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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 100 (1993), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine the accuracy of the SpaceLabs 90207 ambulatory blood pressure monitor in pregnant women.Design Prospective observational study.Setting Queen Charlotte's and Chelsea Hospital for Women.Subjects One hundred and twenty-two pregnant women from the antenatal population of Queen Charlotte's Hospital.Methods Evaluation was carried out according to the British Hypertension Society (BHS) Protocol.Results The mean difference between observer and device for systolic blood pressure was 3 (SD 4) mmHg. For diastolic blood pressure the difference was 5 (SD 6) mmHg for Phase IV (muffling of Korotkoff sound), and 4 (SD 4) mmHg for Phase V (disappearance of Korotkoff sound). According to the BHS grading criteria, the device reached a B grading for systolic blood pressure. B grading was also reached for diastolic blood pressure (Phase V) but grade C for diastolic blood pressure (Phase IV). The accuracy criteria stipulated by the Association for the Advancement of Medical Instrumentation (AAMI) were also met for both systolic and diastolic blood pressure.Conclusion The SpaceLabs 90207, when compared with trained observers, is accurate in determining both systolic and diastolic blood pressure for clinical purposes, as judged by the BHS Protocol in pregnancy.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective  To assess the safety and efficacy of the long term prophylactic use of rofecoxib (a COX-2-specific inhibitor) in women at high risk of preterm delivery.Design  A randomised, double-blind, placebo-controlled trial.Setting  Queen Charlotte's and Chelsea Hospital, London and Guys and St Thomas' Hospitals, London.Population  Ninety-eight singleton pregnancies at high risk of preterm labour.Methods  Treatment from 16 to 32 weeks. Weekly ultrasound surveillance.Main outcome measures  Fetal renal function and ductus arteriosus blood flow changes. Preterm delivery rates and neonatal outcome.Results  Rofecoxib caused a reduction in hourly fetal urine production rates (−34%, 95% CI −13 to −50%, P= 0.004) and amniotic fluid index (−2.2, 95% CI −3.2 to −1.2, P 〈 0.001). This effect did not increase with time on treatment and reversed in all cases on discontinuation of treatment. Rofecoxib had an effect on the ductus arteriosus, increasing maximum systolic velocity (0.1 m/s, 95% CI 0.03–0.16, P= 0.02) and minimum diastolic velocity (0.007 m/s, 95% CI 0.0007–0.013, P= 0.03). This effect increased with time on treatment but was reversed with discontinuation of treatment and had no long term clinical sequelae. There was no difference in preterm delivery rates 〈30 weeks (28% on placebo vs 33% on rofecoxib, Mantel–Haensel [M–H]-adjusted risk 1.11, 95% CI 0.67–1.87). There were more deliveries 〈37 weeks in those on rofecoxib (40%vs 67%, M–H-adjusted risk 1.59, 95% CI 1.09–2.32). Rates of preterm prelabour rupture of membranes (PPROM) were higher in those on rofecoxib (RR 2.5, 95% CI 1.3–4.7).Conclusion  Rofecoxib has a significant but reversible effect on fetal renal function and the ductus arteriosus. It does not reduce the incidence of early preterm delivery 〈30 weeks and is associated with an increased risk of delivery before 37 weeks in women at high risk.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To assess the accuracy of the Omron HEM 705 CP oscillometric device for the measurement of blood pressure in pregnancy and pre-eclampsia.Setting Two teaching hospitals.Participants Eighty-five pregnant women with a wide range of blood pressures, and 43 women with pre-eclampsia.Methods Evaluation was carried out according to the British Hypertension Society protocol, incorporating criteria of the Association for the Advancement of Medical Instrumentation (AAMI).Results Mean differences (device minus observer) for systolic blood pressure were −0.9 mmHg (SD 10) in normal pregnancy, and −2 mmHg (SD 10) in the women with pre-eclampsia. For diastolic blood pressure, Korotkoff phase V, the differences were −1.5 mmHg (SD 10), and −8 mmHg (SD 8) respectively; i.e. the device consistently under-read the diastolic blood pressure in pre-eclamptic women by a mean of 8 mmHg when compared with conventional sphygmomanometry. Korotkoff phase IV could not be accurately reproduced. According to the British Hypertension Society grading criteria, the device reached a ‘B’ grading in the 85 pregnant women. In pre-eclampsia only a ‘C’ grade was reached for systolic blood pressure, and ‘D’ grade for diastolic blood pressure. Accuracy criteria stipulated by the AAMI were not met in any situation.Conclusion The Omron HEM 705 CP does not reach acceptable accuracy criteria for blood pressure measurement when compared with trained observers in women with pre-eclampsia, as judged by the British Hypertension Society Protocol. It also failed to meet the AAMI criteria, although the methodology stipulated by the AAMI may not be applicable to a pregnancy population.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine the role of inter–observer error and the influence of training upon dipstick urine analysis.Design A two phase observational and training studyMethods Five standard solutions of serum albumin were used to test the accuracy of midwives and nursing auxiliaries involved in dipstick urine analysis at a maternity hospital. The standard solutions were chosen such that they should have resulted in negative (n= 2) and positive (n= 3) dipstick test results, respectively.Setting A teaching maternity hospital and academic department of obstetrics and gynaecology.Participants Twenty midwives, 20 nursing auxiliaries and nine laboratory technicians.Results For the two nonproteinuric solutions, a higher false positive rate was observed for nursing auxiliaries(40% and 55%), compared with midwives (5% and 30%) (P= 0.020 and P= 0.20, respectively). Before training, laboratory technicians recorded high false positive rates (67% and 89%), but after training these were reduced to 0% and 22% (P= 0.25 and P= 0.023, respectively). Both nursing auxiliaries and midwives recorded false negative rates of between 10% and 45% for the three proteinuric solutions.Conclusions Observer error may be reduced by assigning midwives to urine dipstick analysis or by the implementation of directed training. Classification of pre-eclampsia or other hypertensive diseases of pregnancy on the basis of the presence and degree of proteinuria should be confirmed with a 24–hour quantitative protein collection.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective  To compare semi-quantitative visual and automated methods of urine testing with fully quantitative point of care urinalysis for the detection of significant proteinuria (0.3 g/24 hours) in pregnancy complicated by hypertension.Design  A prospective comparative study.Setting  A large teaching maternity hospital.Sample  One hundred and seventy-one pregnant women referred to the obstetric day-care unit for assessment of newly arisen hypertension.Methods  Early morning urine specimens were tested with four dipstick techniques (Multistix 8SG visual and automated and microalbumin/creatinine ratio visual and automated; Bayer, Elkhart, USA) as well as a fully quantitative measure of the microalbumin creatinine ratio with the DCA 2000 (a point of care assay for albumin; Bayer). These results were compared to a 24-hour urine protein measurement and measures of diagnostic accuracy/prediction are reported.Main outcome measures  Significant proteinuria (≥0.3 g/24 hours) measured by laboratory assay.Results  Automated dipstick urinalysis using the Clinitek 50 has significantly better predictive values for significant proteinuria (LR+ 4.27, 95% CI 2.78 to 6.56; LR− 0.225, 95% CI 0.14 to 0.37) than conventional visual dipstick urinalysis (LR+ 2.27, 95% CI 1.47 to 3.51; LR− 0.635, 95% CI 0.49 to 0.82). Dipstick microalbumin/creatinine ratio testing did not improve overall detection rates with automated or visual testing. Fully quantitative point of care measurement of albumin/creatinine ratio (ACR) was significantly better than any dipstick technique (LR+ 14.6, 95% CI 6.74 to 31.8; LR− 0.069, 95% CI 0.030 to 0.16).Conclusions  This study confirms that in pregnancy automated dipstick urinalysis is a more accurate screening test for the detection of proteinuria than visual testing. ACR testing can offer a significant improvement over conventional urinalysis if a fully quantitative method of detection is employed that uses pregnancy-specific thresholds. Dipstick assessment of ACR does not improve the detection rate of significant proteinuria.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To evaluate the accuracy of the OMRON-MIT inflationary oscillometric device for blood pressure measurement in pregnancy and pre-eclampsia.Design Prospective observational study, using validation methods recommended by the British Hypertension Society (BHS) and the Association for the Advancement of Medical Instrumentation (AAMI).Settings Antenatal clinics and ward, Guy's Hospital, London.Population Normotensive pregnant women and those diagnosed with pre-eclampsia according to the definition of the International Society for the Study of Hypertension in Pregnancy.Methods Validation according to BHS protocol.Main outcome measures Proportion of readings within 5, 10 and 15 mmHg (absolute differences) between the automated device and two trained, blinded observers, according to the BHS and AAMI criteria.Results The OMRON-MIT achieved an overall BHS grade B for systolic and grade A for diastolic blood pressure measurement in both pregnancy and pre-eclampsia. The mean (SD) differences between the standard and the test device were −5 (7) mmHg for systolic and 2 (6) mmHg for diastolic blood pressure in pregnancy and −4 (6) mmHg for systolic and 2 (7) mmHg for diastolic blood pressure in pre-eclampsia. This device therefore fulfils the AAMI criteria.Conclusion The OMRON-MIT is the only automated oscillometric device that has proven to be accurate for blood pressure measurement in pre-eclampsia according to the BHS protocol in pregnancy. Inflationary oscillometry may correct the error associated with oscillometric devices in pre-eclampsia.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    BJOG 108 (2001), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 104 (1997), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 106 (1999), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The most common definition of pre-eclampsia involves hypertension and proteinuria. This has changed little in over a hundred years despite advances in understanding the underlying pathological process. However, a number of variations in definition exist, and this paper demonstrates a lack of consistency in research articles in defining pre-eclampsia. A quarter of papers omit description, and many authors choose their own interpretation of the standard classification. Editors and reviewers should ensure that papers include a clear description of the definition used and an adequate description of the population studied to allow meaningful interpretation of research findings.
    Type of Medium: Electronic Resource
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