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  • 1
    Electronic Resource
    Electronic Resource
    Development of immunoreactive atrial natriuretic peptide in fetal hearts of spontaneously hypertensive and Wistar-Kyoto rats (1988)
    Springer
    Anatomy and embryology 178 (1988), S. 359-363 
    Details
    ISSN: 1432-0568
    Keywords: Atrial natriuretic peptide ; Fetal heart ; Spontaneously hypertensive rat ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The development of immunoreactive atrial natriuretic peptide (ANP) was studied in fetal hearts of spontaneously hypertensive (SHR) and compared to normotensive Wistar-Kyoto (WKY) rats. While SHR fetal hearts were noticeably less developed than those of WKY at 10 and 11 days gestation, both strains showed ANP immunoreactive cells in some but not all primitive heart tubes. At 12 days additional ANP immunoreactive cells appeared in formative trabeculae of the ventricle and atrium. ANP cells were also observed in the myogenic layer of the truncus and bulbus arteriosus and their derivatives from 11 through 16 days, but not at 18 days. In both strains, there were more ANP cells in the left ventricle than in right beginning at day 13. There were no obvious strain differences in the developmental pattern and timing of ANP producing cells. However, on the day of birth, staining was reduced in hearts from some WKY newborn pups compared with hearts from SHR newborns and ventricular staining was reduced in both strains when compared to fetal hearts. These observations indicate that ANP is one of the earliest peptide hormones produced and that the predisposition to genetic hypertension does not appear to influence the development of ANP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00698667
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  • 2
    Electronic Resource
    Electronic Resource
    Scanning electron microscopy of the decidual stalk and decidua basalis in the mouse (1981)
    Springer
    Anatomy and embryology 162 (1981), S. 435-441 
    Details
    ISSN: 1432-0568
    Keywords: Decidual stalk ; Decidua basalis ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Placentas either in situ or mechanically separated from their uterine beds were surveyed by scanning electron microscopy to determine the changing relationship of the placenta to its uterine bed with special reference to alteration in the decidua basalis accompanying parturition. At 13 days gestation the placenta is connected to the uterus by a short, broad decidual stalk which becomes longer and more constricted by term. The stalk is covered by a layer of squamous epithelium. Mechanical separation of the placenta and uterus in early gestation reveals that the entire decidua basalis of the decidual stalk is composed of large coarse fibers. As gestation progresses, a relatively smooth acellular capsule forms around the base of the placenta. However, the center of the decidua basalis, the core of the stalk, continues to be composed of large coarse fibers throughout gestation and appears to be the only region penetrated by maternal vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00301869
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Umbilical vessels of spontaneously hypertensive rats (1984)
    Springer
    Anatomy and embryology 170 (1984), S. 289-294 
    Details
    ISSN: 1432-0568
    Keywords: Umbilical vessels ; Endothelium ; Spontaneously hypertensive rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Umbilical vessels of spontaneously hypertensive rats, control strain Wistar-Kyoto rats and rats treated with α-methyldopa were compared using the scanning electron microscope and light microscope. Observations with the scanning electron microscope revealed that the venous endothelial cells were relatively flat, giving the luminal surface of the vein a smooth appearance. The nuclear region of the fusiform arterial endothelial cells was responsible for the bumpy appearance of the luminal surface of the artery. Microvilli were a consistent feature of the endothelium in both umbilical vessels. There was no consistant pattern of distribution or density of microvilli within either vessel, but microvilli were more abundant on the luminal surface of the artery than in the vein. The luminal surface of some endothelial cells of the artery had long straight processes which crossed several cells before terminating. Light microscopic observations revealed that the endothelial cells and cells of the tunica intima and media contained an abundance of glycogen. The same layers stained sparsely for acid glycosaminoglycans. Maternal hypertension and treatment of spontaneously hypertensive rats with the antihypertensive drug, α-methyldopa, did not result in significant morphological alterations of either the endothelium or tunica media of the umbilical blood vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318732
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  • 4
    Electronic Resource
    Electronic Resource
    Localization of 125I-atrial natriuretic peptide (ANP) in the rat fetus (1991)
    Springer
    Anatomy and embryology 183 (1991), S. 245-249 
    Details
    ISSN: 1432-0568
    Keywords: ANP ; Receptors ; Fetal rat ; Spinal cord ; Neural crest ; Lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this in vitro autoradiographic study of ANP-binding sites in fetal rats, 125I-ANP bound to receptors in certain developing neural crest derivatives, including the boundary caps, dorsal root ganglia, and Schwann cells of peripheral nerves. Within the spinal cord, ANP receptors were localized in the roof plate and floor plate. The developing meningeal layer of the CNS, blood vessels, lung, liver, and wall of the herniated gut were also labeled. The topographical and temporal correlation of the appearance of ANP receptors with the developmental processes of the targets suggests that ANP in the fetus is multifunctional, and may be involved in diverse events such as gliogenesis, formation of axonal pathways or surfactant production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00192212
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  • 5
    Electronic Resource
    Electronic Resource
    Scanning electron microscopy of fused mouse placentas and associated uterine bed (1980)
    Springer
    Cell & tissue research 210 (1980), S. 349-351 
    Details
    ISSN: 1432-0878
    Keywords: Fused placentas ; Uterine bed ; Scanning electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The decidual surface of two fused placentas and the associated uterine bed were examined by scanning electron microscopy. The compact decidua basalis fits into a uterine depression filled with coarse fibers which is surrounded by a smooth area that gradually becomes folded. Placental fusion due to twinning or crowding is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237622
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  • 6
    Electronic Resource
    Electronic Resource
    Atrial natriuretic peptide binding in rat placenta, yolk sac, decidua, and materal placental vessels (1993)
    Springer
    Cell & tissue research 272 (1993), S. 391-394 
    Details
    ISSN: 1432-0878
    Keywords: ANP binding ; Yolk sac ; Decidua ; Maternal placental vessels ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Using in vitro autoradiography, binding sites of 125I-ANP (atrial natriuretic peptide) were localized in the rat placenta, visceral yolk sac, and decidua at 16, 18, and 20 days of gestation. There was diffuse binding over the labyrinthine region of the placenta and an intense binding over the decidual gland and visceral yolk sac. In the yolk sac, ANP localized over the cores of the villi where it may be involved with the regulation of transport across the membranes or the flow of blood through the vitelline vessels. Of particular interest was binding over the maternal blood vessels supplying the decidual region and placenta. Receptors were located on the endothelial cells and smooth muscle cells of the arteries and veins, indicating that ANP may be involved with regional regulation of blood flow to the placenta.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00302744
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  • 7
    Electronic Resource
    Electronic Resource
    Bone morphology of weanling rats from dams subjected to fluoride (1983)
    Springer
    Cell & tissue research 233 (1983), S. 689-691 
    Details
    ISSN: 1432-0878
    Keywords: Fluoride ; Progeny ; Bone ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Femurs of weanling rats from third-pregnancy litters of dams given 150 ppm fluoride in the drinking water were examined by light- and scanning-electron microscopy. Under the conditions of the experimental procedure, no pathological changes were seen in the femurs as a result of maternal ingestion of fluoride. These results indicate that the amount of fluoride crossing the placenta and mammary gland was insufficient to produce significant morphological changes in the bones of 3-week-old rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212235
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  • 8
    Electronic Resource
    Electronic Resource
    Immunohistochemical localization of atrial natriuretic peptide in the developing and adult mammalian kidney (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 190 (1991), S. 182-191 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The discovery, within the last decade, of atrial natriuretic peptide (ANP), a family of peptides with natriuretic/diuretic and vasorelaxant properties, has prompted much research into the mechanisms and sites of action of ANP within the kidney. In the present study, ANP was localized in the kidneys of several mammalian species by immunohistochemical techniques (1) to identify possible sites of synthesis; (2) to compare the localization of ANP to known physiological effects; (3) to determine species differences, if any, in ANP localization; and (4) to study the development of ANP immunoreactivity in the fetal and neonatal rat kidney. Using an antibody against rat ANP IV, ANP was localized exclusively on the proximal convoluted tubule (PCT) brush border and within intercalated cells of the outer medullary and cortical collecting tubules and ducts of adult mouse, rat, pig, monkey, and human kidneys. The development of ANP immunoreactivity paralleled the differentiation and maturation of collecting duct epithelium in rat fetal kidney. Atrial natriuretic peptide found within intercalated cells of the cortical and outer medullary collecting ducts may be the result of endogenous synthesis and, following secretion, may be available to receptors in the inner medullary collecting ducts.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001900207
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