ISSN:
1432-0584
Keywords:
Multiple myeloma
;
Common acute lymphoblastic leukemia antigen (CALLA)
;
Renal failure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Four patients with common acute lymphoblastic leukemia antigen (CALLA)-positive myeloma are presented. The subclasses of monoclonal protein were IgDκ (1 case), IgAλ (1 case), and IgAκ (2 cases). Bence Jones proteinuria was seen in all cases. The clinical stages were determined as IIA (2 cases) and IIIA (2 cases). All patients died with a median survival time after diagnosis of 62 days due to rapid development of renal failure (3 cases), and renal insufficiency and pneumonia (1 case). According to light microscopic evaluation, these myelomas corresponded to plasmablastic (1 case), immature (2 cases), and intermediate (1 case) types. Both CALLA and a cytoplasmic immunoglobulin identical with the serum monoclonal protein were simultaneously detected in single cells from all cases using immunofluorescent double labeling. These findings suggest that CALLA-positive and plasmablastic myelomas constitute clinically a subgroup characterized by extremely poor survival but they represent cytologically different subcategories.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320910
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