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Electron currents generated by the human phagocyte NADPH oxidase (1998)

Schrenzel, Jacques ; Serrander, Lena ; Bánfi, Botond ; [et al.]

[s.l.] : Macmillan Magazines Ltd.

Nature 392 (1998), S. 734-737

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Electron transport across biological membranes is a well-known feature of bacteria, mitochondria and chloroplasts, where it provides motive forces for vectorial transport processes. In contrast, electron transport is generally not found in the plasma membrane of eukaryotic cells, possibly ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/33725

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Activation of phospholipase D is an early event in integrin-mediated signalling leading to phagocytosis in human neutrophils (1996)

Serrander, Lena ; Fällman, Maria ; Stendahl, Olle

Springer

Inflammation 20 (1996), S. 439-450

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ISSN: 1573-2576

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Integrin receptors on human neutrophils mediate adhesion and phagocytosis. These functions are linked to a signal-transduction cascade that rearranges the cytoskeleton. The intention of this study was to clarify how activation of phospholipase D (PLD) is coupled to the complement receptor three (CR3, CD18/CD11b)mediated ingestion process. Carbobenzyloxy-leucine-tyrosine-chloromethylketone (zLYCK) inhibited PLD activation induced by complement-opsonized yeast particles (COYP) by 39%. Phagocytosis of these particles was reduced by zLYCK to the same extent. Anti-CD18-antibodies bound to protein A-positiveStaphylococcus aureus bacteria induced a significant PLD activation. These particles were not ingested which implicates that CR-mediated ingestion per se is not required to induce PLD activity. Cytochalasin B-treatment, which blocks actin reorganization, partly reduced COYP-mediated PLD activity, but had no effect on activity caused by anti-CD 18-coated particles. This excludes activation of PLD to be a secondary event, but rather an early signal in the phagocytic uptake prior to actin reorganization. These data suggest an important and early role for PLD in integrin-mediated phagocytosis.