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  • 1
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    Dordrecht : Periodicals Archive Online (PAO)
    Erkenntnis. 40:1 (1994:Jan.) 21 
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Erkenntnis 40 (1994), S. 21-42 
    ISSN: 1572-8420
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy
    Notes: Abstract The paper addresses the widely held position that the Third Man regress in theParmenides is caused at least in part by the self-predicational aspect of Plato's Ideas. I offer a critique of the logic behind this type of interpretation, and argue that if the Ideas are construed as genuinely applying to themselves, then the regress is dissolved. Furthermore, such an interpretation can be made technically precise by modeling Platonic Universals as non-wellfounded sets. This provides a solution to the Third Man regress, and allows a consistent reading of both self-predication and the singularity of the respective Forms.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 321 (1992), S. 342-347 
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 10 (1995), S. 475-477 
    ISSN: 1437-9813
    Keywords: Choledochal cyst ; Sex-linked anomaly ; Hereditary disease ; Common channel theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The well-known observation that females have a much higher incidence of choledochal cysts than males suggests that this may be a sex-linked hereditary disease. However, up to now there have been no familial case reports in the literature. The author describes a sex-linked familial case. Both, the mother and her single daughter suffered from a type I choledochal cyst with a narrow segment and amylase-negative bilious fluid in the cyst. In order to lend support to the plausibility of a hereditary disease, blood types, histocompatibility, and chromosome status were investigated. Although their blood type was the same (A1 positive) and histocompatibility antigens were only slightly different, we could not detect a chromosomal defect in either mother or child and could not find any association with other malformations. Despite these implications against the possibility of a hereditary disease, it should be noted that in both patients the nature of the choledochal malformation was the same, especially with regard to the spastic inferior choledochal sphincter (= narrow segment) and the amylase-negative bile. Regarding the forms of choledochal dilatation, the author presumes that types I, IV, and V have a different pathogenesis than types II and III.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 16 (2000), S. 351-355 
    ISSN: 1437-9813
    Keywords: Key words Extrahepatic biliary atresia ; Hepatoportoenterostomy ; Prognosis ; Long-term results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Clinical and histologic findings from 206 patients operated upon for extrahepatic biliary atresia (EHBA) are analyzed in order to define the prognosis of patients with EHBA. The prospective study took into consideration both initial fibrosis of the liver and the morphology of the porta hepatis (PH) at surgery. Kaplan-Meier survival estimates and statistical calculations demonstrated a relationship between long-term survival and histologic findings in the liver and porta hepatis. The efficacy of HPE is significantly influenced by the morphology of the PH and to a lesser extent by the initial liver fibrosis. Surgery should thus achieve pattern 1 morphology of the PH, but this is problematic because of the close relationship of the vascular and biliary structures in its two lateral zones.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 1 (1986), S. 30-36 
    ISSN: 1437-9813
    Keywords: Bile duct atresia ; Hepatic portoenterostomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since 1972, 64 infants suffering from extrahepatic bile duct atresia have been examined in our Department. Between 1975 and 1984 conventional or extended hepatic-portoenterostomy was performed on 41 patients. These infants were classified into two groups on the basis of age at the time of surgery in relation to the duration of cholestasis. Of 12 patients operated upon 5 or more years ago, 8 (66%) are still alive with favorable bile flow and 4 (34%) have died from hepatic failure caused by biliary cirrhosis. Of 22 infants above 8 weeks of age who have been treated so far, 7 (31%) are alive with good bile flow and 15 (69%) have died within the past 3 years. In contrast, 12 (63%) of 19 infants operated upon before 8 weeks of age are healthy with good bile flow and only 7 (37%) have died from cirrhosis. The course of the disease was analyzed with regard to the following findings: (1) age at surgery with respect to the duration of cholestasis; (2) extent of liver fibrosis at surgery; (3) cross-section of ductular structures in the porta hepatis; (4) numerical and morphological changes in the interlobular bile ducts; (5) extent of dissection of the porta hepatis; (6) postoperative hepatoportitis. Principles determining the long-term follow-up of this dynamic obliterative process can be deduced from these investigations. Accordingly, a favorable prognosis can be expected if the following conditions are fulfilled: no cholestasis for more than 6 weeks; low-grade fibrosis at the time of surgery, with a mean diameter of the ductular structures in the porta hepatis of more than 450 μm; no numerical or morphological alterations in the interlobular bile ducts; no postoperative “hepatoportitis”.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 16 (2000), S. 182-188 
    ISSN: 1437-9813
    Keywords: Key words Peritonitis ; Perforated appendicitis ; Endotoxin ; Surgical measures ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pathogenesis of peritonitis due to hollow-viscus perforation is currently accepted as being mainly based on the local and systemic release of pro- and anti-inflammatory mediators triggered by the presence of bacteria and bacterial products in the abdominal cavity. Therefore, treatment consists in focal restoration, intraoperative debridement and lavage, and postoperative measures such as drainage, continuous peritoneal lavage, or scheduled reoperation aiming at the removal of infectious agents from the peritoneal cavity to prevent persisting peritonitis and sepsis. In order to evaluate the pathophysiologic relevance of the bacterial and endotoxin load of the peritoneal exudate, we examined the peritoneal fluid of 20 children with perforated appendicitis for qualitative and quantitative analysis of bacteria, antibiotic concentrations, and endotoxin content. The time period ranged in 12-h intervals from intraoperatively to day 5. Eighteen of 20 fluid specimens (90%) showed endotoxin levels above 1.5 endotoxin units EU/ml (standard 〈0.1 EU/ml). The most common bacterial species isolated was Escherichia coli, mostly in high concentrations. Despite persisting high endotoxin concentrations and bacterial loads in the peritoneal cavity during the 5 postoperative days, the children recovered uneventfully and the systemic signs of infection disappeared rapidly. In conclusion, neither the bacterial nor the endotoxin load of the peritoneal cavity proved to be associated with the clinical course. Therefore, we hypothesize that during peritonitis compartmentalization of the focus of infection prevents further systemic reactions and ultimately leads to removal of the infectious agents by endogenous mechanisms. At least in peritonitis due to perforated appendicitis in children, adjuvant surgical measures in addition to appendectomy and intraoperative debridement are not necessary.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Pediatric surgery international 9 (1994), S. 268-273 
    ISSN: 1437-9813
    Keywords: Rhabdomyosarcoma ; Biliary tree ; Major resection ; Chemotherapy ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Embryonal rhabdomyosarcoma of the biliary tree is a very rare tumor. Only 56 patients have been reported in the literature; 17 of them were long-term survivors. The recommended therapy is multidisciplinary: according to the Intergroup Rhabdomyosarcoma Study I and II (IRS I and II), the combination of major resection, chemotherapy, and radiation of the porta hepatis could improve the results. This report reviews our experience with four consecutive patients from a surgical point of view. We conclude that the classical definition of resectability cannot be applied to rhabdomyosarcomas of the biliary tree, because these polypoid tumors as a rule extend into the liver sectors and often affect both halves of the liver. Major resection with atypical reconstruction of the biliary tree is necessary in order to provide some promise of success. The problem of preoperatively determining the extent of the tumor is very important, as even intraoperative cholangiography cannot accurately demonstrate the true dimensions of the tumor in the sectorial bile ducts. The advantages and disadvantages of the procedures that come into question are discussed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 349 (1970), S. 138-151 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bericht über 6 juvenile Fibromatosen mit 20 bioptisch kontrollierten Neubildungen. Das Ergebnis der morphologischen Vergleichsuntersuchungen bei durchschnittlich 6jähriger Beobachtungszeit wird mitgeteilt und der Versuch unternommen, die Stellung der Fibromatosen im System mesenchymaler Erkrankungen zu präzisieren.
    Notes: Summary Six cases of juvenile fibromatoses with 20 neoplasms controlled by biopsy are reported. The result of compared morphologic investigations in shown during an average observation period of six years; further it has been tried to state precisely the fibromatoses position in the mesenchymalic lesions system.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The content of chlorinated hydrocarbons (CHC) was determined by means of capillary column gas chromatography in samples of fat tissue from 183 healthy children, 46 children with malignant tumors and 33 children with benign tumors or congenital malformations. The highest concentrations were found for total polychlorobiphenyls (PCB) (−x=1.614 ppm), followed by the DDT group (−x=0.556 ppm, HCB (−x=0.097 ppm), the HCH isomers (−x=0.083 ppm), dieldrin (−x=0.020 ppm) and total heptachlor (−x=0.010 ppm). Neonates displayed high concentrations in the adipose tissue before, the first uptake of food. In the first six months of life, the concentrations of total PCB, the individual PCB components as well as DDT and HCB decreased significantly. In the second year of life, they rose again to the initial values and then remained relatively constant during the rest of childhood. The regional differences with regard to total CHC residues were slight, so that the CHC exposure cannot be reduced by a change of domicile within West Germany (FRG). Children with congenital malformations or benign or malignant tumors do not display raised concentrations of CHC.
    Type of Medium: Electronic Resource
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