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  • 1
    Electronic Resource
    Electronic Resource
    Treatment of steroid-dependent asthma with recombinant interferon-gamma (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have recently reported that treatment of patients with severe atopic dermatitis with recombinanl interferon-gamma (rIFN-y) resulted in clinical improvement as well as a reduction of circulating eosinophils. Since IgE-dependent late phase allergic reactions and eosinophilic infiltration are thought to play an important role in the pathogenesis of asthma, we conducted a two centre randomized double-blind placebo-controlled trial of rIFN-y in the treatment of steroid-dependent asthma. Patients were treated with daily subcutaneous injections of either 0.05 mg/m2 rIFN-y (n= 9) or placebo (n=11) for 90 days. All patients completed the study without significant drug toxicity noted. Oral prednisone dose, forced expiratory volume in 1 second (FEV), peak expiratory flow rates (PEFR) and circulating eosinophil counts were monitored throughout the trial. There was no significant difference between the two treatment groups in per cent reduction from baseline of daily prednisone (P=0.51). There was also no significant difference between the two treatment groups in per cent change from baseline in FEV1 (P= 0.54)or in PEFR (P=0.75). Total circulating eosinophil counts decreased by 31% in the rIFN-y group and increased by 8.5% in the placebo group (P= 0.09). We conclude that this treatment regimen was not effective in patients with steroid-dependent asthma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1993.tb00367.x
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  • 2
    Electronic Resource
    Electronic Resource
    Identification of neonatal grey lethal mice (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 176 (1973), S. 273-278 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The grey lethal mouse is an osteopetrotic mutant which cannot be identified by its external appearance (grey fur) until eight days of age and dies within one month of birth. Techniques for the identification of neonatal mutants would greatly facilitate study of the pathogenesis of osteopetrosis and its early treatment.Under hypothermal anesthesia, the left lower limbs of neonatal mice were amputated just above the knee joint. The external appearance of two day old amputated tibiae could be correlated with the external appearance of the mice at eight days of age. The diaphyses of normal tibiae appeared red under the dissecting microscope due to the presence of hemopoietic tissue occupying the central marrow cavity. Grey lethal tibiae appeared opaque because relatively more unresorbed bone occupied the center of the diaphysis.Histologic examination showed that in normal mice at birth, the mandibular incisor extended posteriorly to the molar region of the jaw, but that in grey lethals dense bone prevented the incisor from growing posteriorly in this fashion.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091760303
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    Paper (German National Licenses)
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