Electronic Resource
Springer
Fresenius' Zeitschrift für analytische Chemie
324 (1986), S. 368-369
ISSN:
1618-2650
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Conclusions The data presented in this paper together with the findings of Hagmann et al. [4] suggest an important role of metabolites of the lipoxygenase pathway in the pathogenesis of endotoxin shock. Selective inhibition of lipoxygenase by FLM 5011 prevented the development of irreversible shock state nearly completely decreasing the mortality rate to 0.05. p ]Further investigations on the precise mechanism of the action of lipoxygenase metabolites are necessary to evaluate their actual significance in the complex pathogenesis of circulatory shock.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00488001
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