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  • 1
    Electronic Resource
    Electronic Resource
    Transplantation of ACTH-secreting pituitary tumor cells in athymic nude mice (1982)
    Springer
    Virchows Archiv 396 (1982), S. 303-312 
    Details
    ISSN: 1432-2307
    Keywords: Athymic nude mice ; ACTH pituitary tumor ; Cushing's syndrome ; Adrenal ; Glucocorticoids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chronic excess of glucocorticoids results in cushing's syndrome in humans. A common cause of excess cortisol secretion is the presence of an adrenocorticotropin secreting pituitary tumor which stimulates the adrenal cortex to produce excess glucocorticoids. ACTH-secreting AtT-20 mouse pituitary cells transplanted subcutaneously in oestrogenized athymic nude mice form tumors rapidly. Six weeks after receiving the tumor transplants, the mice weighed 45% more than normal mice due to the increase in body fat. The tumor-bearing mice exhibit the familiar “buffalo hump” appearance due to the abnormal distribution of body fat. The adrenal glands of the tumor-bearing animals are enlarged due to hypertrophy of the zona fasciculata. The foamy looking fasciculata cells in normal mice were converted to dense, eosinophilic cells in the tumor-bearing mice. Transplantation of normal pituitary glands to athymic nude mice with or without oestrogen treatment did not produce these morphological changes. The experimental model described here may be useful for future studies of Cushing's syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431389
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  • 2
    Electronic Resource
    Electronic Resource
    The gene for prolactin-inducible protein (PIP), uniquely expressed in exocrine organs, maps to chromosome 7 (1989)
    Springer
    Somatic cell and molecular genetics 15 (1989), S. 265-270 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The hormonally responsive prolactin-inducible protein (PIP), gene is expressed in benign and malignant breast tumor tissues and in such normal exocrine organs as sweat, salivary, and lacrimal glands. In this communication we report the regional chromosome localization of the PIPgene locus to chromosome 7 by Southern hybridization to DNA from human-hamster somatic cell hybrids, and to 7q32–36 by in situ hybridization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01534877
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    Paper (German National Licenses)
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