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  • 1
    Electronic Resource
    Electronic Resource
    Variations in dried blood spot immunoreactive trypsin in relation to gestational age and during the first week of life (1986)
    Springer
    European journal of pediatrics 144 (1986), S. 547-549 
    Details
    ISSN: 1432-1076
    Keywords: Immunoreactive trypsin ; Premature newborns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dry blood spot immunoreactive trypsin was measured by radioimmunoassay in 84 preterm babies and in 65 full-term newborns studied daily from the first to the fifth day of life. In a control group of 3858 full-term newborns, trypsin concentrations at days 4–6 of life exhibited a log-normal pattern distribution, the geometric mean being 18 ng/ml serum. Immunoreactive trypsin concentrations did not change significantly between days 1, 2, 3, 4 and 5 after birth. Immunoreactive trypsin was found to be significantly lower (geometric mean 9 ng/ml, P〈0.01) in preterm newborns before 32 weeks of gestation. In hypotrophic newborns of 34 weeks gestational age, immunoreactive trypsin values were higher than those observed at 31 weeks of gestation in eutrophic newborns, the mean birth weight not being different between both groups. These data suggest that trypsin production by the pancreas is dependent on maturity but does not seem related to intrauterine nutritional status. Immunoreactive trypsin concentrations do not change after 32 weeks gestational age and during the first postnatal week.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496032
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Proximal phocomelia and radial ray aplasia in fetal valproic syndrome (1990)
    Springer
    European journal of pediatrics 149 (1990), S. 266-267 
    Details
    ISSN: 1432-1076
    Keywords: Embryopathy ; Fetal valproic syndrome ; Phocomelia ; Teratogen ; Valproic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a child with multiple congenital anomalies born to a women treated with valproic acid (1000 mg/day) for post traumatic epilepsy. Defects included the typical dysmorphism of the “fetal valproic syndrome”, bilateral radial ray aplasia, unilateral proximal phocomelia of the upper limb, kidney hypoplasia and brain atrophy. A direct teratogenic effect of valproic acid is suspected on an experimental basis, and validated by two previous reports of radial defects after valproic acid exposure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02106290
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Mortality in 504 infants weighing less than 1501 g at birth and treated in four neonatal intensive care units of South-Belgium between 1976 and 1980 (1985)
    Springer
    European journal of pediatrics 144 (1985), S. 219-224 
    Details
    ISSN: 1432-1076
    Keywords: Very low birth weight ; Mortality ; Epidemiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mortality was studied in 504 infants weighing less than 1501 g at birth and treated in four neonatal intensive care units of South-Belgium between 1976 and 1980. Two hundred and twenty-one babies died during their stay at the hospital, a mortality rate of 438 per 1000 live births. The neonatal mortality rate (mortality during the first 28 days of life) was 373 per 1000 live-births. Thirty-three infants died after the neonatal period, which is 15% of the total number of deaths. Twothirds of these post-neonatal deaths were related to complications of diseases associated with pre-term delivery. Mortality rates were higher in infants of less than 1001 g than in those of 1001–1250 g or 1251–1500 birth weight. In each birth weight category, patients born in their own obstetrical departments and referred infants had similar mortality rates. Longitudinal analysis showed improving mortality rates between 1976 and 1977 in the total population of VLBW infants, between 1977 and 1978 in infants of 〈1001 g and in 1980 compared to 1976 in the 1251–1500 g group. There were higher incidences of need for ventilatory assistance, patent ductus arteriosus, necrotising enterocolitis and septicaemia in referred patients of 〈1001 g than in patients born in their own obstetrical departments with comparable birth weight. Artification ventilation was more often required in referred infants of 1251–1500 g. This study confirms the importance of considering at least the complete hospital stay when analysing mortality in VLBW infants. Infants of 〈1001 g had high mortality, particularly after the neonatal period. This phenomenon was asscciated with complications of morbid conditions related to extreme prematurity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451944
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    Paper (German National Licenses)
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