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  • 1
    Electronic Resource
    Electronic Resource
    Zur pharmakologischen Wirkung von Cu-Chlorophyllin (1969)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 264 (1969), S. 245-246 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02431441
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Über die Strukturspezifität permeationsfördernder, capillaraktiver Polykationen (1965)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 252 (1965), S. 94-102 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Basische Peptide sowie synthetische Polykationen erhöhen bei lokaler Injektion die Capillardurchlässigkeit für Serumproteine in Abhängigkeit von der Zahl ihrer basischen Bausteine. 2. Während die Aminosäuren Lysin und Arginin als solche praktisch unwirksam sind, nimmt der Effekt von 2 bis ca. 25 basischen Einheiten progredient zu, um sich bei 〉25 positiv geladenen Bausteinen auf einen etwas unterhalb des Optimums liegenden konstanten Bereich einzustellen. Zwischen 3 und 25 basischen Bausteinen je Molekül war der log der äquieffektiven Dosen dem log der Zahl der basischen Komponenten in grober Näherung umgekehrt proportional. 3. Das hier gefundene Verhalten an Blutcapillaren zeigt auffallende Parallelen zur Aufhebung des molekularen Siebeffektes an CS-Protein-Gelen durch Polykationen. An beiden Objekten ist nicht eine spezifische Struktur (z.B. Aminosäuresequenz), sondern die Zahl der positiven Ladungen je Molekül entscheidend. 4. Die hier dargestellten Beziehungen gelten nur für solche Polykationen und Peptide, die keine nennenswerten Wirkungen auf Gefäßmuskeln haben, also die Capillardurchlässigkeit nicht durch Beeinflussung der Mikrozirkulation verändern können.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00246434
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Isolierung und pharmakologische Beeinflussung von Lysosomen aus Rinderleukocyten (1966)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 253 (1966), S. 43-43 
    Details
    ISSN: 1432-1912
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00259245
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Beeinflussung der Masugi-Nephritis durch Cu-Chlorophyllin (1970)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 266 (1970), S. 223-235 
    Details
    ISSN: 1432-1912
    Keywords: Masugi-Nephritis ; Rat Kidney ; Cu-Chlorophylline ; Lysosomal Protease ; Basement Membrane ; Masugi-Nephritis ; Rattenniere ; Cu-Chlorophyllin ; Lysosomale Proteasen ; Basalmembran
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The lethal effects of nephrotoxic serum in rats are delayed and reduced after the intraperitoneal administration of Cu-chlorophylline. 2. Granular fractions obtained from bovine PMN leucoxytes show proteolytic activity which has two pH optima, one in acid and one in neutral solution. This proteolytic activity has been shown to act on isolated basement membranes of rat kidney in vitro. Cu-chlorophylline inhibits the neutral protease only, whereas lysosomal cathepsins are not affected. 3. The mechanism of the chlorophylline effect on the Masugi-Nephritis is discussed. Our findings suggest that chlorophylline acts rather by inhibition of neutral protease activity of PMN leucocytes than by an effect on the complement system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997284
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Cardiovascular reactions induced by leucocidin fromPseudomonas aeruginosa (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 294 (1976), S. 85-89 
    Details
    ISSN: 1432-1912
    Keywords: Cardiovascular failure ; Leucocidin ; Pseudomonas aeruginosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Leucocidin fromPseudomonas aeruginosa causes cardiovascular failure in rats and mice. The time between i.v. injection and death depends on the dose. After injection of high doses (500 μg/kg) the arterial blood pressure decreases rapidly and cardiac irregularities and AV block occur within about 5 min. In contrast to endotoxin shock no pulmonary hypertension was observed, whereas portal hypertension was seen in our experiments. Injection of lower doses (〈200 μg/kg) caused peripheral vascular damage with lung oedema, vascular disturbances in various tissues, exudation and bleeding. Finally cardiac insufficiency predominated. Dexamethasone delayed the symptoms but did not prevent death in either rats or mice. Heparin was ineffective in this type of shock.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00692788
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Decreased toxicity of phalloidin in partially hepatectomized rats (1972)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 272 (1972), S. 447-449 
    Details
    ISSN: 1432-1912
    Keywords: Phalloidin ; Hepatectomy ; Regenerating Liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Toxicity of the mushroom cyclopeptide phalloidin decreases after partial hepatectomy. Nevertheless all morphological signs of intoxication are detectable in livers from dead or surviving animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501251
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    Paper (German National Licenses)
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