ISSN:
1573-8221
Keywords:
17β- and 17α-estradiosl
;
neurotoxin AF64A
;
active avoidance
;
rats
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract It was shown for the first time that estrogens 17β- and 17α-estradiols compensate impaired cognitive functions in rats with partial chronic deprivation of cholinergic functions in the central nervous system induced by intracerebral administration of selective cholinergic neurotoxin AF64A. 17β-Estradiol produced strong dose-dependent changes in the weights of hormone-sensitive endocrine glands, while 17α-estradiol did not affect the weight of the gonads and slightly influenced (in high concentration) the weights of the adrenal glands and thymus. The positive effects of exogenous 17β- and 17α-estradiols on cognitive functions are due to their antioxidant properties, rather than due to specific action on hormone-sensitive endocrine glands.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02439796
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