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Sur l'action cytonarcotique des sels de nickel chez Paramecium caudatum Ehrb. (1963)

PUYTORAC, P. ; ANDRIVON, C. ; SERRE, F.

Oxford, UK : Blackwell Publishing Ltd

The @journal of eukaryotic microbiology 10 (1963), S. 0

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ISSN: 1550-7408

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology

Notes: SYNOPSIS. Cytonarcotic action of Ni-chloride Ni-sulfate and Ni-nitrate is studied with mating types C and D French variety II of P. caudatum= XV and XVI American variety 8. The time which is necessary to make the ciliates motionless is proportional to Ni ion number in solution, but, in any case, there is a minimum time for narcosis. Mating types have very different sensitivity. C is more sensitive than D. Ba++ and Ca++ strongly antagonize the action of Ni++. This antagonism, only biological, depends on the simultaneous presence of the ions in solution and has maximum value when the ions are in definite and constant proportion. Formation of digestive vacuoles involves reactions which make the ciliate resistant to Ni probably by decrease of membrane permeability. After narcosis, about twenty generations must pass before the rate of multiplication is again normal.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1550-7408.1963.tb01634.x

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Effects of acute administration of cyclazocine on the metabolism of biogenic amines in different regions of rat brain (1981)

Gavend, M. M. ; Serre, F. ; Gavend, M. R. ; [et al.]

Springer

Psychopharmacology 75 (1981), S. 79-83

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ISSN: 1432-2072

Keywords: Cyclazocine ; Acute treatment ; Dopamine ; Noradrenaline ; Serotonin ; Monoamine metabolites ; Brain regional assay ; Rat

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract The effects of cyclazocine on the metabolism of dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (5-HT) in regions of rat brain were studied by measuring changes in the levels of the monoamines and their major metabolites. Doses ranging from 4–32 mg/kg were tested. Rats were sacrificed 1 or 2 h after administration of the drug, according to the experiment. Administration of cyclazocine significantly decreased DA concentration and increased the levels of DOPAC and HVA in striatum. Cyclazocine decreased the levels of NA, and markedly increased the levels of MHPG-SO4 and 5-HIAA in cortex, hypothalamus, midbrain and pons-medulla, while little change in 5-HT concentration, except a decrease after the highest dose, was observed. These changes in the metabolism of the monoamines differed in their amplitude and temporal nature. The possible roles of dopaminergic, noradrenergic and serotoninergic neurons in different brain regions are discussed in relation to modifications of locomotor activity and the induction of bizarre behavior resulting from cyclazocine administration in rats. These investigations may add to the understanding of the mechanism of psychotomimetic effects produced in man by this drug.