ISSN:
1573-4927
Keywords:
methylglyoxal
;
methylglyoxal dehydrogenase loci 1, 2, 3
;
Mgd1 polymorphism
;
heart-specificMgd3 expression
;
glyoxalase I
;
rat chromosome 13
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract A genetic locus controlling the electrophoretic mobility of a methylglyoxal dehydrogenase (EC 1.2.1.23) in the rat is described. The locus, designatedMgd1, is expressed in liver and kidney. Inbred rat strains have fixed either alleleMgd1 a or alleleMgd1 b . Codominant expression is observed in heterozygotes, providing evidence for a tetrameric enzyme structure. Backcross progenies showed the expected 1:1 segregation ratio, and there is evidence thatMgd1 is linked toPep3 andFh1 on chromosome 13. There is also evidence for two additional methylglyoxal dehydrogenases:Mgd2, present in liver and kidney, andMgd3, present only in heart.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00554618
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