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  • 1
    Electronic Resource
    Electronic Resource
    Intracerebral inflammatory response to experimental brain contusion (1995)
    Springer
    Acta neurochirurgica 132 (1995), S. 110-119 
    Details
    ISSN: 0942-0940
    Keywords: CNS trauma ; experimental contusion ; inflammation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The inflammatory reaction following experimental brain contusion was studied by immunohistochemistry in 22 rats during the first 16 days after trauma. An inflammatory mononuclear cell response was evident on day 2, with a maximum on days 5–6 and signs remained still 16 days after the trauma. The time course of the cellular infiltration adjacent to the lesion correlated with blood brain barrier dysfunction in the contralateral side of the traumatized hemisphere. The cellular infiltrate comprised NK cells, T-helper cells and T-cytotoxic/suppressor cells as well as monocytes/macrophages. Most of the macrophages appeared to be activated by T-cells. Surprisingly, polymorphonuclear cells appeared less engaged than mononuclear cells in the inflammation. The demonstration of immunocompetent cells and the induction of MHC-1 and MHC-II antigen provides a substrate for inflammatory reactions similar to those that cause neurological damage in inflammatory diseases such as viral infections, multiple sclerosis and experimental allergic encephalitis. Our observations indicate that the role of the inflammatory reactions may have a role, hitherto neglected, in the pathogenesis of secondary traumatic brain injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404857
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical effects of monoclonal antibody 17-1A combined with granulocyte/macrophage-colony-stimulating factor and interleukin-2 for treatment of patients with advanced colorectal carcinoma (1999)
    Springer
    Cancer immunology immunotherapy 48 (1999), S. 463-470 
    Details
    ISSN: 1432-0851
    Keywords: Key words Colorectal carcinoma ; Monoclonal antibodies ; GM-CSF-IL-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Granulocyte/macrophage-colony-stimulating factor (GM-CSF) has previously been indicated to enhance the therapeutic effect of the anti-colorectal carcinoma mAb17-1A as well as to augment in vivo immune effector functions. In vitro interleukin-2 (IL-2) augmented GM-CSF-induced antibody-dependent cellular cytotoxicity, a mechanism considered to be of significance for the therapeutic effect of mAb. A treatment regimen was elaborated that combined mAb17-1A (400 mg at day 3 of a 10-day treatment cycle) with the simultaneous administration of GM-CSF (250 μmg/m2 once daily) and IL-2 (2.4 × 106 U/m2 twice daily) for 10 days. The treatment cycle was repeated once a month. Twenty patients with advanced colorectal carcinoma were included in the study. One patient obtained a partial remission and 2 patients stable disease for 7 and 4 months respectively. The median survival time from the start of mAb therapy was 8 months. Owing to allergic reactions, the planned mAb17-1A dose had to be reduced by repeated infusions. At the fourth treatment cycle only 25% received the planned mAb dose. In 3 patients the GM-CSF and IL-2 dose was reduced because of side-effects. The subjective tolerability of the treatment was considered good or acceptable in more than 80% of the patients. The increment in white blood cell subsets induced by the cytokines decreased by increasing number of courses. This particular regimen did not augment the therapeutic effect of mAb17-1A anticipated from in vitro data but rather hampered the clinical effect of the antibody. The reason for this is not clear but a possibility might be the induction of immune suppression in vivo resulting from an impaired human anti-(mouse Ab) and anti-idiotypic antibody response as well as antibody-dependent cellular cytotoxicity, on the basis of a comparison of mAb17-1A/GM-CSF/IL-2- and mAb17-1A/GM-CSF-treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050623
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ear tumours induced by experimental carcinogenesis in the rat: excision prevents early death (1994)
    Springer
    International journal of colorectal disease 9 (1994), S. 125-127 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La 1,2 dimethylhydrazine (DMH) est largement utilisée pour induire des tumeurs colo-rectales chez les rongeurs. Quelques animaux développent des tumeurs de l'oreille au même titre que des tumeurs colo-rectales. Les rats porteurs de larges tumeurs exulcérées de l'oreille sont sacrifiés habituellement avant la fin de l'expérimentation. Dans cette étude, 46 rats mâles Spraque-Dawley ont reçu par injection de la 1,2 dimethylhydrazine (21 mg/kg de poids corporel) une fois par semaine durant 27 semaines afin d'étudier l'histo-génèse des cancers colo-rectaux. Trente-six ont développé des tumeurs de l'oreille, 14 de ces 36 tumeurs mesuraient plus de 2 cm de diamètre. Elles se développent entre la 20 et la 26e semaine et ont été excisées chirurgicalement 1 à 5 semaines plus tard. Quatre rats sont morts dans la période post-opératoire. L'excision chirurgicale des larges tumeurs de l'oreille a permis de compléter le programme d'expérimentation colique (sur 27 semaines) chez 10 (28%) des 36 rats porteurs des tumeurs de l'oreille.
    Notes: Abstract 1,2-dimethylhydrazine (DMH) is widely used to induce colorectal tumours in rodents. Some of the animals develop ear as well as colorectal tumours. Rats with large, ulcerated ear tumours are usually sacrificed before the completion of the experiment. In this experiment, fourty-six male Spraque-Dawley rats were injected with 1,2-dimethylhydrazine (21 mg/kg body weight) once a week for 27 weeks to study the histogenesis of colorectal carcinoma. Thirty-six developed ear tumours. Fourteen of the 36 tumours were larger than 2 cm in diameter. These developed between 20–26 weeks and were surgically excised 1–5 weeks later. Four rats died postoperatively. The surgical removal of large ear tumours permitted the completion of the large bowel experiment on schedule (i.e. 27 weeks) in 10 (28%) of the 36 rats with ear tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290187
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    Paper (German National Licenses)
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