ISSN:
1435-5922
Keywords:
Key words: liver, regeneration, Fas, Fas ligand, partial hepatectomy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract: The interaction of Fas (APO-1/CD95) and the Fas ligand system induces apoptosis. However, the role of the Fas/Fas ligand system in normal physiological liver cell death remains to be determined. Using northern blotting analysis, we investigated the role of Fas and Fas ligand mRNA expression in liver regeneration in rats until 14 days after partial hepatectomy. Partial hepatectomy led to a significant decrease in Fas mRNA levels at 2 h, with a further gradual reduction until 18 h. The minimum Fas mRNA levels persisted until 5 days after the surgery. Fas mRNA levels then increased markedly at 6 days, and gradually increased to the initial levels by 14 days after the surgery. However, partial hepatectomy did not affect the expression of Fas ligand mRNA levels. These findings suggest that Fas mRNA is down-regulated in liver regeneration after partial hepatectomy, and that when the original liver mass is gradually regenerating, Fas mRNA is again up-regulated to the initial levels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/PL00009973
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