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  • 1
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Einzelne Leberfunktionsproben wurden bei der heterolog perfundierten Leber, sofort nach orthotoper Transplantation und beim normalen Ganztier (Schwein) verglichen. Das biliäre Transportmaximum für Bromsulphalein in Milligramm/Minute ist bei Perfusion und nach Transplantation auf 20-500/0 des Mittelwertes von Normaltieren vermindert. Die Galaktoseeliminationskapazität in Milligramm/Minute/Kilogramm Körpergewicht des Schweines ist während Perfusion auf 30-500/0 des mittleren Normalwertes reduziert, nach Transplantation liegt sie knapp unterhalb der Norm. Der basale Gallenfluß ist bei allen 3 Situationen vergleichbar. Die frisch transplantierte Leber mit ihren reduzierten Partialfunktionen ist imstande, das Leben des Empfängertiers zu erhalten. Die vergleichbare Funktionseinschränkung bei der perfundierten Leber läßt es möglich erscheinen, daß auch dieses Präparat eine lebenserhaltende Gesamtfunktion hat.
    Notes: Summary Individual liver function tests were compared in heterologously perfused liver, immediately after orthotopic transplantation and in the normal whole animal (pig). The biliary transport maximum for bromosulphalein in mg/min is reduced to 20-50% of the mean values of normal animals in perfusion and after transplantation. The capacity to eliminate galactose in mg/min/kg body weight of the pig is reduced to 30-500/0 of the mean normal value during perfusion. After transplantation it lies just below the normal. Basal bile flow is comparable in all three situations. Freshly transplanted liver with its reduced partial functions is capable of sustaining the life of the recipient animal. The comparable limitation of function of the perfused liver makes it seem possible that this preparation also has a life sustaining total function.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Medical & biological engineering & computing 26 (1988), S. 167-174 
    ISSN: 1741-0444
    Keywords: Counterpulsation ; Intra-aortic balloon pump
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The performance of intra-aortic balloon pumping is assessed on the basis of a mock circulation and a theoretical model of arterial pulse propagation. The parameters investigated include timing of onset and speed of inflation and deflation as well as pumped air volume. The models used do not contain any active peripheral elements with regulatory capabilities and so the simulated heart adjusts its stroke volume mechanically according to the operating conditions. The observed and calculated changes of typical quantities in terms of ‘stroke’ volume, ‘LV’, ‘aortic’ and ‘peripheral’ pressures are to be attributed, therefore, to the influence of the mechanical pump operation without physiological reactions of the circulatory system as a whole. It is found that timing details of the counterpulsation have a minor influence on the overall mechanical pump performance. Accordingly, the influence of physiological reactions of the cardiovascular system to changes in pump operation seems to be far more important than the one caused by the purely mechanical changes themselves. However, rapid inflation and deflation of the balloon may be accompanied by severe opening or closing shocks, respectively.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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