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  • 1
    Electronic Resource
    Electronic Resource
    Shortest nucleosomal repeat lengths during sea urchin development are found in two-cell embryos (1983)
    s.l. : American Chemical Society
    Biochemistry 22 (1983), S. 5626-5631 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00293a026
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  • 2
    Electronic Resource
    Electronic Resource
    A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of langerhans (1981)
    Springer
    Diabetologia 21 (1981), S. 470-475 
    Details
    ISSN: 1432-0428
    Keywords: Glucose ; B cell ; albino mouse ; membrane potential ; spike frequency ; insulin release ; islet perifusion ; islet of Langerhans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method has been developed for the simultaneous measurement of insulin release and electrical activity in single micro-dissected mouse islets of Langerhans. The effects of D-glucose have been studied in individual islets. Each islet was exposed to 0, 5.6, 11.1, 16.7, 22.2, 27.8 and 33.3 mmol/l glucose in a stepwise fashion. The minimum glucose concentration required to elicit spike activity is lower than that required to stimulate insulin release above basal levels and the maximum spike frequency occurs at a lower glucose concentration than does maximum insulin release. Following a reduction in glucose from 27.8 (or 33.3) to 5.6 mmol/l, membrane potentials returned to resting values within 2 min whereas insulin returned to basal values after 20 min. Increasing glucose from 5.6 to 27.8 mmol/l induced spike activity within 10 s; the insulin response was detected within 40 s. Thus, it is possible to use the single mouse islet for simultaneous measurements of insulin release and electrical activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257788
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  • 3
    Electronic Resource
    Electronic Resource
    A method of monitoring drugs for adverse reactions II. Amitriptyline and cardiac disease (1970)
    Springer
    European journal of clinical pharmacology 3 (1970), S. 51-55 
    Details
    ISSN: 1432-1041
    Keywords: Drug therapy ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A hospital based drug information system has been used to investigate a suspected association between unexpected death and the administration of the tricyclic antidepressant, amitriptyline in patients with a diagnosis of cardiac disease. The hospital information system made it possible to establish that 6 out of 53 such patients died suddenly and unexpectedly following the administration of the drug compared with no deaths in 53 control patients matched for age, sex, diagnosis and duration of stay. This high frequency of unexpected death was not found in patients without cardiac disease receiving amitriptyline nor in patients with cardiac disease receiving imipramine. It was observed that the cardiac patients receiving imipramine comprised a geriatric population occupying long stay beds whereas the amitriptyline patients occupied acute medical beds. It is concluded that amitriptyline should be used with caution in patients with cardiac disease. The importance of the accurate recording of medical information is stressed and the potentialities of hospital information systems are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00560292
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    “Extreme boiling” model for variable salinity of the Hokko low-sulfidation epithermal Au prospect, southwestern Hokkaido, Japan (1998)
    Springer
    Mineralium deposita 33 (1998), S. 568-578 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Hokko prospect is located in the Minamikayabe area southwestern Hokkaido, Japan, where gold-bearing quartz veins of Pliocene age are exposed at the surface. The alteration mineral assemblage is typical of low-sulfidation epithermal systems, with the quartz veins associated with adularia alteration overprinted on Late Miocene propylitic alteration. Fluid inclusion studies of the vein quartz reveal mean homogenization temperatures of approximately 220 °C, and the co-existence of low-salinity (〈2 wt.% NaCl equivalent) and moderate salinity (2 to 12 wt.% NaCl equivalent) fluid inclusions within the same veins. The moderate salinity fluid inclusions (2–12 wt.% NaCl equivalent) typically have relatively low homogenization temperatures between 150° to 200 °C. The results obtained from stable isotope analysis of  δ18O in quartz vein material showed a gradual decrease in  δ18O signatures with increasing depth. The majority of the samples have calculated fluid source signatures (δ18OH2O) between −8.0 and −10.0‰, but there is a significant change in the composition above 185 m drill depth. The shallower samples in particular show a wide range of oxygen isotope signatures that are associated with the moderate salinity fluid inclusions. We interpret that low-salinity inclusions within the Hokko system represent the composition of the liquid phase of the fluid, before boiling, and that the moderate-salinity inclusions are representative of the residual liquid phase, after extensive non-adiabatic boiling and vapor loss in an open system. This mechanism resulted in the entrapment of fluids with variable salinities at the same time, and in close proximity to each other. This is also reflected in the  δ18OH2O values which become more variable and heavier where the moderate-salinity inclusions occur. Deposition of ore minerals within the Hokko vein system also occurred at this time as a result of boiling and gas loss.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001260050173
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  • 5
    Electronic Resource
    Electronic Resource
    Intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia (1993)
    Springer
    Digestive diseases and sciences 38 (1993), S. 2247-2254 
    Details
    ISSN: 1573-2568
    Keywords: intragastric distribution ; gastric emptying ; functional dyspepsia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relative contributions of altered gastric motor function andHelicobacter pylori-associated active chronic gastritis to the pathogenesis of functional dyspepsia are controversial. We therefore evaluated scintigraphically the intragastric distribution and gastric emptying of a mixed solid-liquid meal in 75 patients with functional dyspepsia; patients were subdivided on the basis of both specific symptom clusters and the presence or absence ofH. pylori gastritis. Twenty-one (28%) patients displayed abnormal solid and/or liquid gastric emptying, with prolonged solid lag time the most prominent alteration detected. The number of patients with abnormal scintigraphic patterns increased to 36 (48%) when intragastric distribution parameters (fundal half-emptying time and antral maximal fraction) were examined. Although patients with reflux-like dyspepsia (N=36) demonstrated significantly slower rates of liquid emptying at 45 and 70 min and a higher prevalence of abnormal liquid intragastric distribution when compared to patients with motility-like dyspepsia (N=39) or to controls (N-34), the absolute differences were small and unlikely to be of clinical significance. Patients withoutH. pylori gastritis (N=50) demonstrated a significantly more prolonged solid lag time when compared to those withH. pylori gastritis (N=25), but the difference was small and there were no other differences between these two subgroups. We conclude that in patients with functional dyspepsia: (1) abnormal solid gastric emptying is present in less than one third; (2) assessment of parameters of intragastric distribution enables more subtle gastric motor dysfunction to be identified; and (3) neither dividing patients into symptom subgroups nor accounting for the presence or absence ofH. pylori gastritis has a major influence on the prevalence or type of gastric motor dysfunction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01299904
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  • 6
    Electronic Resource
    Electronic Resource
    Cigarette smoking and nicotine delay postprandial mouth-cecum transit time (1992)
    Springer
    Digestive diseases and sciences 37 (1992), S. 1544-1547 
    Details
    ISSN: 1573-2568
    Keywords: cigarette smoking ; nicotine ; mouth-cecum transit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The acute effects of both cigarette smoking and nicotine on postprandial mouth-cecum transit were studied in 20 habitual smokers, 10 males and 10 females. Mouth-cecum transit time was measured by the breath hydrogen technique, following ingestion of a standard mixed liquid meal. Each subject was studied on four separate occasions, either (1) sham or actively smoking two standard cigarettes, commencing 20 min after the meal, or (2) chewing two placebo or nicotine tablets over a 60-min period, commencing immediately after the meal. The time of administration of these stimuli was designed to minimize the effects on mouth-cecum transit time of alterations in gastric emptying. Mouth-cecum transit time was prolonged in response to both smoking [median and interquartile range: 120 (95, 150) min vs 100 (75, 140) min,P=0.01] and nicotine [120 (80, 170) min vs 100 (70, 140) min,P=0.002]. No difference was observed between sexes with respect to nicotine; the effect of smoking on mouth-cecum transit time, however, was less pronounced in females compared to males [difference active-placebo: 10 (10, 20) min vs 35 (20, 60) min,P=0.01]. We conclude that acute cigarette smoking delays mouth-cecum transit time, an effect most likely due to nicotine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296500
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