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  • 1
    Electronic Resource
    Electronic Resource
    THE TOXICITY OF ACTINOMYCIN D (1960)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 89 (1960), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1960.tb20158.x
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  • 2
    Electronic Resource
    Electronic Resource
    Needle tract recurrences after closed biopsy for sarcoma: Three cases and review of the literature (1997)
    Springer
    Annals of surgical oncology 4 (1997), S. 228-236 
    Details
    ISSN: 1534-4681
    Keywords: Biopsy ; Sarcoma ; Needle biopsy ; Malignant neoplasm ; Recurrence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Percutaneous closed needle biopsy of musculoskeletal neoplasms has gained in popularity. However, it remains controversial whether or not to resect the needle tract for fear of a local recurrence. A single published case report exists, noting the lone tract recurrence of an extremity skeletal osteosarcoma. Methods: We report on three additional individuals who demonstrated that tract local recurrences may occur after a closed needle biopsy for nonosteosarcoma, nonextremity sarcomas. For perspective, the world literature is reviewed to identify tract recurrences for other malignancies and the results of needle biopsy in musculoskeletal neoplasms. Results: Eighty-nine percent of needle tract local recurrences occur when carcinomas are subjected to biopsy, as reported in the literature. Forty-seven cases since 1950 are described representing essentially all tumor types. The nature of musculoskeletal neoplasms makes closed biopsy more difficult than for softer, more homogeneous, and easier to access neoplasms. Conclusions: Local recurrences of sarcoma may occur in closed needle biopsy tracts. Strong consideration should be given to open biopsy and tract resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02306615
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  • 3
    Electronic Resource
    Electronic Resource
    An analysis of concordance among hospital databases and physician records (1998)
    Springer
    Annals of surgical oncology 5 (1998), S. 553-556 
    Details
    ISSN: 1534-4681
    Keywords: Database ; Oncology ; Concordance ; κ statistic ; Orthopaedics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Hospital databases contain vital demographic patient information, which is increasingly being used as a basis to dictate care. It is hypothesized that the validity of data administratively generated from such sources is suboptimal, especially for rare subspecialties. The authors examined three databases to determine their concordance in an academic orthopaedic oncology subspecialty practice. Methods: A 2-year retrospective review was performed on three databases searching for seven fundamental variables: additions/deletions; identification number; birthdate; procedure date; admit/discharge date; procedure code; and diagnostic code. Two university-maintained hospital databases (medical records and physician billing) were compared to the surgeon's personal handwritten daily log, which served as the “gold standard.” Results: All seven variables were in agreement with the physician's log in only 60% of the medical records and 61% of the physician billing patient entries (n=564). On more detailed statistical analysis using x2, cross tabulations, and the κ statistic for interobserver agreement, it was determined that poor concordance exists among the databases. Conclusion: Surgeons delivering quartenary care should maintain his or her own database because the hospital's information often differs on one or more important variables. Further investigation into the accuracy of hospital databases regarding commonly practiced medical disciplines appears warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02303650
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  • 4
    Electronic Resource
    Electronic Resource
    Telomerase activity in skeletal sarcomas (1998)
    Springer
    Annals of surgical oncology 5 (1998), S. 627-634 
    Details
    ISSN: 1534-4681
    Keywords: Telomerase activity ; Skeletal sarcomas ; Osteosarcomas ; TRAP assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Telomerase is a ribonucleoprotein that adds TTAGGG nucleotide repeats onto the ends of eukaryotic chromosomes to maintain telomere integrity. Somatic cells do not express telomerase and stop dividing when the chromosomal ends are shortened critically after many cell divisions. Immortal cell lines and cancer cells apparently have telomerase activity that contributes to an unlimited number of cell cycles. The purpose of our study is to investigate whether telomerase activity is expressed in primary malignant tumors of the skeletal system when compared to adjacent normal tissue. Methods: Fresh tumor and normal tissue was collected from 14 patients (10 males, 4 females; age range, 8 to 76 years) and protein extraction performed. The tumors included seven osteosarcomas (three examined before and after chemotherapy), two chondrosarcomas, two spindle cell tumors, one hemangiopericytoma, one chordoma, and one adamantinoma. Telomerase activity was analyzed by using a highly sensitive polymerase chain reaction (PCR)-based assay (telomere repeat amplification protocol [TRAP]). Results: Telomerase activity was found in 8 of 14 sarcoma patients (57%) using the TRAP assay. Compared to HeLa cell extract (positive control), telomerase activity in the tumor specimen ranged from 0 (in osteosarcoma) to 11.7% (in hemangiopericytoma). There was variation in the number of telomeric repeats generated by telomerase. At least five telomeric bands (e.g. 50, 56, 62, 68, 74 bp) in a ladder pattern had to be present before telomerase activity was considered positive in our analysis. Conclusions: Telomerase activity may be an oncogenic sustaining event helping to maintain the transformed phenotype seen in malignant tumors of the bone. The degree of telomerase activity varies among skeletal malignancies, but was less than that observed in HeLa cells. The majority of osteosarcomas showed no telomerase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02303833
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  • 5
    Electronic Resource
    Electronic Resource
    Microsatellite instability in sarcomas (1998)
    Springer
    Annals of surgical oncology 5 (1998), S. 356-360 
    Details
    ISSN: 1534-4681
    Keywords: Microsatellite instability ; Musculoskeletal oncology ; Musculoskeletal sarcoma ; Neoplasm ; PCR ; Sarcoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Microsatellite instability (MIN) has been studied in a variety of carcinomas and gynecologic sarcomas, but never in musculoskeletal sarcomas. Methods: We evaluated 16 skeletal and soft tissue sarcomas at nine genetic loci from chromosomal regions 1q, 5q, 7q, 12p, 13q, 17p, 19q, and two at 11p—all potential regions of interest regarding musculoskeletal sarcomas. Results: MIN was identified at one or more loci in seven of the cancers studied (44%). Three tumors had more than one locus with MIN and one tumor, a high-grade osteogenic sarcoma, had five of nine loci positive for MIN. Conclusion: These results indicate that musculoskeletal sarcomas show instability in areas inside and outside the loci of known oncogenes. Areas of mismatch repair, as heralded by MIN, may contribute to the vast heterogeneity of these neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02303500
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  • 6
    Electronic Resource
    Electronic Resource
    Rotation-plasty: Surgical technique of resection and reconstruction in the treatment of osteosarcoma about the knee in children (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Clinical Anatomy 1 (1988), S. 105-116 
    Details
    ISSN: 0897-3806
    Keywords: rotation-plasty ; osteosarcoma ; limb-salvage ; resection ; reconstruction ; knee ; children ; Life and Medical Sciences ; Miscellaneous Medical
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Resection of malignant tumors about the knee, followed by reconstruction of the lower limb by rotating it through an arc of 180 degrees is becoming a popular method of treatment of osteosarcoma in growing children. Following rotation, the rotated ankle functions as the knee joint, powering a custom-made prosthesis. The functional result is superior to above-knee amputation with better propioceptive feedback and the absence of phantom limb pain. The children are able to climb stairs well and participate in running sports.The surgical technique is demanding, requiring a precise knowledge of the surgical anatomy. To be successful, the sciatic, peroneal, and tibial nerves must be preserved. The femoral and popliteal artery may be resected and reconstructed if necessary. The remaining growth of the child is determined so that the rotated ankle can be positioned at the level of the contralateral normal knee.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ca.980010204
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  • 7
    Electronic Resource
    Electronic Resource
    Evaluation methods for ablative plastics. A review of the techniques used (1963)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 3 (1963), S. 238-250 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A determination of the performance indices of ablative plastics is indeed a formidable task because of the severity of the high-temperature test environment, nonstandard test methods, limitations of available evaluation facilities and the complex interrelationship between materials performance and environmental parameters. In spite of these difficulties, considerable progress has been made in establishing new test methods for evaluating very high-temperature (ablative) plastics. This article describes the test facilities and measurement techniques available for obtaining research and design data on ablative plastics.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760030403
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