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  • 1
    Electronic Resource
    Electronic Resource
    Characterization of the two nonallelic genes encoding mouse preproinsulin (1986)
    Springer
    Journal of molecular evolution 23 (1986), S. 305-312 
    Details
    ISSN: 1432-1432
    Keywords: Mouse insulin genes ; S1 nuclease ; Mung bean nuclease ; Primer extension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have cloned and sequenced the two mouse preproinsulin genes. The deduced amino acid sequences of the mature mouse insulins are identical to the published protein sequences. However, the nucleotide sequence indicates that the mouse I C-peptide has a deletion of two amino acids compared with the mouse II C-peptide. We used an S1 nuclease assay to confirm the presence of the deletion and to measure the ratio of transcripts from gene I to transcripts from gene II. The mouse preproinsulin I gene, like the rat gene I, is missing the second intervening sequence that normally interrupts the C-peptide region in other insulin genes. Comparison of the 5′ flanking sequences of the mouse and rat genes II indicates that they are homologous for at least 1000 base pairs. The preproinsulin I genes also share homology in their 5′ flanking DNAs; however, their homology to the preproinsulin II genes extends for only about 500 base pairs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02100639
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Human renin gene is on chromosome 1 (1984)
    Springer
    Somatic cell and molecular genetics 10 (1984), S. 415-421 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract DNA sequences encoding kidney renin were localized to region p21 → qter of human chromosome 1 by Southern blot analysis of mouse-human somatic cell hybrids with a cloned human renin DNA probe. The renin gene may be a member of a chromosome 1 linkage group which is conserved in mouse and man. Available evidence suggests this gene is present in one copy per haploid genome. Thus those renin-like molecules detected immunologically in tissues other than the kidney (such as brain, placenta, uterus, pituitary, vasculature, and adrenal) may be derived from this single gene. Since renin messenger RNA in human kidney is about 1550 nucleotides long, reported molecular weights in excess of 45,000 for circulating renin represent posttranslational or postsecretory modifications of the polypeptide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535637
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mouse kidney renin gene is on chromosome one (1984)
    Springer
    Somatic cell and molecular genetics 10 (1984), S. 633-637 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The structural gene for mouse kidney renin (Ren-1)was localized to chromosome 1 by Southern blot analysis of mouse-hamster somatic cell hybrids with a cloned mouse submandibular renin cDNA probe. The submandibular renin gene (Ren-2)also lies on chromosome 1; so it may be, in those mouse lines which carry it, a tandem duplication of the kidney-type Ren-1gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535229
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    Paper (German National Licenses)
    Fulltext
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