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  • 1
    ISSN: 1432-1246
    Keywords: Diesel exhaust emission ; Liver ; Electron microscopy ; Freeze-fracture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The livers of Syrian golden hamsters were examined with the light and electron microscope using the techniques of thin sectioning and freeze-fracture following 5 months of exposure to various concentrations of diluted diesel exhaust gases. The light microscopical examination showed enlarged sinusoides with activated Kupffer's cells and slight changes in the cell nuclei. In the electron microscopical examination the most striking changes were seen in the mitochondria, which frequently showed a loss in cristae. In addition, the mitochondria exhibited pleomorphic character. The microbodies were of the same size as mitochondria. An increase in the number of lysosomes was observed especially in the tissue surrounding the narrow bile canaliculi. The various alterations corresponding to the different concentrations of exhaust gases could be seen especially well in the sinusoides, the mitochondria and the microbodies. In general the hepatocytes appeared to be moderately enlarged. The zonulae occludentes showed a more irregular outline and large maculae tight junctions were found on the lateral region of the plasmalemma of hepatocytes. The gap junctions exhibited a wide range of structural diversity. The intramembranous particles on the P fracture face of the plasmalemma of hepatocytes are aggregated.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Transplant international 12 (1999), S. 33-41 
    ISSN: 1432-2277
    Keywords: Key words Heart transplantation ; partner relationship ; Partner relationship ; heart transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Terminal heart disease affects not only the patient, but also members of the patient's family, and especially the spouse. The aim of this prospective study of 26 couples was to collect information about the impact of heart transplantation on the partner relationship. Data were collected from patients and spouses when the patients were placed on the waiting list for transplantation, 1 year postoperatively, and 5 years postoperatively. The Family Assessment Measure (FAM III), a self-report instrument that provides quantitative indices of family functioning on seven interacting dimensions, was used. In the course of the transplant process, both patients and spouses reported a significant deterioration in the partner relationship in general. While patients perceived only one clear-cut point of conflict – communication about emotions – as crucial, the spouses reported a significant worsening in role performance, communication, emotional involvement, and values and norms. These changes were discernible 1 year after transplantation and persisted for at least 5 years. We conclude that heart transplantation has a significant negative impact on the partner relationship 1–5 years after transplantation. Consequently, more attention should be paid to all aspects of the partner relationship in a holistic approach to the treatment of heart transplant recipients and their partners.
    Type of Medium: Electronic Resource
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