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  • 1
    Electronic Resource
    Electronic Resource
    Clinical Validation of a New Immunoradiometric Assay for Intact Human Osteocalcin (1999)
    Springer
    Calcified tissue international 64 (1999), S. 365-369 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Osteocalcin — Metabolic bone diseases — Global skeletal uptake — 99mTc-methylendiphosphonate — Biomarkers.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The purpose of this study was to estimate clinical validity of a new available immunoradiometric assay for circulating intact human BGP (N-tact Osteo SP) by measuring this protein in a large number of normal subjects and patients with the most common metabolic bone diseases. One hundred normal subjects were studied in order to obtain our normal ranges (4.9 ± 1.7 ng/ml). The mean values found in 28 patients with primary hyperparathyroidism (17.5 ± 22.8 ng/ml, P 〈 0.001), 15 glucocorticoid-treated patients (1.9 ± 1.5, P 〈 0.001), 10 patients with hypoparathyroidism (1.5 ± 0.7, P 〈 0.001), 9 with hyperthyroidism (8.3 ± 3.8, P 〈 0.001), 8 with skeletal metastases (7.2 ± 2.3, P 〈 0.001), and 4 with humoral hypercalcemia of malignancy (2.42 ± 1.91, P 〈 0.005) were significantly different from mean values found in normal subjects. Mean decrease of serum osteocalcin T-score values was significantly greater when evaluated by N-tact Osteo SP assay in 15 steroid-treated patients (−1.4 ± 1.0) and 19 primary hyperparathyroid (PHPT) patients (3.6 ± 1.9), compared with the mean values obtained with the Elsa-Osteo assay (−0.67 ± 1.2, P 〈 0.002 and 4.3 ± 2.8, P 〈 0.04, respectively). We found significant correlations between the global skeletal uptake of 99mTc-methylendiphosphonate and serum BGP levels assayed by both N-tact Osteo SP (P 〈 0.01) and Elsa-Ost-Nat assay (P 〈 0.05). Our results indicate that this new immunoradiometric assay for the intact human osteocalcin has the potential for good discrimination between normal subjects and patients with both low and high bone turnover. Furthermore, our findings emphasize the fact that, in the absence of available standardized commercial assays, one should rely on only one assay because different results are obtained by different assays under different clinical conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005815
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  • 2
    Electronic Resource
    Electronic Resource
    Aggregation of human peripheral blood mononuclear cells by calcium ionophore A23187. Comparison with the aggregation of platelets and defective response in Glanzmann's thrombasthenia (1988)
    Springer
    Inflammation research 24 (1988), S. 165-171 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Following exposure to calcium ionophore A23187, washed peripheral blood mononuclear cells (MNC) aggregated and formed thromboxane, like platelets. However, while aspirin strongly inhibited platelet aggregation and thromboxane formation, it had a little effect on the aggregation of MNC. In about 50% of the samples studied, aggregation of MNC was associated with the secretion of ATP. However studies in which exogenous ATP or ADP were used, suggested that the aggregation of MNC is independent of the secretion of nucleotides. MNC from 2 thrombasthenic patients failed to aggregate and bound 9–10 fold less radiolabelled fibrinogen than those from normals when challenged with A23187. However, fibrinogen, which plays a major role in the aggregation of platelets, did not appear to be involved in the aggregation of MNC. A differing behavior of these two types of cells was also found when the effect of plasma was studied on the aggregation response to A23187. Indeed, citrated plasma greatly enhanced the aggregation of platelets while it suppressed the response of MNC. This inhibitory effect of plasma was not detected when heparinized plasma was substituted for citrated plasma. We conclude that the aggregation of MNC in response to A23187 does not involve basic events known to play a major role in the aggregation of platelets. The response to A23187 may be an important probe for understanding basic mechanisms and pathophysiological significance of the aggregation of MNC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968096
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  • 3
    Electronic Resource
    Electronic Resource
    Cross-over study of muzolimine and hydrochlorothiazide-amiloride in hypertensive patients (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 241-244 
    Details
    ISSN: 1432-1041
    Keywords: muzolimine ; hydrochlorothiazide + amiloride ; antihypertensive treatment ; hypertensive patients ; side-effects ; serum potassium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Thiazide therapy is a widely used first line treatment for arterial hypertension. Its useful value, particularly in mild or moderate hypertension, is sometimes reduced by metabolic side-effects, as hypokalaemia and hyperuricaemia. In the present study the antihypertensive efficacy of a new, non-sulphonamide diuretic Bay g 2821 (muzolimine) was evaluated in comparison with the combination of hydrochlorothiazide-amiloride over a period of 4 weeks. A highly significant decrease in systolic and diastolic blood pressures was produced by both treatments. No decrease in serum potassium nor an increase in cholesterol, triglycerides, uric acid or glucose was detected during the 4 week treatment period. Subjective side-effects, such as headache and dizziness, were very rarely observed during Bay g 2821 treatment. The new diuretic appears, therefore, to be effective in the treatment of arterial hypertension without untoward side-effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543316
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  • 4
    Electronic Resource
    Electronic Resource
    Age-related changes assessed by peripheral QCT in healthy Italian women (2000)
    Springer
    European radiology 10 (2000), S. 609-614 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Bone mineral density – Forearm – Peripheral quantitative CT – Aging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to describe the normal cross-sectional pattern of radial bone loss associated with aging in healthy women and to generate a normative database using peripheral quantitative computed tomography (pQCT). Subjects with suspected conditions affecting bone metabolism or receiving any drugs affecting bone mineralization were excluded. The trabecular bone mineral density (BMD) and the total bone density of the ultradistal radius at the nondominant forearm was measured using the Norland-Stratec XCT-960 pQCT scanner in 386 healthy pre-, peri-, and postmenopausal females aged 15–81 years. The long-term in vivo precision error was 1.6 % CV (coefficient of variation) for trabecular and 0.8 % CV for total BMD measurements. The highest value of trabecular and total BMD measured was observed at the age group 15–39 years. Beyond these ages both trabecular and total BMD showed a linear decline with aging, decreasing by an overall slope of −1.28 and −0.55 mg/cm3 per year for total and trabecular BMD measurements, respectively. The test of parallelism between the regression slopes of the peri- and postmenopausal women showed a statistically significant difference for total BMD measurement (p = 0.003). Measurement of total and trabecular BMD was not influenced by weight, height or body mass index, but it was correlated with natural logarithm of years since menopause. We conclude that pQCT of the ultradistal radius is a precise method for measuring the true volumetric BMD and for detecting age-related bone loss in the trabecular and total bone of female subjects encompassing the adult age range and menopausal status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050972
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  • 5
    Electronic Resource
    Electronic Resource
    Phalangeal US velocity discriminates between normal and vertebrally fractured subjects (1999)
    Springer
    European radiology 9 (1999), S. 1632-1637 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Bone absorptiometry ; Bone densitometry ; Quantitative ultrasound ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to evaluate the diagnostic sensitivity of phalangeal bone ultrasound velocity of the hand in the diagnosis of osteoporosis and to compare this technique to bone mineral density (BMD) measurement at the lumbar spine assessed by dual X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). We investigated US velocity at the distal metaphysis of the proximal phalanx and spinal BMD in 101 women. Fifty-nine were healthy (mean age 50 ± 11.6 years) and 42 were osteoporotic (mean age 65 ± 6.6 years) with documented vertebral fractures. In the healthy population the relation with age was, respectively, r = –0.73 (p 〈 0.0001) for quantitative US (QUS), r = –0.74 (p 〈 0.0001) for QCT and r = –0.48 (p 〈 0.01) for DXA. Both US and DXA were correlated with QCT: r = 0.74 and r = 0.77 (p 〈 0.0001), respectively. Correlation of QUS and DXA was r = 0.56 (p 〈 0.0001). Phalangeal US velocity and spinal BMD (QCT and DXA) values discriminate healthy from osteoporotic women. Age-adjusted logistic regression analysis of the data showed standardized odds ratios (OR) for vertebral fracture to be similar for US and DXA (OR = 1.8 and 1.5, respectively) and stronger for QCT (OR = 2.9). Phalangeal US velocity reflects age-related bone loss and differentiates between healthy and osteoporotic subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050899
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