ISSN:
0138-4988
Keywords:
Life Sciences
;
Life Sciences (general)
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Process Engineering, Biotechnology, Nutrition Technology
Notes:
The morphology of filamentous microorganisms does essentially affect the production of metabolites. Agitating conditions may affect the morphology and for this reason the production of metabolites too.The following parameters it was found to have an influence: Reynolds mixing numberimpeller blade tips velocitymean shear stress close to the impellerimpeller power consumption per unit volumecavitation pressure dropIt were presumed three mechanisms for the mechanical effect on the microorganisms: 1the direct impact of the impeller blades on the microorganisms-collision2the shear stress in the liquid phase3a sharp pressure decrease behind the impeller blades-cavitationMathematical relationships are developed for the different mechanisms.Using Aspergillus niger it is shown what morphological and physiological states of this microorganism are caused by mechanical straining and the conditions for the maximal production of citric acid are studied.Requirements for scale-up are discussed.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/abio.370010404
Permalink