ISSN:
1432-1203
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract A genomic clone encoding prothymosin α (gene symbol: PTMA), a nuclear-targeted protein associated with cell proliferation, was isolated and the 5′-regulatory region subcloned and sequenced. Because of previously reported discrepancies between several cDNA clones and a genomic clone for prothymosin α, we determined the sequence of the first exon and of a 1.7-kb region 5′ to the first exon. The sequence of the genomic clone reported here corresponds to the published cDNA sequences, suggesting that the previously noted discrepancies may be due to genetic polymorphism in this region. In addition, our sequence data extend the known 5′-upstream sequence by an additional 1.5 kb allowing the identification of numerous, potential cis-acting regulatory sites. This 5′-flanking cloned probe permitted us to localize the protothymosin gene to chromosome 2 in humans.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00202480
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