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  • 1
    Electronic Resource
    Electronic Resource
    Structural requirements for neuropeptide Y18-36-evoked hypotension: a systematic study (1992)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 35 (1992), S. 2836-2843 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00093a017
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis and hypertensive activity of neuropeptide Y fragments and analogs with modified N- or C-termini or D-substitutions (1989)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 32 (1989), S. 597-601 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00123a014
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of lateral sphincterotomy on internal anal sphincter function (1995)
    Springer
    Diseases of the colon & rectum 38 (1995), S. 700-704 
    Details
    ISSN: 1530-0358
    Keywords: Chronic anal fissure ; Lateral sphincterotomy ; Internal anal sphincter ; Manometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This study was designed to investigate the effect of lateral sphincterotomy on internal anal sphincter function in patients with chronic anal fssure. METHODS: Using an eight-channel perfusion catheter and computerized data analysis, a prospective manometric study was performed on patients with chronic anal fissure undergoing lateral sphincterotomy (LS). RESULTS: Mean resting pressure (MRP) in patients with anal fissure (85.1 mmHg) was significantly higher (P=0.012) than control subjects (63.3 mmHg). One week following LS there was a significant reduction in MRP (50.0 mmHg;P=0.0014), and this was maintained when reassessed five weeks later (MRP=56.4 mmHg;P=0.0019). There was no significant difference in coefficent of variation (a measure of the degree of manometric asymmetry of the anal canal) in the control group (mean, 8.9 percent) and in patients with anal fissure (mean, 7.7 percent;P=0.43). LS created a significant increase in anal canal resting manometric asymmetry when assessed at one (mean, 17.3 percent;P=0.0013) and six weeks (mean, 11.7 percent;P=0.027) after the procedure. CONCLUSION: LS produces a global and symmetric decrease in anal canal resting pressure. In addition, it produces a significant increase in manometric asymmetry of the resting anal canal by creating a detectable segmental defect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02048025
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Anastomotic configuration does not affect recurrence of Crohn's disease after ileocolonic resection (1995)
    Springer
    International journal of colorectal disease 10 (1995), S. 67-69 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'influence de la configuration d'une anastomose sur la récidive des symptômes de la maladie a été analysée dans une étude séquentielle de patients soumis à une résection iléale pour maladie de Crohn. De 1972 à 1991, 92 patients ont subi 102 anastomoses iléo-coliques après résection d'un segment intestinal pour maladie de Crohn. La configuration de l'anastomose iléo-clique a été termino-latérale (ES, n=68) ou latéro-latérale (SS, n=34). La majorité des patients dans les deux groupes était de sexe féminin et les deux groupes étaient similaires quant à la durée de l'évolution clinique de la maladie avant la résection, la corticothérapie, le nombre de résections intestinales réalisées par le passé, l'indication pour la chirurgie et la longueur du segment iléal réséqué. Aucune fuite anastomotique n'est survenue dans chacun des deux groupes. Trente-neuf patients ont développé une nouvelle poussée de la maladie de Crohn, soit 31 (46%) dans le groupe ES et 8 (24%) dans le groupe SS. Cette différence peut être mise en relation avec la durée du follow-up. Le taux annuel de récidives symptômatiques était identique dans les deux groupes ES (0,066) et SS (0,052).
    Notes: Abstract The influence of anastomotic configuration on recurrence of symptomatic Crohn's disease has been assessed in a sequential study of patients undergoing resection of ileal Crohn's disease. Between 1972 and 1991 92 patients had 102 ileocolonic anastomoses constructed after resection of intestinal Crohn's disease. The configuration of the ileocolonic anastomosis was either end to side (ES, n=68) or side to side (SS, n=34). The majority of patients in both groups were female and both groups were similar for duration of Crohn's disease at resection, steroid therapy, previous number of intestinal resections, indication for surgery and length of ileum resected at operation. No anastomotic leak occurred in either group. A total of 39 patients developed symptomatic recurrent Crohn's disease including 31 (46%) in the ES group and 8 (24%) in the SS group. This difference was related to the length of follow-up, the annual rate of symptomatic recurrence was almost identical for both end to side (0.066) and side to side (0.052) anastomoses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00341197
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  • 5
    Electronic Resource
    Electronic Resource
    Postoperative intra-abdominal and pelvic sepsis complicating ileal pouch-anal anastomosis (1988)
    Springer
    International journal of colorectal disease 3 (1988), S. 149-152 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a series of 500 patients who underwent ileal pouch-anal anastomosis for ulcerative colitis or polyposis coli, significant intra-abdominal or pelvic sepsis developed in 30 (6%). Among the patients who did not require laparotomy because they responded to treatment with antibiotics or local drainage (surgical or radiologically guided) or both, no pouches were excised and the ileostomy closure rate (92%) was similar to that for the patients who did not have sepsis. The 17 patients whose sepsis did require laparotomy had a high rate of pouch excision (41%) (p〈0.0001) and a low rate of ileostomy closure (29%) (p〈0.0001). Factors identified as possibly associated with severe sepsis included female gender and ulcerative colitis complicated by toxicity or malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01648357
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    Paper (German National Licenses)
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