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  • 1
    Electronic Resource
    Electronic Resource
    Vimentin expression in 98 breast cancers with medullary features and its prognostic significance (1993)
    Springer
    Virchows Archiv 422 (1993), S. 475-479 
    Details
    ISSN: 1432-2307
    Keywords: Vimentin ; Medullary carcinoma ; Breast
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The expression of vimentin, as assessed by immunohistochemistry, has been evaluated in 69 medullary carcinomas of the breast: 28 typical medullary carcinomas (TMC), 41 atypical medullary carcinomas (AMC), and 29 invasive ductal carcinomas with subtle medullary features that, however, did not fulfil the strict criteria of TMC or AMC. Immunoreactivity of at least 10% of the component cells was found in 14 of the medullary carcinomas (5 out of 28 TMC, 9 out of 41 AMC whereas only 1 of the invasive ductal carcinomas was vimentinpositive. The patients were followed for 8–13 years. No difference in recurrence-free survival or overall survival could be documented between vimentin-positive and vimentin-negative carcinomas with medullary features. No biological significance could be established for vimentin labelling in these lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606456
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  • 2
    Electronic Resource
    Electronic Resource
    Ewing's sarcoma (1989)
    Springer
    Virchows Archiv 414 (1989), S. 243-251 
    Details
    ISSN: 1432-2307
    Keywords: Ewing's sarcoma ; Histology ; Immunohistochemistry ; Prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Histological and immunohistochemical features of 87 patients with conventionally diagnosed Ewing's sarcoma were studied retrospectively on routinely processed material and evaluated with regard to prognostic significance. 74% were convincingly positive when stained for vimentin, 13% were doubtful, and 13% were negative. A varying degree of positivity for neuron-specific enolase (NSE) was found in 15%; these cases all co-expressed vimentin. A single tumour contained scattered cytokeratin-positive cells. Positivity for the leukocyte common antigen (LCA) could be demonstrated in three cases; these were excluded from the statistical analysis of prognostic factors. Growth pattern, soft tissue invasion, monomorphic or dimorphic cell population, and PAS-, NSE- or vimentin-positivity did not influence survival significantly. However, prognosis was increasingly poor with increasing degree of necrosis: median survival was 28 months for grade I necrosis (〈10%), 16 months for grade II (10–50%), and 11 months for grade III (〉50%),p〈0.0005. A mitosis count of 〈1 per high-powerfield (HPF) was correlated to a median survival of 26 months, ≥ 1 per HPF to 12 months,p〈0.05. The findings indicate some degree of heterogeneity in Ewing's sarcoma which may be related to primitive peripheral neuroectodermal tumours (PNETs), or be a true blastoma. In future trials, diagnostic criteria (including immunohistochemistry) should be clearly defined and materials should be large enough to allow for stratification according to prognostic factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00822028
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Immunohistochemical staining for chondroitin sulphate and keratan sulphate. An evaluation of two monoclonal antibodies (1991)
    Springer
    Histochemistry and cell biology 95 (1991), S. 585-589 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Immunohistochemical staining with commercially available antibodies against chondroitin sulphate (clone CS-56) and keratan sulphate (clone 1/20/5-D-4) was compared with two conventional histochemical methods for the demonstration of glycosaminoglycans, namely Alcian Blue with varying pH and critical electrolyte concentrations, and a modified PAS stain. The antibodies were tested on sections from both frozen and fixed, paraffin embedded human material from umbilical cord, skin, and bronchus. The results showed immunostaining to function equally well on frozen and routine sections, and to be superior to Alcian Blue and PAS with regard to morphological detail. Thus, reactivity with anti-chondroitin sulphate was demonstrated in vessel walls, in small nerves, in the basal membrane zone of the skin, in perichondrium, and in and around chondrocytes. Reactivity with anti-keratan sulphate occurred in chondroid matrix and in perichondrial tissue; however, some cells of the bronchial epithelium and mucous glands also exhibited positivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00266746
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Local recurrences in giant cell tumour of bone (1996)
    Springer
    International orthopaedics 20 (1996), S. 172-176 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Nous avons étudié l’interêt pronostic du classement anatomo-pathologique des tumeurs à cellules géantes (osteoclastomes) et le taux de récidives à long terme, locales et à distance, dans une série consécutive de 31 patients. Le classement anatomo-pathologique n’a eu aucun interêt pronostic. Dix-huit patients furent traités par curetage, alors que 13 patients furent traités par une excision large. Dix patients (56%), tous traités par curetage, récidivèrent localement, alors qu’aucune des tumeurs traitées par excisision large ne récidiva (p 〈0.05). Cinq patients (16%) récidivèrent localement et à distance, généralement au niveau pulmonaire. Chez 3 patients, la récidive se déclara en moyenne 12 ans après le traitement initial. L’excision large avec suivi à vie est nécessaire dans ces rares cas de tumeur osseuse.
    Notes: Summary. We studied the value of histopathological grading in determining the prognosis of giant cell tumour (osteoclastoma) and the rate of local and distant recurrences in a consecutive series of 31 patients. We found that grading had no prognostic value. Eighteen patients were treated by intralesional curettage and 13 by wide excision. Ten patients (56%), who were all treated by curettage, had local recurrences, but none of the tumours with wide excision recurred (p 〈0.05). Five (16%) had local recurrences as well as distant metastases, usually to the lungs. The recurrences developed later than an average of 12 years after primary treatment in 3 patients. Wide excision and life-long follow up should be considered in the management of these tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002640050057
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    Paper (German National Licenses)
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