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  • 1
    Electronic Resource
    Electronic Resource
    Skin surgery in patients 90 years of age and over (1998)
    Oxford, UK : Blackwell Science Ltd
    International journal of dermatology 37 (1998), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The number of aged people is increasing. It is conceivable that we will be treating considerably more aged patients with more surgical risk factors in the very near future. Methods During the period between 1976 and 1996, 212 patients of 80 years of age and older underwent skin surgery at the Mie University Hospital, Japan. Among them, 25 patients of 90 years of age and over were studied. Results Fourteen patients (56.0%) have undergone skin surgery in the past 5 years; 22 patients (88.0%) had skin tumors on the face and ears; squamous cell carcinoma was found in 17 patients (68.0%), while basal cell carcinoma was seen in four patients (16.0%). Despite their advanced ages, half of the patients had no medical contraindications to performing surgery. Conclusions Careful preoperative management may allow more cutaneous surgery to be carried out in aged people.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-4362.1998.00380.x
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  • 2
    Electronic Resource
    Electronic Resource
    INVOLVEMENT OF ENDOTHELIAL CYCLO-OXYGENASE METABOLITES IN NORADRENALINE-INDUCED CONTRACTION OF RAT CORONARY ARTERY (2005)
    Oxford, UK : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 32 (2005), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Noradrenaline (NA; 0.3 µmol/L) caused a contraction of the rat coronary artery that markedly increased in the presence of the nitric oxide synthase (NOS) inhibitor NG-nitro-l-arginine methyl ester (l-NAME; 100 µmol/L) and arachidonic acid (1 µmol/L; P 〈 0.05).2. The present experiments attempted to elucidate the endothelium dependency of the contraction and to pharmacologically characterize the factors involved in the contraction induced by NA (0.3 µmol/L) in the presence of l-NAME and arachidonic acid in ring preparations of the rat coronary artery.3. The NA (0.3 µmol/L)-induced contraction was attenuated by a chemical remover of the endothelium (saponin at concentrations of 0.1 and 0.4 mg/mL) in a concentration-dependent manner (P 〈 0.05).4. The cyclo-oxygenase (COX)-1 inhibitor flurbiprofen (0.01–1 µmol/L) and the COX-2 inhibitor nimesulide (0.01–1 µmol/L) attenuated the NA-induced contraction in a concentration-dependent manner and the inhibitory effect of flurbiprofen was significantly more potent than that of nimesulide (P 〈 0.05). The 5-lipoxigenase inhibitor ZM-230487 (1 µmol/L) did not affect the NA-induced contraction.5. The thromboxane A2 (TXA2) synthetase inhibitor OKY-046 (30 µmol/L) and the TXA2 antagonist S-1452 (0.1–10 µmol/L) did not attenuate the NA-induced contraction.6. These results indicate that the contraction induced by NA in the rat coronary artery in the presence of l-NAME and arachidonic acid is endothelium dependent and is due to endothelial COX metabolites of arachidonic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0305-1870.2005.04242.x
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  • 3
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    INDUSTRY AND BUSINESS IN JAPAN ed. by Kazuo Sato (Book Review) (1981)
    Tokyo : Periodicals Archive Online (PAO)
    Japan Quarterly. 28:3 (1981:July/Sept.) 432 
    Details
    ISSN: 0021-4590
    Topics: Sociology , Economics
    Notes: BOOKS
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:6125-1981-028-03-000019
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  • 4
    Electronic Resource
    Electronic Resource
    Evaluation of nicotine, cotinine, thiocyanate, carboxyhemoglobin, and expired carbon monoxide as biochemical tobacco smoke uptake parameters (1988)
    Springer
    International archives of occupational and environmental health 60 (1988), S. 37-41 
    Details
    ISSN: 1432-1246
    Keywords: Tobacco smoking ; Dosimetry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a cross-sectional study on 236 individuals in Japan (174 males, 62 females; 149 smokers, 87 non-smokers) plasma nicotine (pnic), cotinine (pcot) and thiocyanate (pSCN), urinary creatinine ratios of nicotine (unic), cotinine (ucot) and thiocyanate (uSCN) as well as carboxyhemoglobin (COHb) and expired carbon monoxide (COex) were determined. All tobacco smoke uptake parameters (TSUP) were significantly elevated in smokers as compared to non-smokers. The discriminant power (smokers vs non-smokers) rank in the following order: ucot ∼ pcot ∼ unic 〉 pSCN ∼ COHb ∼ pnic 〉 COex ∼ uSCN. All parameters except for pnic are significantly correlated with the self-reported number of cigarettes smoked per day. The reason for the poor correlation of pnic with daily cigarette consumption is the short half-life of pnic coupled with the arbitrary time of blood drawing in relation to the last time of smoking.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00409377
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