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  • 1
    Electronic Resource
    Electronic Resource
    Interfering factors to sensitivity and specificity of bronchial reactivity in children (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 4 (1993), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Bronchial reactivity to carbachol, estimated by the PD65, the provocation dose of inhaled carbachol inducing a 65% increase of baseline respiratory resistance, was measured in 355 asthmatic children (age 8.7 ± 2.6 years) and 149 healthy children (age 11.8 ± 2.3 years). The frequency distribution of PD65 snowed apart from 2 minima at 480 μg and 960 μg 2 significant peaks at 240 μg (p = 0.003) and 1200 μg (p = 0.01) to carbachol. reflecting a hyperreactive class (PD65 〈480 μg), an intermediate class (481 ug 〈 PD65 〈 960 μg) and a normo-reactive class (PD65 〉 961 μg). The intermediate class is characterised by a considerable overlap between “health” and “disease”. However, taking into account the degree of air pollution in which healthy children are living (best related factor to specificity) and the type of initial lung function disorder in asthmatic children, (the MEF50 to be the best related factor for specificiy), weighed specificity and sensitivity improved from 64 to 88%. Evaluating bronchial responsiveness in children, such interfering factors should be strongly considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3038.1993.tb00090.x
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  • 2
    Electronic Resource
    Electronic Resource
    Dopamine-beta-hydroxylase in patients with cystic fibrosis (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 80-83 
    Details
    ISSN: 1432-1076
    Keywords: Cystic fibrosis ; Dopamine-beta-hydroxylase ; Catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The enzymatic activity of plasma dopamine-beta-hydroxylase (DBH) was determined in 92 children/adolescents with cystic fibrosis, in 25 parents (heterozygotes) of these patients and in 68 healthy controls. Statistically significant (P〈0.01) lower DBH levels were found in cystic fibrosis patients (17.9±1.4 μmol/min per 1, SEM) compared to the controls (25.5±2.1 μmol/min per 1). In 37 patients plasma norepinephrine and dopamine levels were compared to the enzymatic activity, no significant correlation between these variables being shown (r=-0.134 for norepinephrine; r=0.159 for dopamine). However, due to the large variability of DBH within the groups and due to the lack of relationship of this enzymatic activity to plasma catecholamines, it is concluded that these differences may neither account for the observed elevation of plasma dopamine in cystic fibrosis patients (0.94–6.73 nmol/l vs. 0.01–0.986 nmol/l for controls) nor for their putative autonomic dysfunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441861
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Short-time response characteristics of salbutamol in infants with broncho-pulmonary diseases (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 339-342 
    Details
    ISSN: 1432-1041
    Keywords: asthma ; respiratory distress syndrome ; wheezy bronchitis ; salbutamol ; beta-agonists ; cystic fibrosis ; infants ; whole-body plethysmography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of salbutamol 0.225 mg/kg given systemically on lung function in infants have been measured by whole-body plethysmography in 60 children with broncho-pulmonary diseases (24 after respiratory distress syndrome, 21 with wheezy bronchitis and 15 with cystic fibrosis). A therapeutic action was demonstrated in 74% of the tests, taking into account changes in end-expiratory resting level (state of inflation) and associated changes in airway resistance. There was a significant decrease in thoracic gas volume as an estimate of pulmonary hyperinflation, which was due to improved alveolar ventilation and to a consequential decrease in end-expiratory resting level. The improvement in airway resistence, as an estimate of airway obstruction, reflects a substantial relaxation of bronchial smooth muscle increasing the diameter of the airways. The extent to which similar results may be achieved by topical administration of nebulised beta agonists remains to be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542433
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Immunthrombocytopenic purpura as a model for pathogenesis and treatment of autoimmunity (1995)
    Springer
    European journal of pediatrics 154 (1995), S. S60 
    Details
    ISSN: 1432-1076
    Keywords: Immune thrombocytopenic purpura ; Auto-antibodies ; Against platelets ; Immunoglobulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In honour of Professor Rossi's 80th birthday we review the development of our understanding of the immune and auto-immune nature of the pathogenesis of immune thrombocytopenic purpura (ITP). The immune aspects have been documented by postviral alterations of the cellular and humoral immune system, by new methods of specific auto-antibody detection against platelet glycoproteins and by the therapeutic effect of administering immunoglobulin concentrate from healthy blood donors. The various possible mechanisms of action of immunoglobulin treatment have led to use of this treatment as an alternative for other immune-related disorders. The treatment of severe chronic ITP in children, however, remains unsatisfactory. With a new international clinical and laboratory study of children and adolescents with early chronic ITP we are continuing the investigation of the pathogenesis and treatment of ITP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02191508
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  • 5
    Electronic Resource
    Electronic Resource
    A new baby-spacer device for aerosolized bronchodilator administration in infants with bronchopulmonary disease (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 57-60 
    Details
    ISSN: 1432-1076
    Keywords: Bronchodilators ; Infants ; Bronchopulmonary disease ; Baby-spacer device ; Babyhaler
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The response of salbutamol (Ventolin, Glaxo), topically administered from a metered dose inhaler (MDI) through a new baby-spacer-device (Babyhaler, Glaxo) was studied in 14 infants (8 wheezy infants, 3 infants with cystic fibrosis and 3 infants after respiratory distress syndrome), age 2.9–18.8 months. Changes in thoracic gas volume (TGV) as an estimate of pulmonary hyperinflation and changes in airway conductance (Gaw) as an estimate of bronchial obstruction were assessed by whole-body plethysmography. After baseline measurements, 1 puff of 100 μg salbutamol was given repeatedly at 5 min intervals until 600 μg have been inhaled and TGV and Gaw were measured after each inhalation at 5, 10, 15, 20, 25 and 30 min. Significant improvement in lung function was achieved in 57.1% of infants after 400 μg and in 92.9% of infants after 600 μg salbutamol. The study shows usefulness of bronchodilator treatment in infants with bronchopulmonary disease by a system with a MDI and baby-spacer-device. However a special dose-time relationship must be respected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02073894
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