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  • 1
    Electronic Resource
    Electronic Resource
    Some Amino Acid-Folic Acid Interrelationships in Tetrahymena pyriformis (1961)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 8 (1961), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: DL-serine, DL-methionine or DL-serine + DL-methionine in excess inhibited the growth of Tetrahymena pyriformis H. Excess serine was most inhibitory at high concentration of folic acid, whereas the effect of excess methionine or methionine + serine was most pronounced at low levels of folic acid. Inhibition due to excess serine was relieved by raising the level of methionine or by adding pyrimethamine to lower the effective folic acid level, and was intensified by adding Dl.-ethionine or by raising the level of folic acid. Similarly, inhibition due to excess methionine was relieved by supplying more serine or adding DL-ethionine (which reduced the amount of available methionine) and was intensified by adding pyrimethamine. Inhibition by excess methionine + serine was reversed by increasing threonine, provided there was ample guanine present. Low levels of guanine or the presence of 8-azaguanine prevented this reversal. Comparisons are made with the work of others.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1961.tb01214.x
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  • 2
    Electronic Resource
    Electronic Resource
    MICROBIOLOGICAL EFFECTS OF 6-MERCAPTOPURINE (1954)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 60 (1954), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1954.tb40009.x
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  • 3
    Electronic Resource
    Electronic Resource
    DEFINED MEDIA FOR THE STUDY OF BACILLI PATHOGENIC TO INSECTS (1966)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 139 (1966), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1966.tb41181.x
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  • 4
    Electronic Resource
    Electronic Resource
    Differentiation and reversal of malignant changes in colon cancer through PPARγ (1998)
    [s.l.] : Nature America Inc.
    Nature medicine 4 (1998), S. 1046-1052 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] PPARγ is a nuclear receptor that has a dominant regulatory role in differentiation of cells of the adipose lineage, and has recently been shown to be expressed in the colon. We show here that PPARγ is expressed at high levels in both well- and poorly-differentiated adenocarcinomas, in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2030
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  • 5
    Electronic Resource
    Electronic Resource
    Correlation of lipid content and composition with liposarcoma histology and grade (1997)
    Springer
    Annals of surgical oncology 4 (1997), S. 557-563 
    Details
    ISSN: 1534-4681
    Keywords: Liposarcoma ; Lipids ; 13C-NMR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The determination of sarcoma grade, histologic type, and differentiation is often pathologist dependent and requires considerable expertise. Methods: Lipid content and composition was analyzed in ex vivo fat, lipoma, and liposarcoma tissue samples using proton-decoupled13C nuclear magnetic resonance (13C-NMR) spectroscopy and correlated with the histologic type and grade of liposarcoma. Results: The well-differentiated liposarcomas were found to have threefold increases in fatty acyl chain content compared with benign lipomas. The fatty acyl chain content of the dedifferentiated and pleomorphic liposarcomas was 1% of that found in lipoma and〈0.2% of that found in well-differentiated liposarcoma. The 2.1- to 2.8-fold increase in the degree of polyunsaturation in the dedifferentiated and pleomorphic liposarcomas compared with well-differentiated liposarcoma could largely be accounted for by the 2.3-fold increase in the percentage of fatty acyl chains of lipid containing linoleic acid. The dedifferentiated and pleomorphic liposarcomas contained both free fatty acids and phospholipids that were not NMR detectable in normal fat, lipoma, and well-differentiated liposarcoma. Conclusion: Ex vivo13C-NMR spectroscopy may be used to distinguish lipoma from well-differentiated, dedifferentiated, and pleomorphic liposarcoma based on changes in lipid and phospholipid metabolite profiles and may serve as adjunct to conventional light microscopy for the determination of liposarcoma histologic type and thus grade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02305536
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  • 6
    Electronic Resource
    Electronic Resource
    Insecticidal Activity of Recent Bacterial Isolates and their Toxins against Mosquito Larvae (1973)
    [s.l.] : Nature Publishing Group
    Nature 244 (1973), S. 110-111 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Bacteria were isolated by plating the WHO/IRC material on brain heart infusion agar and growing it at 30 C for several days. Ninety-one isolates killed Culex pipiens, variety quinquefasciatus (the southern house mosquito): forty of them were identified as B. alvei, B. circulans, or intermediate ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/244110a0
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  • 7
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    THE PHILADELPHIA STORY (1977)
    New York : Periodicals Archive Online (PAO)
    Music journal. 35:7 (1977:Sept.) 22 
    Details
    ISSN: 0027-4364
    Topics: Musicology
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:1166-1977-035-07-000004
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  • 8
    Electronic Resource
    Electronic Resource
    Isolation and description of antimicrobic-resistant (marker) strains of select insecticidal and noninsecticidal varieties ofBacillus sphaericus (1986)
    Springer
    Journal of industrial microbiology and biotechnology 1 (1986), S. 245-250 
    Details
    ISSN: 1476-5535
    Keywords: Antibiotic-resistance ; Bacillus sphaericus ; Insecticidal strain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Single and multiple antibiotic-resistant strains were isolated from four insecticidal and two noninsecticidal parent strains ofBacillus sphaericus. Several of the single resistant strains isolated were also cross-resistant to several antibiotics of different modes of action. All of the parent strains were naturally susceptible to 11 and naturally resistant to two out of 22 antimicrobics examined. The majority, 17 out of 23, of antibiotic-resistant strains, that were isolated from the insecticidal parent strains, retained their insecticidal activity while the noninsecticidal strains remained noninsecticidal. Among the isolates were several strains that would be potentially useful as marker strains in the genetic manipulation of the insecticidal strains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01569278
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  • 9
    Electronic Resource
    Electronic Resource
    Fermentation and toxin studies of the molluscicidal strains ofBacillus brevis (1994)
    Springer
    Journal of industrial microbiology and biotechnology 13 (1994), S. 112-119 
    Details
    ISSN: 1476-5535
    Keywords: MolluscicidalBacillus toxin ; Bacillus brevis ; Biomphalaria glabrata ; Biocontrol of snails ; Antioxidant preservation of toxin ; Secondary fermentation factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Strain SS86-4 was one of 40Bacillus brevis strains shown to be molluscicidal to the schistosomiasis snail vectorBiomphalaria glabrata. When grown in mB4 medium in 2-L fermentors, SS86-4 was molluscicidal only if fructose or phenylalanine was present in the medium. This is reminiscent of secondary fermentation factor effects, in this case an antioxidant effect. In vivo proteases also were capable of reducing molluscicidal activity. The molluscicidal toxin has an LC50 of 1 μg toxin protein ml−1 (approx. 1 p.p.m.) and may be described as a small proteinaceous, heat-stable, oxygen-sensitive entity associated with the particulate portion of the cell wall fraction ofB. brevis that is formed prior to sporulation. Initial information indicates that its HPLC signature shows major peaks at 148.37 and 163.96 s and consists of two bands of approximately 5.3 kDa and 8.7 kDa on PAGE gel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01584108
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  • 10
    Electronic Resource
    Electronic Resource
    Initial studies of the use of aminopeptidases for the differentiation ofBacillus sphaericus strains (1987)
    Springer
    Journal of industrial microbiology and biotechnology 2 (1987), S. 285-292 
    Details
    ISSN: 1476-5535
    Keywords: Dendrogram ; Insecticidal strain ; Multilocus pattern ; Polyacrylamide gel electrophoresis ; Microbial insecicide ; Bacillus sphaericus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Analysis of aminopeptidase activity in commercially available enzyme panels (SAP-II and SAP-III) indicated qualitative differences among the eight strains ofBacillus sphaericus tested. These differences involved specific substrates utilized, the importance of sampling time, as well as differences between whole cells and cell-free extracts. Further detailed analysis of four of thel-amino acid-β-naphthylamide substrates using polyacrylamide gel electrophoresis (PAGE) demonstrated a series of allelic differences in the multilocus patterns observed. The resulting phenogram constructed from the enzyme and PAGE information showed a marked separation of the noninsecticidal strains from the insecticidal strains (58% similarity). In addition, there was a separation within the insecticidal strains of strain SSII-1, phage type 2 from strain 2297, phage type 4, and of both of these strains from the remaining highly insecticidal members of phage type 3 (strains 1593, 2013-4, 2362, 2500).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01569431
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