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  • 1
    Electronic Resource
    Electronic Resource
    Organic aciduria and butyryl CoA dehydrogenase deficiency in BALB/cByJ mice (1989)
    Springer
    Biochemical genetics 27 (1989), S. 47-58 
    Details
    ISSN: 1573-4927
    Keywords: organic aciduria ; BALB/cByJ ; mouse genetics ; butyryl CoA dehydrogenase ; short-chain fatty acid metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A metabolic screening program of inbred strains of mice has detected a marked organic aciduria in the BALB/cByJ strain. Gas chromatographic and mass spectrometric analysis identified large quantities ofn-butyrylglycine plus lesser quantities of ethylmalonic acid. Crosses with the nonexcreting C57BL/6J strain indicate that this condition is inherited as an autosomal recessive trait. Independently from this screening a variant with no detectable enzyme activity of butyryl CoA dehydrogenase (BCD) in liver and kidney of the BALB/cByJ strain but not other BALB/c sublines was discovered. Data from a three-point cross indicated that the null variant maps to the structural locus for the enzyme,Bcd-1, on chromosome 5. The findings indicate that a mutation at or nearBcd-1 in the BALB/cByJ strain resulted in a biochemical abnormality manifest as the BCD deficiency. It is concluded that accumulation of butyryl CoA due to a block in the oxidation of short-chain fatty acids results in an overproduction of organic metabolites leading to the observed organic aciduria. The fact that other BALB/c substrains do not exhibit this abnormality further suggests that this disorder reflects subline divergence within the BALB/c family.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563017
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Animal welfare and colony management in cancer research (1997)
    Springer
    Breast cancer research and treatment 46 (1997), S. 313-331 
    Details
    ISSN: 1573-7217
    Keywords: animal welfare ; laboratory animals ; animal husbandry ; experimental design ; experimental neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The use of animals in cancer research continues to be important for the study of tumor biology, the development and testing of new therapies, and risk assessment. The new knowledge generated from this research contributes to the health and welfare not only of human beings, but also of animals which develop cancer. However, the use of animals for cancer research is a privilege which carries with it scientific, professional, and moral obligations. The three tenets of a sound animal research program include good science, humane care, and regulatory compliance. Recognizing the complex interactions in the tumor-animal model, the investigator needs to address a wide range of issues during experimental design and implementation including animal welfare concerns, complicating factors in colony management, and compliance with laws, regulations, and policies. Therefore, both practical and philosophical considerations enjoin researchers to maintain the highest standards of animal care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005978026638
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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