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  • 1
    Electronic Resource
    Electronic Resource
    Solid-State Emulsions: The Effects of Maltodextrin on Microcrystalline Aging (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 1389-1391 
    Details
    ISSN: 1573-904X
    Keywords: self-emulsification ; reconstitutable emulsions ; maltodextrins ; solid-state stability ; emulsifiable glasses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018998519907
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Solid-State Emulsions: Evaluation by 1H and 13C Solid-State Nuclear Magnetic Resonance (1994)
    Springer
    Pharmaceutical research 11 (1994), S. 1301-1305 
    Details
    ISSN: 1573-904X
    Keywords: emulsifiable glass ; self-emulsification ; solid state emulsion ; inclusion compound and CRAMPS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The molecular environment of sucrose and mineral oil within sucrose and mineral oil solid state emulsions was investigated by NMR techniques. The 13C and 1H chemical shifts of sucrose and mineral oil to those observed in solid state emulsions (comprised of sucrose and mineral oil) were equivalent, indicating that the local structure of sucrose is unaffected by the presence of mineral oil in the solid-state emulsion. Cross-polarization, magic angle spinning 13C (CP-MAS) in conjuncton with single-pulse studies indicated that the 1H-13C dipole-dipole interactions are very weak, i.e., mineral oil is highly mobile. Spinning side bands were observed, however, in 1H single-pulse, magic angle spinning (SPMAS) spectra of the solid-state emulsion, indicating that the mineral oil has solid properties. Although the mineral oil was shown to be highly mobile, it also appears to be constrained or included by the sucrose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018946512445
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Solid-State Emulsions: The Effects of Process and Storage Conditions (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 1071-1075 
    Details
    ISSN: 1573-904X
    Keywords: self-emulsification ; glass ; solid transformation ; self-emulsifiable solid ; emulsifiable glass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The effects of process and storage conditions of solid-state emulsions were studied. Oil-in-water emulsions may be prepared from solid state emulsions by adding an aqueous phase to the solid. Solid-state emulsions are prepared by processing an oil phase and an aqueous solution of matrix material via a solvent removal process. Sucrose, the carrier material utilized in this report, results in a metastable solid or glass, which can transform upon aging to a more stable thermodynamic state. Aging was determined by monitoring the crystallinity as a function of time, temperature, relative humidity, and grinding. The crystallinity of solid-state emulsions was determined with X-ray diffraction and differential scanning calorimetry. Results indicate that solid-state emulsions should be stored between 15 and 25% relative humidity at 25°C. Grinding has no apparent effect on the crystallinity of the sample, as detected by X-ray diffraction, although the microcrystallinity is increased. The utilization of silinized glassware enabled the sample-to-sample microcrystalline variability to be reduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018983227234
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of Oil-in-Water Emulsions Prepared from Solid-State Emulsions: Effect of Matrix and Oil Phase (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 1153-1156 
    Details
    ISSN: 1573-904X
    Keywords: microemulsion ; drug delivery ; reconstitutable emulsions ; particle size
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Emulsions (o/w) were prepared from solid-state emulsions comprised of various matrix materials and oils and the resultant particle size properties determined. Results suggest that for those matrices that can form solid-state emulsions, the droplet size decreased as a function of time, as previously observed. The final droplet size was dependent on the oil utilized but was independent of the matrix material. The use of mineral oil resulted in the smallest droplet diameter (∼1.5 µm) while isopropyl myristate resulted in the largest droplet diameter (∼3 µm). With the exception of mineral oil, the oil/water interfacial tension was found to be directly proportional to the droplet diameter. The rate of emulsification appeared to be bi-phasic. The initial emulsification phase appeared to be independent of the matrix material while the terminal phase was a function of the matrix material. Most importantly, it was found that solid state emulsions could be prepared from a diverse, yet specific, list of matrices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018912100826
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    Paper (German National Licenses)
    Fulltext
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