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  • 1
    Electronic Resource
    Electronic Resource
    Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction (1999)
    [s.l.] : Nature America Inc.
    Nature biotechnology 17 (1999), S. 265-270 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Several nonmammalian members of the RNase A superfamily exhibit anticancer activity that appears to correlate with resistance to the cytosolic ribonuclease inhibitor (RI). We mutated two human ribonucle- ases—pancreatic RNase (hRNAse) and eosinophil-derived neurotoxin (EDN)—to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/7010
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  • 2
    Electronic Resource
    Electronic Resource
    Reply to 'Encephalitis outbreak finds Indian officials unprepared' (2006)
    [s.l.] : Nature Publishing Group
    Nature medicine 12 (2006), S. 269-270 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] To the editor: We have found that the Japanese encephalitis outbreak in India, described in a recent news article by T.V. Padma, is overblown, leading to erroneous diagnosis of many encephalitis cases. Media reports have attributed the outbreak primarily to Japanese encephalitis, but that is ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0306-269b
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  • 3
    Electronic Resource
    Electronic Resource
    Elasto-plastic finite element analysis of a crack in an infinite plate (2000)
    Springer
    International journal of fracture 103 (2000), S. 163-176 
    Details
    ISSN: 1573-2673
    Keywords: Finite element method ; plasticity ; fracture ; unbounded media
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The elastic support method was recently developed to simulate the effects of unbounded solids in the finite element analysis of stresses and displacements. The method eliminates all the computational disadvantages encountered in the use of `infinite' elements or coupled finite element boundary element methods while retaining all the computational advantages of the finite element method. In this paper, the method is extended to the elasto-plastic analysis of fracture in infinite solids by using the load increment approach and including the effects of strain hardening. Numerical tests and parametric study are conducted by analysing a straight crack in an infinite plate. Present results for J integrals and plastified zones are compared, respectively, with analytical solutions and available results obtained by using the body force method. The agreement between the results is found to be very good even if the truncation boundary of the finite element model is located very close to the crack tip or the plastified zone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007698426810
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis and characterisation of binuclear oxo molybdenum(V) hypophosphite (1989)
    Springer
    Transition metal chemistry 14 (1989), S. 248-250 
    Details
    ISSN: 1572-901X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A binuclear oxo MoV hypophosphite of composition [Mo2O4(H2PO2)2(H2O)2], is prepared by direct reduction of MoVI oxide hydrate (MoO3·H2O) with hypophosphorus acid in an argon atmosphere, and characterised by i.r., and electronic spectra, magnetic susceptibility and cyclic voltammetry measurements.1H and31Pn.m.r., x-ray diffraction and thermal analysis data contribute to its molecular structure elucidation, and a dioxobridged dioxo MoV with bidentate hypophosphite ion and water molecule completing the octahedral coordination around each Mo atom is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01098221
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  • 5
    Electronic Resource
    Electronic Resource
    Physico-chemical studies on the chelation behaviour of acenaphthenequinone monothiosemicarbazone (AQTS) with some bivalent metal ions (1984)
    Springer
    Transition metal chemistry 9 (1984), S. 473-476 
    Details
    ISSN: 1572-901X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The stability constants of the chelates formed from acenaphthenequinone monothiosemicarbazone and magnesium(II), manganese(II), cobalt(II), nickel(II), copper(II), zinc(II) or cadmium(II) have been determined pH-metrically in 75% v/v aqueous dioxan at various ionic strengths of NaClO4 and at different temperatures. The method of Bjerrum and Calvin(1, 2) as modified by Irving and Rossotti(3), has been used to determine the ñ and pL values. The stability constants were calculated on an IBM 360 FORTRAN-IV computer patterned after that of Sullivanet al. (4) to give βn values using a weighted least squares method. The Smin, values were also calculated. The thermodynamic stability constant has been determined by extrapolating the log K1 vs √μ plot at zero ionic strength. The other thermodynamic functions have been calculated from the stability constants obtained for different temperatures at constant ionic strength. The bivalent metal stability sequence of AQTS chelates is in agreement with reported metal orders for other chelating reagents. The order of free energies and enthalpies of chelate formation for AQTS are: Mn2+〈Co2+〈Ni2+〈Cu2+〉Zn2+.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00620681
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  • 6
    Electronic Resource
    Electronic Resource
    Finite element analysis of unbounded and incompressible fluid domains (1985)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 21 (1985), S. 1659-1669 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A finite element technique of analysing the hydrodynamic pressure, resulting from the vibration of a structure submerged in an unbounded fluid domain, is presented. A suitable boundary condition is proposed for the surface where the unbounded fluid domain is truncated. Pressure is assumed to be the nodal unknown and the fluid is treated as being incompressible and inviscid. The proposed method is computationally very efficient and its implementation in a finite element program is quite straightforward. The efficiency of the method is demonstrated by analysing some two-dimensional problems.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620210908
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  • 7
    Electronic Resource
    Electronic Resource
    Modelling of radiation damping in fluids by finite elements (1986)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 23 (1986), S. 945-957 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A very efficient technique is presented to model the effects of radiation damping in the computation of added mass for the dynamic analysis of submerged structures. The structure is assumed to be surrounded by an infinite, incompressible and inviscid fluid field and the effect of the free surface is neglected. The technique is implemented in the finite element analysis of two-dimensional problems, assuming pressure to be the nodal unknown. The implementation procedure is quite simple and the symmetrical and banded form of the matrix of coefficients remains unchanged. With the use of the proposed radiation condition, the fluid field may be truncated at a relatively very short distance from the solid - fluid interface. This results in great computational advantages. Furthermore, a guideline is suggested for the selection of the geometry and the location of the truncation boundary to enhance the computational efficiency. The effectiveness and efficiency of the technique is demonstrated by analysing several cases for different geometries of the solid - fluid interface and the truncation boundary.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620230514
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  • 8
    Electronic Resource
    Electronic Resource
    Evaluation of recent scientific research output by a bibliometric method (1992)
    Springer
    Scientometrics 23 (1992), S. 31-46 
    Details
    ISSN: 1588-2861
    Source: Springer Online Journal Archives 1860-2000
    Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract Describes a new method of evaluation of scientific output by laboratories engaged in diverse fields of research. This method helps to evaluate those outputs which are quite recent and not amenable to citation analysis. For the purpose of analysis, impact factor of journals in which papers are published are considered. A method for normalisation of impact factor of journals has been described and, normalised impact factors have also been used for the purpose of analysis. It is found that in such analysis normalised impact factor tends to show better results compared to simple impact factor. The analysis helps us to generate numerous performance indicators such as average impact factor and normalised impact factor for each laboratory and the research complex such as CSIR as a whole; average impact factor and normalised impact factor for each scientist of a laboratory and the research complex; spectral distribution of papers falling within various ranges of impact factors and normalised impact factors. By comparing the performances over several years the trend of research activity of each laboratory can also be obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02020912
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  • 9
    Electronic Resource
    Electronic Resource
    Elastostatic analysis of infinite solids using finite elements (1992)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 35 (1992), S. 109-120 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A novel technique is developed to simulate the effects of an infinite elastic solid by using multiple springs having spatially varying stiffnesses. The spring constants are computed by numerical integration of classical solutions for point or line loads in an infinite or semi-infinite elastic mass. Under certain conditions, even the 'exact' values of spring constants may become negative at some nodes. A simple and highly effective algorithm is proposed to remove this computational difficulty. The technique is applied to the computation of displacements and stresses around underground openings. For a circular opening subjected to different stress conditions, spring constants computed by the proposed numerical integration technique are found to be 'identical' to their 'exact' values. Results obtained by the proposed technique for displacements and stresses around circular and non-circular openings are found to be in an excellent agreement with classical and boundary element solutions. The principal advantages of the proposed technique are that an unbounded solid may be simulated by a relatively very small finite model and a standard finite element code requires no modification for its implementation.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620350107
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  • 10
    Electronic Resource
    Electronic Resource
    Analysis of unbounded field problems using dampers (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Communications in Applied Numerical Methods 4 (1988), S. 761-766 
    Details
    ISSN: 0748-8025
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A highly efficient damper technique, recently developed for the two-dimensional finite element analysis of hydrodynamic pressures on structures vibrating in an incompressible fluid medium, is generalized and extended to three-dimensional problems. Some numerical examples are presented to demonstrate the effectiveness and efficiency of the proposed damper. The damper technique has potential applications to a wide variety of other field problems.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cnm.1630040609
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