Meta-analysis of randomised controlled trials available by May 1998 that compared both techniques. Within each trial and for each outcome an effect size was calculated; the effect sizes were then pooled by a random-effects model. Results: We summarised outcome data of 2877 patients included in 28 trials. Operating time was +16 min (95% confidence interval +12–20 min) longer for laparoscopic appendectomy. Overall complication rates were comparable, but wound infections were definitely reduced after laparoscopy [rate difference –4.2%, (–2.3% to –6.1%)]. Intra-abdominal abscesses, however, occurred slightly more frequently [+0.9%, (–0.4% to +2.3%)]. Hospital stay after laparoscopic appendectomy was 15 h (8–23 h) shorter, and patients returned to full fitness or work 7 days (5–9 days) earlier. Pain intensity on day 1 was slightly less. Heterogeneity was present for some outcome measures due to methodological differences among the primary studies. Conclusion: Laparoscopic appendectomy reduces wound infections and eases postoperative recovery. Nevertheless, the various differences among the primary studies and their partly flawed methodology make it difficult to generalise from these findings.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 384 (1999), S. 423-431 
    ISSN: 1435-2451
    Keywords: Key words Evidence-based medicine ; Surgical research ; Rationing ; Clinical practice guidelines ; Health economics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Introduction: Evidence-based medicine (EBM) has been proposed as a new paradigm of practising medicine. However, an unproductive polarisation between supporters and opponents can make its unbiased assessment difficult. This review gives an overview of the arguments and discusses their surgeon-specific importance. Discussion: As EBM claims a position in the centre of medicine, it borders with other highly debated topics as, for instance, rationing and equity of care, doctor–patient interaction, medical research and education. Most arguments against EBM relate to its role in reducing health expenses by rationing healthcare. We think that the principles of EBM can be applied to make the inevitable process of rationing fair and reproducible. In addition, evidence-based surgery is criticised for interfering with patient individuality and physician autonomy, although this is a misunderstanding. Furthermore, the evidence-basis of EBM, in particular the randomised controlled trial (RCT) and systematic review, has been subject of discussion. Additionally, surgical research has its own inherent difficulties and, ultimately, some clinicians have doubted the practical feasibility of applying EBM at the bedside, because searching and critically appraising the literature is too difficult and time consuming. Conclusions: We believe that most critics consider EBM to be a potentially dangerous tool, because they fear it will be used against themselves. Thus, these conflicts only prove that EBM as a methodology may have a strong impact on solving them. As EBM has already made discernible progress, surgeons should not stand aside from these activities, which are bound to strongly influence healthcare in the next century.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-2451
    Keywords: Key words Gastro-oesophageal reflux disease ; Consensus conference ; Laparoscopic fundoplication ; Evidence-based medicine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The aim of this paper is to demonstrate an example of evidence-based medicine for a clinically relevant and frequent disease – gastro-oesophageal reflux disease – for which an increasing number of laparoscopic operations is performed. A consensus development conference was performed on this topic in 1996. During the following 3-year period, increase of knowledge shown by the number of publications was monitored and the consecutive changes of the consensus as well as its consequences and impact were analysed. The six published randomised clinical trials revealed important information about the technique of the laparoscopic operation focussing on the gastric fundic mobilisation and the modification of the anti-reflux wrap. Five consecutive consensus conferences were performed and published. Citations of the 1996 consensus conference could not be found in the major surgical journals – not even by participants of the conference. The responsibility of societies to run such conferences continues.
    Type of Medium: Electronic Resource
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