ISSN:
0887-624X
Keywords:
biodegradability
;
oligo[(glycolic acid)-alt-(L-cysteine)]
;
poly[(lactic acid)-depsipeptide]
;
ring-opening polymerization
;
pendant thiol group
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
To obtain water-soluble oligodepsipeptide with pendant thiol groups, the alternating co-oligomer [oligo(Glc-alt-Cys)], consisting of glycolic acid (Glc) and L-cysteine (Cys) residues as α-hydroxy acid and α-amino acid residues, respectively, was prepared by means of ring-opening homo-oligomerization of cyclo[Glc-Cys(MBzl)] and subsequent deprotection of methoxybenzyl groups. Moreover, to modify the properties of poly(lactic acid) [poly(LA)] and to introduce pendant thiol groups to poly(LA), the terpolymer of LA, Glc, and Cys {poly[LA-(Glc-Cys)]} was synthesized through ring-opening and copolymerization of L-lactide with the protected cyclodepsipeptide, cyclo[Glc-Cys(MBzl)] and subsequent deprotection of methoxybenzyl groups. By changing the mol fraction of (Glc-Cys) unit, the solubility, thermal transition, degradation behavior of the modified poly(LA), and the water contact angle of its film could be varied. © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 1283-1290, 1998
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
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