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  • 1
    Electronic Resource
    Electronic Resource
    Hyperglycemia and gluconeogenesis in the liver of mice with tumors (1974)
    Springer
    Bulletin of experimental biology and medicine 78 (1974), S. 770-772 
    Details
    ISSN: 1573-8221
    Keywords: gluconeogenesis ; hyperglycemia ; glucose ; tumor Ca-755
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Gluconeogenesis, when sharply stimulated by exhaustion of the liver glycogen reserves, is one of the factors maintaining the normal blood sugar level in mice with tumors. Hyperglycemia induced by glucose leads to an increase in the liver glycogen content and a decrease in the intensity of gluconeogenesis in control mice and also in mice with tumors. Only in the latter, however, does glycogen synthesis from noncarbohydrate compounds rise again steadily after the injections of glucose are discontinued.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799315
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of hydrocortisone on the blood sugar and glycogenesis in rats with tumors (1974)
    Springer
    Bulletin of experimental biology and medicine 78 (1974), S. 895-897 
    Details
    ISSN: 1573-8221
    Keywords: glycogen synthesis ; liver ; hydrocortisone ; Zajdela's hepatoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In fasting control rats and rats with tumors most exogenous glucose-C14 is utilized for glycogen synthesis in the liver only during the first 3 h after administration of hydrocortisone. In fasting rats with Zajdela's hepatoma the threshold of sensitivity of the liver tissue to the induction of glycogen synthesis by hydrocortisone and to the final hyperglycemic effect of this hormone is raised. The substrate induction of glycogenesis in the liver is not disturbed in rats with tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00803920
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  • 3
    Electronic Resource
    Electronic Resource
    Possible nuclease activity of the T-antigen of virus SV-40 (1975)
    Springer
    Bulletin of experimental biology and medicine 79 (1975), S. 46-49 
    Details
    ISSN: 1573-8221
    Keywords: virus carcinogenesis ; T-antigen of virus SV-40 ; nuclease activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A preparation of the T-antigen of virus SV-40 was isolated from an extract of golden hamster tumors by precipitation with ammonium sulfate followed by fractionation on DEAE-cellulose. Despite 100-fold purification of the preparation it contained traces of cell proteins as impurities. Treatment of calf thymus DNA with the preparation of T-antigen in the presence of magnesium ions considerably reduced the viscosity of the DNA solution during the first hour of incubation. The T-antigen, if inactivated by heating, or the analogous fraction from normal hamster tissues had no such action. During centirfugation in a sucrose gradient the sedimentation constant of hamster DNA was reduced after treatment with T-antigen from 28 S to 16 S, corresponding to a reduction of about 4–5 times in the molecular weight of the DNA. It can be concluded from these results that the partially purified preparation of T-antigen of virus SV-40 possesses endonuclease activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00805503
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  • 4
    Electronic Resource
    Electronic Resource
    Interaction between dexamethasone receptor complexes and isolated nuclei from zajdela hepatoma and rat liver cells (1978)
    Springer
    Bulletin of experimental biology and medicine 86 (1978), S. 1229-1233 
    Details
    ISSN: 1573-8221
    Keywords: dexamethasone ; hormone-receptor complex ; acceptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract For translocation of hormone-receptor complexes (HRC) from the cytosol of the hepatoma and rat liver into the nuclei temperature activation of the HRC is necessary. It was shown by saturation analysis that compared with the amount of HRC which normal liver nuclei bind from the homologous cytosol of the same tissue (3 pmoles/mg DNA), hepatoma nuclei bind only onetwentieth as much HRC from homologous hepatoma cytosol (0.15 pmole/mg DNA) but twice as much HRC from heterologous liver cytosol (5.6 pmole/mg DNA). The order of the association constants (Ka) for HRC with the acceptor sites in the nuclei of the hepatoma and liver is practically identical. It is suggested that inhibition of HRC translocation from the cytosol of hepatoma cells into their nucleus is the probable reason why these cells do not respond to hormone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00845037
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  • 5
    Electronic Resource
    Electronic Resource
    Changes in relations between two pathways of synthesis of RNA precursors in the tissues of animals with fast growing hepatomas (1979)
    Springer
    Bulletin of experimental biology and medicine 87 (1979), S. 264-266 
    Details
    ISSN: 1573-8221
    Keywords: RNA synthesis ; “reserve” pathway ; fast-growing hepatoma ; systemic action of tumors ; immunocompetent organs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The ratio between the de novo and “reserve” pathways of synthesis of pyrimidine nucleotides of RNA changes in the de novo direction in the spleen, thymus, and liver of mice and rats with fast growing transplantable hepatomas. This phenomenon is due to a sharp decrease in uridine utilization by the tissues of the tumor-bearing animal, for the tumor utilizes mainly this precursor to synthesize RNA. This observation is regarded as the result of successful competition between the tumor and the host tissues for vitally important metabolites, one form of systemic action of the malignant tumor
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801794
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  • 6
    Electronic Resource
    Electronic Resource
    Insulin and glucocorticoid levels in animals with transplanted tumors (1979)
    Springer
    Bulletin of experimental biology and medicine 88 (1979), S. 894-897 
    Details
    ISSN: 1573-8221
    Keywords: tumor ; hypoglycemia ; gluconeogenesis ; insulin ; glucocorticoids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In mice with Ehrlich's ascites carcinoma and in rabbits with Brown—Pearce carcinoma, hypoglycemia was shown not to be the result of hyperinsulinemia. In rats with Zajdela's ascites hepatoma normoglycemia was the rule, and their blood insulin level did not change during growth of the tumor. The fall in the blood glucose level of rabbits with tumors was not due to weakening of the glucocorticoid function of the adrenals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00869227
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  • 7
    Electronic Resource
    Electronic Resource
    The blood sugar in mice during growth of Ehrlich's carcinoma (1973)
    Springer
    Bulletin of experimental biology and medicine 75 (1973), S. 654-656 
    Details
    ISSN: 1573-8221
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00784682
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  • 8
    Electronic Resource
    Electronic Resource
    Differences in the fractional composition of cytoplasmic RNP particles in Zajdela ascites hepatoma cells and the liver cells of animals with tumors (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1693-1696 
    Details
    ISSN: 1573-8221
    Keywords: Cytoplasmic mRNA ; cytoplasmic RNP particles ; hepatoma ; liver of tumorbearing animals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The relative content of poly(A)-RNA in the cytoplasm is higher in cells of Zajdela's ascites hepatoma and of the liver of rats with tumors than in normal rat liver cells. Another distinguishing feature of the tumor cells (and also, to a lesser degree, of the liver cells of animals with tumors) is a change in the ordinary ratio between polyribosomes and monoribosomes (and, correspondingly, between mRNP particles and informosomes) for normal liver cells in favor of the latter, indicating the occurrence of definite changes in their protein-synthesizing apparatus. According to some of the indices investigated, cells of tumor-bearing animals occupy an intermediate position between normal and tumor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00790388
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  • 9
    Electronic Resource
    Electronic Resource
    Reactivity of the liver to glucocorticoids during chemical hepatocarcinogenesis (1979)
    Springer
    Bulletin of experimental biology and medicine 87 (1979), S. 273-276 
    Details
    ISSN: 1573-8221
    Keywords: dexamethasone ; hepatocarcinogenesis ; enzymes ; DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Liver cells during chemical carcinogenesis (3′-methyldimethylaminoazobenzene) and cells of primary hepatomas retain the property of reacting to partial hepatectomy by increased incorporation of3H-thymidine into DNA, just as under normal conditions this process is inhibited by dexamethasone. The inducibility of tyrosine aminotransferase (EC 2.6.1.5) likewise remained unchanged, whereas induction of tryptophan pyrrolase (EC 1.13.11.11) in primary hepatomas was abolished. The adequacy of a model of chemical carcinogenesis of an organ if the heterogeneity of its cell populations is disregarded is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801797
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  • 10
    Electronic Resource
    Electronic Resource
    Fractionation of chromatin based on strength of binding with the matrix (1980)
    Springer
    Bulletin of experimental biology and medicine 89 (1980), S. 136-138 
    Details
    ISSN: 1573-8221
    Keywords: matrix ; chromatin ; fractionation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract By washing and subsequent centrifugation of rat liver nuclei in medium of low ionic strength the chromatin can be separated into two fractions: Chromatin eluting into the supernatant and chromatin firmly bound with the matrix. The chromatin fraction eluting into the supernatant contains about 60–70% of the original DNA and about 15% of the original protein. It has a complete set of histones and only a small quantity of nonhistone proteins. The RNA-synthesizing ability of chromatin firmly bound with the matrix is 2–3 times greater than that in the original nuclei. Data on gradient centrifugation do not allow the increase in uptake of label to be ascribed entirely to the approximately equal lengthening of chains of synthesized RNA. The increase in ability to synthesize RNA is evidently due to the larger number of molecules of RNA-polymerase per unit of DNA in the chromatin fraction firmly bound with the matrix. Comparison of the results with data in the literature indicates that the chromatin fraction bound with the matrix is enriched with transcribable genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00831000
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