ISSN:
1432-0584
Keywords:
Plasma levels
;
Interleukin
;
Neutropenia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Plasma levels of IL-1, IL-6, IL-8, IL1-RA, TNF alpha, and G-CSF were prospectively studied during 23 chemotherapy cycles of 20 patients suffering from acute myelogenous leukemia. Increased plasma levels of IL-6, IL-8, and G-CSF were observed in patients with febrile neutropenia and/or major infection. Plasma levels of IL-6, IL-1, TNF alpha and IL-1-RA measured 1 day before and 1 day after the onset of febrile episodes did not accurately predict the development of major infection. In contrast, IL-8 plasma levels were significantly higher in those patients who subsequently developed major infection. The question whether IL-8 plasma levels identify high risk or low risk patients with sufficient specificity and sensitivity has to be answered in large scale clinical trials.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01910312
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