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  • 1
    Digitale Medien
    Digitale Medien
    Proteolysis of glutamate receptor-interacting protein by calpain in rat brain: implications for synaptic plasticity (2001)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 77 (2001), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Activation of the calcium-dependent protease calpain has been proposed to be a key step in synaptic plasticity in the hippocampus. However, the exact pathway through which calpain mediates or modulates changes in synaptic function remains to be clarified. Here we report that glutamate receptor-interacting protein (GRIP) is a substrate of calpain, as calpain-mediated GRIP degradation was demonstrated using three different approaches: (i) purified calpain I digestion of synaptic membranes, (ii) calcium treatment of frozen–thawed brain sections, and (iii) NMDA-stimulated organotypic hippocampal slice cultures. More importantly, calpain activation resulted in the disruption of GRIP binding to the GluR2 subunit of α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors. Because GRIP has been proposed to function as an AMPA receptor-targeting and synaptic-stabilizing protein, as well as a synaptic-organizing molecule, calpain-mediated degradation of GRIP and disruption of AMPA receptor anchoring are likely to play important roles in the structural and functional reorganization accompanying synaptic modifications in long-term potentiation and long-term depression.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.2001.00359.x
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  • 2
    Digitale Medien
    Digitale Medien
    Ligand-Gated Ion Channel Interactions with Cytoskeletal and Signaling Proteins (2000)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 62 (2000), S. 755-778 
    Details
    ISSN: 0066-4278
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Medizin , Biologie
    Notizen: Abstract In recent years, it has become apparent that ligand-gated ion channels (ionotropic receptors) in the neuronal plasma membrane interact via their cytoplasmic domains with a multitude of intracellular proteins. Different classes of ligand-gated channels associate with distinct sets of intracellular proteins, often through specialized scaffold proteins containing PDZ domains. These specific interactions link the receptor channel to the cortical cytoskeleton and to appropriate signal transduction pathways in the cell. Thus ionotropic receptors are components of extensive protein complexes that are likely involved in the subcellular targeting, cytoskeletal anchoring, and localized clustering of the receptors at specific sites on the neuronal surface. In addition to structural functions, receptor-associated proteins can play important roles as activity modulators or downstream effectors of ligand-gated channels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.physiol.62.1.755
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  • 3
    Digitale Medien
    Digitale Medien
    PDZ DOMAINS AND THE ORGANIZATION OF SUPRAMOLECULAR COMPLEXES (2001)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 24 (2001), S. 1-29 
    Details
    ISSN: 0147-006X
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Biologie , Medizin
    Notizen: Abstract PDZ domains are modular protein interaction domains that bind in a sequence-specific fashion to short C-terminal peptides or internal peptides that fold in a beta-finger. The diversity of PDZ binding specificities can be explained by variable amino acids lining the peptide-binding groove of the PDZ domain. Abundantly represented in Caenorhabditis elegans, Drosophila melanogaster, and mammalian genomes, PDZ domains are frequently found in multiple copies or are associated with other protein-binding motifs in multidomain scaffold proteins. PDZ-containing proteins are typically involved in the assembly of supramolecular complexes that perform localized signaling functions at particular subcellular locations. Organization around a PDZ-based scaffold allows the stable localization of interacting proteins and enhances the rate and fidelity of signal transduction within the complex. Some PDZ-containing proteins are more dynamically regulated in distribution and may also be involved in the trafficking of interacting proteins within the cell.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1146/annurev.neuro.24.1.1
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  • 4
    Digitale Medien
    Digitale Medien
    Changing subunit composition of heteromeric NMDA receptors during development of rat cortex (1994)
    [s.l.] : Nature Publishing Group
    Nature 368 (1994), S. 144-147 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] NR1-FP antibodies, which are raised against NR1 fusion proteins and should recognize all known splice forms of the NR1 subunit9'10, bind to a heterogeneous band of relative molecular mass (A/r) 120K on immunoblots of rat brain membranes (Fig. 1), in agreement with the reported size of the NR1 ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/368144a0
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  • 5
    Digitale Medien
    Digitale Medien
    Glutamate receptors put in their place (1997)
    [s.l.] : Nature Publishing Group
    Nature 386 (1997), S. 221-223 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Nerve cells transmit signals to one another through synapses. Effective transmission of these impulses requires the precise localization and high concentration of neurotransmitter receptors on the receiving, postsynaptic, side of the synapse. The molecular mechanisms of this targeted clustering ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/386221a0
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  • 6
    Digitale Medien
    Digitale Medien
    corrigendum: Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2 (2002)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 417 (2002), S. 205-205 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Nature 404, 298–302 (2000). In this Letter, we numbered some nucleotides for the upstream region of the reelin gene incorrectly. The Reelin-luc construct contains an upstream region of the reelin gene corresponding to nucleotides ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/417205a
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  • 7
    Digitale Medien
    Digitale Medien
    Clustering of Shaker-type K + channels by interaction with a family of membrane-associated guanylate kinases (1995)
    [s.l.] : Nature Publishing Group
    Nature 378 (1995), S. 85-88 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The amino-terminal intracellular region of voltage-gated K+ channel a-subunits contains a proximal domain involved in sub-unit multimerization5, and a distal flexible 'ball peptide' responsible for rapid inactivation of the channel6. We reasoned therefore that potential anchoring molecules would ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/378085a0
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  • 8
    Digitale Medien
    Digitale Medien
    Presynaptic A-current based on heteromultimeric K + channels detected in vivo (1993)
    [s.l.] : Nature Publishing Group
    Nature 365 (1993), S. 72-75 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Using in situ hybridization, Kvl.4 and Kvl.2 messenger RNAs exhibit distinct but overlapping expression patterns in rat brain, with co-expression in many neurons7'8. The Kvl.4 protein appears to be localized specifically to axons and terminals of neurons that express this gene7. Immunostaining of ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/365072a0
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  • 9
    Digitale Medien
    Digitale Medien
    Neurobiology Glutamate receptors on the move (2002)
    [s.l.] : Nature Publishing Group
    Nature 417 (2002), S. 601-602 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Neurons communicate with each other at specialized junctions known as synapses. In excitatory synapses of the brain, a signal-transmitting (presynaptic) neuron secretes glutamate — a chemical messenger that diffuses across the synaptic 'cleft' to bind to glutamate receptors concentrated in ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/417601a
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  • 10
    Digitale Medien
    Digitale Medien
    Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2 (2000)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 404 (2000), S. 298-302 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] Membrane-associated guanylate kinases (MAGUKs) contain multiple protein-binding domains that allow them to assemble specific multiprotein complexes in particular regions of the cell. CASK/LIN-2, a MAGUK required for EGF receptor localization and signalling in Caenorhabditis elegans, ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/35005118
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