ISSN:
1573-904X
Keywords:
intestinal transport
;
sulfanilic acid
;
hapten
;
immunization
;
protein-hapten conjugate
;
everted sac
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Intestinal transport of sulfanilic acid was examined by means of an in vitro everted sac technique in rats immunized with a bovine γ-globulin–sulfanilic acid conjugate. At a low concentration of sulfanilic acid, the intestinal transport of sulfanilic acid was decreased in rats immunized with bovine γ-globulin–sulfanilic acid conjugate. This phenomenon was dose dependent and antigen specific, since there was no difference in the transport of sulfanilic acid at a high concentration and of an unrelated hapten. These results suggested that parenteral immunization impaired not only the intestinal transport of macromolecular antigens, as previously shown, but also the transport of the low molecular weight hapten, sulfanilic acid.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015832009217
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