ISSN:
0170-2041
Keywords:
Aryl-aryl coupling, intramolecular
;
Binaphthyls, non-racemic chiral
;
Biaryls, lactone-bridged
;
Helimerization, activation energy of
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A rational synthesis of the biaryl lactone 3 is described. This bridged biaryl, which gradually helimerizes at room temperature, could be synthesized in a non-racemic form, chemically by atropo-selective ring opening with a chiral O-nucleophile and subsequent ring closure, and chromatographically by HPLC on a chiral phase. For the enantiomerization process (M)-3 ⇄ (P)-3, the activation parameters were determined.
Additional Material:
6 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199419940116
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