ISSN:
1439-6327
Keywords:
Adrenergic beta receptor Agonists
;
Adenosine triphosphatase
;
Potassium
;
Sodium
;
Erythrocytes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary β-adrenoceptor stimulation in vivo shifts potassium into the cells. To examine whether human erythrocytes participate in this process, we measured, along with serum or plasma potassium, the concentrations of potassium and sodium in erythrocytes. β-adrenoceptor stimulation was obtained by infusion of either fenoterol or hexoprenaline into 6 volunteers at rest or by endogenous amines provoked in 14 volunteers during ergometric exercise. Metabolic effects were followed at rest on serum insulin, Cpeptide, and growth hormone levels, and during exercise on pH and on lactate concentration in blood. The potassium concentration (mean ±S.E.M.) dropped (p〈0.001) in serum from 4.64±0.37 to 3.19±0.43 mmol·l−1 in the first hour at rest and in plasma from 5.70±0.93 to 4.63±0.45 in 90 sec directly after exercise. The concentration of erythrocyte sodium dropped (p〈0.001) from 9.68±0.73 to 8.81±0.62 mmol·l−1 in cells and from 9.62±1.16 to 8.55±1.24 during exercise for 90 s, respectively. Changes in the concentration ratio of cellular sodium to potassium confirmed this sodium shift. An increased sodium transport in erythrocytes due to β-adrenoceptor stimulation in vivo appears to complement a shift of serum potassium into the cells and may be mediated by the membranebound sodium, potassium ATPase.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00417762
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