ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

An Analysis of γ-Aminobutyrate Receptors and Uptake by Isolated Purkinje Cells (1980)

Henn, Fritz A. ; Venema, Rick ; Anderson, David ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 34 (1980), S. 0

add to mindlist on the mindlist

Details

ISSN: 1471-4159

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract: An isolated fraction of Purkinje perikarya was prepared. This fraction had [3H]GABA receptor binding and [3H]muscimol binding analogous to that reported for heterogeneous cerebellar membranes. The finding of two binding components with each ligand suggests that these components do not represent two binding sites, one presynaptic and the other postsynaptic, since both are clearly seen on purified Purkinje cell bodies. Subcellular fractionation indicates that synaptic endings and plasma membranes are enriched in GABA receptors compared with intracellular organelles. Purkinje cell bodies were also found to possess a high-affinity transport system for GABA, which was sensitive to inhibition by diaminobutyric acid (DABA) but not by β-alanine. They showed no evidence of homoexchange (the movement of label without net transport). This supports our suggestion that homoexchange is an artifact of synaptic particle formation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-4159.1980.tb11259.x

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Functional assessment of GABA uptake or exchange by synaptosomal fractions (1976)

SELLSTROM, ÅKE ; VENEMA, RICK ; HENN, FRITZ

[s.l.] : Nature Publishing Group

Nature 264 (1976), S. 652-653

add to mindlist on the mindlist

Details

ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Table 1 Changes in the external [GABA] on incubation of synaptosomes in various concentrations of GABA for 20 min (GABA) (GABA) * Before Incubation After 20 min Incubation in media (M) in media 10?5 M in synaptosomes 105M 103 7.0 + 0.3 111+34 io-4 5.6+0.7 51 I 17 I0-r〉 ...