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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 51 (1996), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Auditory evoked potentials have been used as an indicator of awareness. In the present study we combined epidural analgesia with three techniques of general anaesthesia. Motor signs of intra-operative wakefulness were documented and assessed along with cardiovascular changes and with midlatency auditory evoked potentials. Thirty patients undergoing elective laparotomy were studied as follows: first continuous epidural analgesia was used in all patients to block painful sensation to the level of T5. Intravenous general anaesthesia was induced with propofol (2.5 mg.kg-1 b.w., group 1, n = 10), thiopentone (5 mg.kg-1 b.w., group 2, n = 10) or etomidate (0.2 mg.kg-1 b.w., group 3, n = 10) and maintained with a propofol (3–5 mg.kg-1, group 1), isoflurane (0.4-0.8 Vol%, group 2), flunitrazepam and fentanyl (0.005 mg.kg-1 b.w.) bolus injection every 20 to 30 s (group 3). Heart rate and arterial pressure were recorded continuously. Purposeful movements of the limbs, eye-opening or other movements as well as coughing were documented as motor signs of intra-operative wakefulness. Auditory evoked potentials were recorded in the awake state, after induction and during maintenance of general anaesthesia. Motor signs of intra-operative wakefulness occurred statistically significantly more often in the patients of the flunitrazepam/fentanyl group than in those of the propofol and isoflurane group. There was no correlation between wakefulness and cardiocirculatory parameters. In the awake patients midlatency auditory evoked potentials had high peak to peak amplitudes and a periodic waveform. After induction of general anaesthesia with propofol, thiopentone and etomidate as well as during maintenance of general anaesthesia with propofol and isoflurane, midlatency auditory evoked potentials were severely attenuated or abolished. In contrast, during maintenance of general anaesthesia with flunitrazepam/fentanyl midlatency auditory evoked potentials reestablished high peak to peak amplitudes. The persistence of midlatency auditory evoked potentials coincides with a high incidence of motor signs of wakefulness. During the combination of regional and general anaesthesia, isoflurane and propofol seem to provide better suppression of motor signs of wakefulness than the intermittent bolus injection of flunitrazepam/fentanyl.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 49 (1994), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of thiopentone on the middle latency auditory evoked potentials was investigated in 12 patients during induction of anaesthesia with thiopentone 5 mg.kg-1. 100% oxygen was administered throughout the induction, and when the patient moved purposefully a further bolus (2 mg.kg-1) was given, and anaesthesia continued in the normal way. The middle latency auditory evoked potentials were elicited before and during the induction. Binaural clicks (70 dB above normal hearing threshold) were presented at a rate of 9.3 per s. Averages of 1000 responses were analysed off line, and a fast Fourier transformation of the middle latency auditory evoked potentials were used to calculate the power spectrum of the averages. Awake, the patients had large peak to peak amplitudes and a normal waveform. The power spectra showed a high energy between 30-40 Hz. After induction the latencies of waves Na, Pa, Nb and PI and the amplitudes of the waves Na/Pa, Pa/Nb, and Nb/PI were decreased or completely attenuated. Both effects lasted for 4 min. When movement occurred (after 4–6 min), the values returned to awake. The second bolus repeated the changes.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We studied the effects of increasing end-expiratory concentrations of isoflurane (0.3, 0.6, 0.9, 1.2 vol.%) (n = 12 patients), desflurane (1.5, 3.0, 4.5, 6.0 vol.%) (n = 12 patients) and sevoflurane (0.5, 1.0, 1.5, 2.0 vol.%) (n = 12 patients) on power spectral analysis of the electroencephalogram (EEG). Spectral edge frequency (SEF), total power (TP) and relative power in the delta, theta, alpha and beta band were calculated. EEG changes were very similar within the three groups. SEF decreased, TP and relative power in the delta and theta band increased, power in the beta band decreased in a dose-dependent fashion with comparable regression lines. This indicates that MAC equivalent administration of isoflurane, desflurane and sevoflurane in clinically applied dose ranges is associated with equipotent EEG suppression.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: During general anaesthesia, midlatency auditory evoked potentials are suppressed in a dose dependent manner by a number of general anaesthetics. The activating effects of surgical stimuli on midlatency auditory evoked potentials have been demonstrated during light inhalational anaesthesia, and indicate that midlatency auditory evoked potentials reflect the activity of the central nervous system and not only anaesthetic concentrations. We investigated the effect of surgical stimulation (skin incision, sternotoniy) on midlatency auditory evoked potentials under high dose opioid analgesia in 30 patients undergoing elective cardiac surgery. High dose opioid analgesia was maititained using fentanyl (1.2 mg.h−1) and combined with either propofol (4-8 mg.kg−1.h−1) (group I, n = 10), isoflurane (0.6-1.2 vol%) (group II, n = 10) or flunitrazepam (1.2 mg.h−1) (group III. n = 10). Midlatency auditory evoked potentials were recorded in the awake state, during general anaesthesia before skin incision, after skin incision and after sternotoniy. During general anaesthesia there were marked statistically significant increases in latencies and decreases in amplitudes of midlatency auditory evoked potentials in the propofol/fentanyl and isoflurane/fentanyl groups. In contrast, in the flunitrazepam/fentanyl group there were only small changes of midlatency auditory evoked potentials. The latencies of the early cortical potentials were similar to those in the awake state. After skin incision as well as after sternotomy no significant changes of midlatency auditory evoked potentials could be observed in any of the experimental groups. These results indicate that activation of the auditory pathway by surgical stimuli may be blocked when analgesia is provided by high dose fentanyl. Furthermore, midlatency auditory evoked potentials may be preserved during surgical analgesia as demonstrated in the flunitrazepam/fentanyl group, whereas they were suppressed during propofol/fentanyl and isoflurance/fentanyl. Propofol (4-8 mg. kg−1.h−1) or isoflurane (0.6-1.2 vol%) seem to be superior to flunitrazepam (1.2 mg.h−1) in their potency to suppress the auditory pathway during surgical analgesia with fentanyl.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Consciousness and Cognition 3 (1994), S. 129-147 
    ISSN: 1053-8100
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Psychology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Psychophysiology 11 (1991), S. 55 
    ISSN: 0167-8760
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1433-044X
    Keywords: Key words Multiple blunt trauma • Quality management • Guidelines • Algorithm ; Schlüsselwörter Polytrauma • Qualitätsmanagement • Behandlungsleitlinien • Algorithmus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Optimierung der Akutversorgung Polytraumatisierter erfolgte im Jahre 1994 die Einführung von problem- und prioritätenorientierten Behandlungsleitlinien (Polytraumaalgorithmus) in der eigenen Klinik. Die Bedeutung dieser Behandlungsleitlinien wurde vergleichend für 2 prospektiv erfaßte Kollektive 4/1988–12/1993 (A ; n = 126) und 1/1994–6/1996 (B; n = 74) analysiert. Anhand neun definierter Parameter wurde der Versorgungsablauf der frühklinischen Polytraumabehandlung beurteilt. Für alle 9 Beurteilungsparameter zeigten sich Verbesserungen nach Einführung des Algorithmus (Kollektiv B) gegenüber der Kontrollgruppe: 1. Vollständige radiologische und sonographische Basisdiagnostik bei 97 vs. 91 % der Patienten; 2. Dauer von 38 vs. 55 min bis zum kraniellen CT bei schwerem SHT (GCS 〈 10); 3. Reduktion verzögert diagnostizierter Läsionen auf 5 vs. 32 %; 4. Dauer von 16 vs. 20 min bis zur Intubation; 5. Dauer von 23 vs. 30 min bis zur Thoraxdrainage; 6. Dauer von 18 vs. 32 min bis zur Transfusion bei Schock; 7. Dauer von 79 vs. 98 min bis zur Notoperation bei Schock; 8. Dauer von 95 vs. 124 min bis zur Trepanation; 9. Operationsrate innerhalb von 24 h nach ICU-Aufnahme von 3 vs. 11 %. Die Letalitätsraten der Kollektive wurden nach Unterteilung in 3 Gruppen (I–III) mit mittlerer (ISS: 18–24), hoher (ISS: 25–49) und sehr hoher (ISS: 50–75) Verletzungsschwere gegenübergestellt. ISS-Werte, Alter, initiale Bewußtlosigkeit und Schock waren in allen Gruppen für beide Kollektive vergleichbar (mit Ausnahme einer höheren Verletzungsschwere von Kollektiv B in Gruppe I). In allen Gruppen zeigte sich ein deutlicher Rückgang der Letalität für das Kollektiv B. Gruppe I: 0 vs. 20 %, (p 〈 0,05); Gruppe II: 8 vs. 24 %, (p 〈 0,05); Gruppe III 40 vs. 71 %, aufgrund niedriger Fallzahl (n = 5) in B nicht signifikant. Durch Behandlungsleitlinien konnten Versorgungsabläufe optimiert und Behandlungsergebnisse verbessert werden. Um solche Leitlinien in ihrer Gültigkeit und Praktikabilität regelmäßig zu überprüfen, sowie gleichzeitig die Qualität weiter zu optimieren, ist eine kontinuierliche Überprüfung der Behandlung im Sinne eines Qualitätsmanagementsystems zu fordern.
    Notes: Summary To enhance the quality of treatment of patients with multiple injuries (blunt trauma), guidelines for the acute clinical management (trauma-algorithm) were implemented at our clinic in 1994. The impact of these guidelines was analysed, comparing two prospectively recorded collectives of polytraumatized patients 4/1988–12/1993 (A; n = 126) and 1/1994–6/1996 (B; n = 74). Nine specifically defined parameters were used to assess the therapeutic process of early clinical trauma management. All parameters showed an improvement after implementation of the algorithm (group B): (1) Complete radiological and sonographic basic diagnostics in 97 % vs. 92 % of patients; (2) time interval of 38 min vs. 55 min until cranial CT was done after severe head injury (GCS 〈 10); (3) reduction of delayed diagnosis of lesions to 5 % vs. 24 %; (4) duration of 16 min vs. 20 min until intubation; (5) period of 23 min to 30 min to pleural drainage; (6) duration of 18 min vs. 32 min until transfusion in shock; (7) period of 79 min vs. 98 min until emergency operation in shock; (8) duration of 95 min vs. 124 min until trepanation, and (9) operation rate within 24 h after admission to ICU in 3 % vs. 12 %. The lethality rates of each collective were assessed after subdivision in three groups (I–III) with middle (ISS: 18–24), high (ISS: 25–49) and extreme (ISS: 50–75) injury severity. In all groups of both collectives ISS values, age, initial loss of consciousness (GCS) and shock were comparable (except the higher injury severity of collective B in group I). In all groups a reduction of lethality could be shown for collective B: Group I, 0 % vs. 20 % (P 〈 0.05); group II, 8 % vs. 24 % (P 〈 0.05); and group III, 40 % vs. 71 %, not significant because of the small group in B (n = 5). The implementation of therapeutic management guidelines led to an improvement of both treatment processes and outcome. In order to regularly reassess validity and practicability of such guidelines as well as further enhance therapeutic quality, a continuous evaluation programme representing a quality management system should be inaugurated.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 48 (1999), S. 108-115 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Anästhesie ; Ambulante Patienten ; Präoperative Untersuchungen ; Routineuntersuchungen ; Key words Anaesthesia ; Outpatient anaesthesia ; Preoperative diagnostic ; Routine screening investigations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The volume of preoperative screening investigations for outpatient anaesthesia ranges from few, selectively ordered investigations to extensive routine diagnostic procedures. It seem appropriate to reevaluate benefit and efficacy of routine preoperative assessment programs. The purpose of preoperative diagnostic is to assess the risk of anaesthesia and surgery for the patient. As shown by a number of studies, preoperative screening investigations seldom disclose new pathological findings of clinical relevance. Abnormal laboratory results in otherwise healthy patients rarely alter the anaesthetic management of the patient and are not related to perioperative complications. Extensive use of costly diagnostic procedures considerably increases health care budgets. A more selective approach to order preoperative investigations promises considerable savings. To achieve costeffective evalulation an efficient organisation of properative assessment must be established to avoid costly delay and on-day-of-surgery-cancellations. There is no medicolegal obligation to perform routine diagnostic testing. The anaesthetist must be sufficiently informed in time to assess the perioperative risk of the patient and to alter anaesthetic management as necessary. According to the presented studies a clinical history and a thorough physical examination represent an effective method of screening for the presence of disease. Careful medical history evaluation and physical examination can avoid extensive investigations in apparently healthy individuals and the latter should only be ordered if indicated.
    Notes: Zusammenfassung Die Bandbreite präoperativer Untersuchungen bei Patienten mit ambulanter Anästhesie variiert von wenigen, nur selektiv angeforderten Untersuchungen hin bis zu einem umfassenden Routineuntersuchungsprogramm. Nicht zuletzt aufgrund finanzieller Erwägungen erscheint es sinnvoll, den Nutzen und die Effektivität von routinemäßig durchgeführten Untersuchungen erneut kritisch zu bewerten. Durch präoperative Diagnostik sollen Zustände erkannt werden, die ein relevantes perioperatives Risiko darstellen. Präoperative Screeninguntersuchungen decken aber nur selten relevante pathologische Veränderungen auf. Pathologische Befunde lassen außerdem häufig therapeutische Konsequenzen vermissen und stehen in keinem Zusammenhang mit perioperativen Komplikationen. Vielmehr zeigt sich, daß das perioperative Risiko von ambulanten Patienten gut durch eine ausführliche Anamnese und sorgfältige körperliche Untersuchung abgeschätzt werden kann. Unter diesen Voraussetzungen erscheint es den Autoren gerechtfertigt, auf standardisierte Untersuchungsprogramme bei ambulanten Patienten zu verzichten und sich nach den Erfordernissen des Einzelfalls zu richten.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Intraoperative Wachheit ; Allgemeinanästhesie ; Key words Anaesthesia ; Intraoperative awareness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The possibility that a patient during general anaesthesia is aware of the operation going on and aware of severe pain that might be remembered postoperatively must be very alarming to patients and anaesthetists alike. Furthermore, there is experimental evidence showing that conscious recall of intraoperative events is only the tip of an iceberg; it seems very probable that there is even a higher incidence of unconscious perception during general anaesthesia. Therefore, the following stages of intraoperative awareness must be distinguished: (1) conscious awareness with explicit recall and with severe pain; (2) conscious awareness with explicit recall but no complaints of pain; (3) conscious awareness without explicit recall and possible implicit recall; (4) subconscious awareness without explicit recall and possible implicit recall; (5) no awareness. The incidence of conscious awareness with explicit recall and severe pain has been estimated at less frequent than 1/3000 general anaesthetics. Conscious awareness with explicit recall but no complaints of pain has been reported in the literature with an incidence of 0.5–2%. With 7–72%, conscious awareness without explicit recall and possible implicit recall shows a very wide range of variation and its occurrence probably depends on the anaesthetic drugs used. Subconscious awareness with possible implicit recall has an incidence of up to 80%, but there are many methodological problems in demonstrating implicit memory of intraoperative events. Reports of intraoperative awareness do not come exclusively from cardiac surgery and obstetrics, but also from all other operative specialities. Postoperatively, patients who experienced intraoperative awareness may develop a so-called post-traumatic stress syndrome. Symptoms involve re-experiencing the event awake or in dreams, sleep disturbances, depression, avoidance of stimuli associated with the event. The probability of the development of the post-traumatic stress syndrome seems to coincide with the experience of severe pain. When a patient complains of intraoperative awareness postoperatively the anaesthesiologist should discuss the event frankly with the patient. When the symptoms of the post-traumatic stress syndrome persist a psychotherapy should follow. Causes for intraoperative awareness may be: equipment failure, too-light anaesthesia, e.g. for a caesarean section or for emergency surgery in severely injured or polytraumatized patients, during cardiac surgery, bronchoscopy or difficult intubation. There is interindividual variability in anaesthetic effect; for example, chronic drug or alcohol abuse or overweight may make increased anaesthetic doses necessary. They are at risk for intraoperative awareness. Some general anaesthetics or anaesthetic procedures, e.g. the combination of a relaxant and N2O, opioid mono-anaesthetics, or opioids combined with benzodiazepines, seem to involve a higher risk of intraoperative awareness than do volatile anaesthetics. The bases of litigation are medical malpractice, breach of contract by the anaesthesiologist or lack of informed consent from the patient. Therefore, patients who are at risk of intraoperative awareness should be given detailed information on this special risk before the operation.
    Notes: Zusammenfassung Man unterscheidet verschiedene intraoperative Wachheitsstufen, wie explizit erinnerbare bewußte Wachheit und Erleben von Schmerz, explizit erinnerbare bewußte Wachheit ohne Schmerzerlebnis, bewußte Wachheit mit Amnesie, unbewußte Wachheit mit impliziter Erinnerung und keine Wachheit. Die explizit erinnerbare bewußte Wachheit mit Schmerzerleben wird auf〈1:3000 Allgemeinanästhesien geschätzt. Die erinnerbare bewußte Wachheit ohne Schmerz wird in der Literatur mit 0,2–2% angegeben. Mit 7–72% weist die bewußte Wachheit mit Amnesie in Abhängigkeit von den verwendeten Anästhesieverfahren eine weit größere Streuung auf. Unbewußte Wachheit mit postoperativer impliziter Erinnerung wird ebenso aufgrund methodischer Schwierigkeiten recht unterschiedlich mit bis zu 80% angegeben. Postoperativ kann sich nach einer intraoperativen Wachepisode beim Patienten ein sog. posttraumatisches Streßsyndrom entwickeln. Ursachen intraoperativer Wachheit können sein: Fehlfunktion der Narkosegeräte, die flache Allgemeinanästhesie wie bei Sectio caesarea, der akuten Versorgung des polytraumatisierten Patienten, während herzchirurgischer Operation, Bronchoskopie und bei erschwerter Intubation. Narkoseverfahren wie die alleinige Kombination von Relaxans und Lachgas, die alleinige Verabreichung von Opioiden und/oder Benzodiazepinen sind mit einer besonders hohen Inzidenz intraoperativer Wachheitsfälle belastet. Grundlagen für die gerichtlichen Schritte sind ärztliche Behandlungsfehler oder die nicht vorliegende Aufklärung und Einwilligung des Patienten für ein solches Ereignis.
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